-
Články
- Časopisy
- Kurzy
- Témy
- Kongresy
- Videa
- Podcasty
Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
Authors: Adele Diamond aff001; Chris Lee aff001; Peter Senften aff001; Andrea Lam aff001; David Abbott aff001
Authors place of work: Program in Developmental Cognitive Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada aff001
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0222447Summary
The kindergarten program, Tools of the Mind (Tools), has been shown to improve executive functions (as assessed by laboratory measures) and academic performance. The objective here was to see if Tools can improve executive functions in the real world (in the classroom), academic outcomes not previously investigated, reduce bullying and peer ostracism, and increase teachers’ and students’ joy in being in the classroom. This first randomized controlled trial of Tools in Canada included 351 kindergarten children (mean age 5.2 years at entry; 51% female) in 18 public schools. Stratified randomization resulted in teachers and students in both groups being closely matched. Teachers in both groups received the same number of training hours and same funds for new materials. Outcome measures were pre and post standardized academic skill assessments and teacher online survey responses. This study replicated that Tools improves reading and shows for the first time that it improves writing (far exceeding levels the school districts had seen before), self-control and attention-regulation in the real world (e.g., time on task without supervision), reduces teacher burnout and children being ostracized or excluded, and increases the joy students and teachers experience in school. By Spring, Tools teachers were still enthusiastic about teaching; control teachers were exhausted. These results were not only better than the control group but also better than Tools teachers experienced the year before Tools. Thus, children in a kindergarten curriculum that emphasized play, improving self-regulation, working together and helping one another, and hands-on learning performed better academically, showed less bullying and peer ostracism and more kindness and helping behavior than students in more traditional classes, and teacher enthusiasm for teaching soared. Tools reduced initial disparities separating children, schools, and teachers.
Keywords:
Biology and life sciences – Neuroscience – Cognitive science – Cognitive psychology – Learning – Human learning – Learning and memory – Psychology – Social sciences – Sociology – People and places – Population groupings – Professions – teachers – Medicine and health sciences – Education – Schools – Age groups – children – Families – Psychological stress – Mental health and psychiatry – Language – Academic skills
Introduction
Self-control and attention-regulation in early childhood are highly predictive of school performance [1–4], workplace success [5, 6], health [6–8], and life satisfaction [9–11]. They are often more predictive than IQ [6, 12, 13] or socio-economic status (SES) [6, 14]. Children who enter school with poorer academic skills and poorer self-control and attention-regulation quickly fall behind and the gap progressively increases in school achievement [14, 15] and health [16, 17]. Hence there is great interest in helping children enter Grade 1 with the academic and executive function (EF) skills they need to launch them on a positive trajectory.
Similarly, social-emotional well-being in childhood predicts better school performance [18–21] and better outcomes on diverse variables in adults [19]. Student bullying and peer exclusion are major social and mental health concerns [22, 23] and classroom stress is causing teachers to burn-out and leave the profession in unprecedented numbers [24–26]. Hence there is great interest in improving students’ camaraderie and kindness, and reducing stress, in the classroom.
Much of the focus has been on prekindergarten programs [27–32]. Kindergarten represents a much less-studied context for investigating ways to improve social-emotional and EF competencies. Yet free, public kindergarten is available throughout most developed countries. At least one longitudinal study reports that attending a higher quality kindergarten is associated with higher rates of college attendance and higher earnings in adulthood [33].
This paper reports the results of a study that investigated whether the Tools of the Mind (Tools) kindergarten program could improve self-control and attention-regulation, academic performance, prosocial behavior, and reduce classroom stress and teacher burnout.
Reducing stress and increasing social harmony are not only important as factors that improve EFs and academic performance, but are important goals in their own right. A program that can reduce ostracism and bullying and reduce teacher burnout is one worth taking a look at. Such a program was examined here.
To unpack the terms used above a bit, self-control and attentional control comprise the “inhibitory control” component of EFs [34]. Self-control involves resisting temptations (including all the temptations not to stay on task or see it through to completion) and resisting speaking or acting reflexively (e.g., instead of responding immediately, giving oneself time to think or calm down before acting). Attentional control involves resisting distractions, being able to pay attention and stay focused for an extended period.
These inhibitory control abilities are critical for success in school [1–4] and in social relations [35–37]. They are needed for inhibiting all the pulls not to pay attention or stay focused and also for complying with school norms, such as staying seated or raising one’s hand, and social norms, such as not grabbing what someone else has or not talking while someone else is speaking. This is probably one of the many reasons why EFs, social-emotional competence, and academic performance are highly interrelated, e.g. [38–40].
The other EFs are working memory, cognitive flexibility, reasoning, and planning [34], but it is inhibitory control that is most predictive of long-term outcomes [6, 7]. A reasonable prediction is that a school program that improves inhibitory control, in addition to addressing academic skills, should produce better academic outcomes than programs that address academic skills but do not address inhibitory control or do so less successfully. We tested that prediction here.
If a person feels lonely or rejected, or is stressed or sad, that negatively impacts inhibitory control, academic performance, and physical and mental health (evidence that loneliness impairs EFs and specifically inhibitory control [41–43], academic performance [20, 44], and health [42, 45–47]; evidence that stress impairs EFs and specifically inhibitory control [48–50], academic performance [51–53], and health [54–56]; evidence that prolonged sadness impairs EFs and specifically inhibitory control [57–59], academic performance [60, 61], and health [62–65]. Therefore, a reasonable prediction is that in a school program that promotes students working together and being kind to and supporting one another (i.e., prosocial behavior [66]) one should find less peer rejection, more joy in the classroom, less teacher burnout, and better student academic performance and inhibitory control.
Tools is a kindergarten curriculum that focuses as much on improving EFs (especially inhibitory control), classroom climate, prosocial behavior and interpersonal skills as on improving academic skills. There is already evidence that it improves EFs, academic performance, and teacher-child relationships and reduces aggression [67–69], though when only parts of the program have been implemented as an add-on to the curriculum, those benefits have not been observed [70, 71].
Three independent evaluations of Tools have been published. The first, published in Science [69], found that recent graduates of Tools showed much better attention-regulation on a Flanker-type task (85% vs. 50% correct) than controls. Children were not evaluated before the intervention so it is possible that children in Tools had better attention-regulation at the outset, though the groups were closely matched on many demographic variables. At-risk, low-income children had been randomized to Tools or to another new curriculum that the school district had developed and predicted would outperform Tools. One school became so impressed by how much Tools children were out-performing others that they dropped out of the study and switched all kindergarten classes to Tools, feeling it unethical to deprive any of Tools.
A much larger study [67, 68] found better and more improved vocabulary, math, teacher-reported teacher-child relationships, and emotion-regulation on the dot-probe task. They did not find, however, better or more improved inhibitory control or cognitive flexibility on the Hearts and Flowers task, card sorting, or Flanker tasks in kindergarten children in Tools versus controls. They also found less and more reduced teacher-reported conduct problems or aggression in kindergarten children in Tools versus controls. Academic benefits were even larger the following year (Grade 1), where gains in reading first became evident. Effects were about eight times larger in low-income schools.
The third study [72] compared a daycare-based Tools program for children 3–4 years old to a high-quality, existing play-based program. Children in Tools whose parents rated them as highly hyperactive and/or inattentive in the Fall showed greater gains on an inhibitory control task of self-control than control children. The authors concluded that “Tools may be advantageous in classrooms with children experiencing greater challenges with self-regulation, at no apparent cost to those less challenged in this regard” (p. 2).
We predicted we would find benefits from Tools on important variables not previously investigated: (a) the academic skill of writing, (b) camaraderie and helping one another in the classroom, or its flip side reduced peer ostracism and exclusion, (c) teachers’ joy in teaching, (d) students’ joy in learning, and (e) EFs in the real-world versus on laboratory measures (specifically the ability to inhibit distraction in the classroom and stay on task), in addition to replicating previously demonstrated benefits to reading. We predicted that classrooms with less play, hands-on learning, or incorporation of training and scaffolding of EFs in school activities, even if they spent more time on academic content, would be less successful in improving academic outcomes and would be characterized by greater stress in the classroom and more teacher burnout.
Research design
The year before implementation, all public elementary schools in Vancouver and Surrey, the two largest school districts in British Columbia (BC), Canada, were queried to see if a kindergarten teacher at the school was interested in implementing Tools and if the principal was also supportive of that. All schools where both the principal and at least one kindergarten teacher responded ‘yes’ were included in the pool from which random selection was made. This was done because one would expect implementation of Tools to be poor where the teacher or principal did not want it, and the strong teachers’ union would not allow teachers to be told to implement a test curriculum they did not want.
Because teachers, principals, or schools open to implementing Tools might differ from those unwilling to go to the effort to learn and implement a new curriculum, we also selected the control schools from the same pool of schools. Within each city, pairs of closely-matched schools were created from this pool (matched on the relevant kindergarten teacher’s years of experience and training and on socio-economic characteristics of kindergarten children at the school including ethnicity, subsidized lunch status, and home language). Ten pairs were randomly selected and one member of each was randomly assigned to implement Tools.
This study had human subjects research ethics approval from the University of British Columbia, Vancouver School Board, and Surrey School Board. Informed written consent was obtained from all teachers for their participation and all principals for their school’s participation. The only data from children were their scores on BC assessment tools and their ESL and subsidized-lunch status, which the school districts collects as part of their educational mission, and which we received aggregated by classroom. Since we did not collect any data directly from the children we did not request consent from them or their parents.
One pair dropped out a couple of months into the school year. Both teachers had personal, family reasons for not being able to participate in the study. We thought it would be too difficult for a teacher new to Tools to catch up at that point, so did not replace that pair.
Control condition: Existing curriculum in BC kindergartens + special workshops
Kindergartens in BC are all full-day. Most kindergartens have 20–22 students. All follow the same prescribed learning outcomes and principles of appropriate practice [73]. Thus, the curriculum is the same in Vancouver and Surrey, and in Tools and control classes. The BC Ministry of Education is committed to educating children not just in academics but also in social responsibility. Most teachers (89% of control teachers and 77% of Tools teachers) had received training in the Second Step® social-emotional learning (SEL) program that teaches social skills, empathy, and emotion management [74]. Additionally, 56% of control teachers and 50% of Tools teachers had received training in the MindUp™ program (which teaches social and emotional skills and mindful awareness) [75].
There was play in control classes, but it was usually unsupervised or scripted, not as in Tools. (For example, a child in Tools might record a plan to play an astronaut today. Early in the year, he might abandon that after 1–2 minutes to play something else. In control classes that would be fine. In Tools, the teacher comes over with the child’s plan, “You need to follow through with your plan. You can be something else tomorrow.” Children in control kindergartens do not tend to make plans. By the Spring, Tools children sustain make-believe dramatic play for 25–30 min without adult guidance; control children tend to do so for only a few minutes).
Control kindergartens had more ‘whole group’ activities. In Tools kindergartens, children worked more independently in pairs or small groups. Control kindergartens used rewards (e.g., gold stars); Tools does not. Time-outs are used in control classes, but not in Tools.
Experimental condition: Tools of the Mind
The Tools curriculum, which exists only for preschool and kindergarten, is grounded in the idea that social-emotional development and improving EFs, especially inhibitory control, is as important as teaching academic skills and content. Developed by educational psychologists, Bodrova and Leong [76], Tools is based on the work of Vygotsky [77, 78] and has been revised and improved over 23 years of iterative research and implementation.
Vygotsky emphasized that cognitive and social development are fundamentally intertwined and that social interactions are key to developing EFs and cognitive skills, thus in Tools there are not separate activities for academics and SEL, rather activities address both. That makes Tools rather unique. Tools teachers are taught how to foster paired activities and an atmosphere of cooperation and mutual support. A major difference between Tools and traditional kindergarten is the far greater use of peer social interaction for learning in Tools–two children helping one another, cooperating in learning the material together or in one teaching or checking the other. Children learn to help bootstrap one another’s EFs, providing helpful reminders to each other. Consistent with Vygotsky’s view that language is central to EF development, Tools provides specially designed opportunities for children to talk to each other, thus aiding the development of oral language as a tool for social interaction and encouraging the emergence of private or “inner” speech that serves as a mechanism for self-regulation [79, 80].
Vygotsky also emphasized the importance of social pretend play (e.g., playing doctor and patient or grocery store) for the development of EFs in young children. It is an important component of Tools. The quantity and quality of social pretend play in Tools distinguishes it sharply from traditional kindergarten. Children enact roles with implicit rules, role speech, and the use of symbolic props (e.g., a block might be a phone or a loaf of bread). Mature make-believe play challenges and helps build all three core EFs: Children must inhibit acting out of character (inhibitory control), hold in mind the role they’ve chosen and those of others (working memory), and flexibly adjust as their friends take the scenario in unexpected directions (cognitive flexibility).
Each child is paired with every other at least once every week in Tools. Students adapt to the personal quirks of their classmates. They know if they are not paired with their favorite person it won’t last long, everyone will also be paired with this person, and soon they will be paired with someone else, so complaining about being “stuck” with someone (so common in the early grades) is absent.
Another marked difference between Tools and traditional kindergarten is the far greater time children spend in hands-on learning and far less time in teacher-led whole-group activities in Tools. As one teacher put it, with Tools she is the “Guide on the Side” rather than the “Sage on the Stage.” At any age we learn something better when we need it for what we are doing [81, 82]. For young children that is particularly important because they have such difficulty sitting and listening for any length of time.
Because children can work on their own or with one or two others, teachers can provide individualized instruction and assessment. A Tools teacher helping one child is not taking time away from others because others are engaged in meaningful activity. Because children can work on their own they can proceed at their own pace, without rushing other children or holding them back. The use of self-correcting materials enables children (or their “study buddy”) to detect and correct errors without the teacher having to tell them.
Rather just assessing a child’s current level of competence (as do standard assessments), Tools teachers use dynamic assessment to determine a child’s readiness to advance or why the child is having difficulty grasping something. This consists of a series of prompts and hints to probe children’s skills and understandings that are “on the edge of emerging [78].”
Weekly one-on-one Learning Conferences with the Tools teacher engage the child in planning his/her own education, empowering the child to take a lead role. Children “talk through” both correct and incorrect answers, helping them learn to reflect on and correct mistakes. In these conferences errors are treated as valuable learning opportunities, not anything to be embarrassed about.
A distinguishing feature of Tools is the absence of extrinsic incentives, such as stickers or gold stars. The Tools’ philosophy is that learning and developing mastery are intrinsically rewarding, and that external rewards would convey the wrong message.
An example of paired peer-social interaction in learning activities as well as how training EFs is seamlessly incorporated to Tools academic activities is the Tools literacy activity called “Buddy Reading.” Children pair up to take turns “reading” their picture book to one another. With each child eager to tell his or her story; no one wants to listen. To help the children succeed at exercising inhibitory control, the teacher provides scaffolds (one child per pair gets a line drawing of lips and the other a drawing of an ear); the teacher explains that “ears don’t talk; they listen.” This enables the child with the ear to inhibit talking and to listen. Children then trade drawings and roles, thus learning to enact the social norms of taking turns and waiting one’s turn. After a few months, the pictures are no longer needed; children can succeed without them.
This illustrates another key aspect of Tools: Rather than letting children flounder, teachers provide supports (scaffolds) so that most children, regardless of ability level, succeed. Concrete visual signs and symbols help bootstrap fragile working memory and language skills. Classroom materials have few distractions, thus making attention regulation easier. These supports are gradually removed as children improve. Thus children succeed, instead of experiencing failure or criticism. The boost to self-confidence and self-esteem from experiencing success is one key element of Tools. Indeed, testers in one study of Tools [69] could tell which children had been in Tools because on the most difficult conditions control children gave up but Tools children insisted, “I know I can do this. Let me try again.”
Because scaffolds and other children help students inhibit their impulsive behaviors and act appropriately, Tools teachers have less worries about students misbehaving; they can relax. Having fewer worries about being reprimanded, the children can relax.
For those wanting more information, S1 File provides a brochure about Tools.
Comparability
We went to lengths to treat both Tools and control teachers comparably. Tools teachers received a three-day workshop on Tools before the school year began. We offered control teachers three days of workshops at the same time on whatever they wanted. They made suggestions and voted on them. Their workshops received excellent reviews from the teachers. (They chose one-day workshops on “Using Technology in your Kindergarten Classroom,” “Teaching Children with Autism Spectrum Disorder,” and “NOT your typical approach to Math in Kindergarten.”) Both groups of teachers were comparably compensated for their time in attending the three days of workshops. The four one-day workshops for Tools teachers during the school year were held on Professional Development Days when school districts arranged for instruction and enrichment programs for teachers.
Kindergarten classes in the US usually have a teaching assistant besides the teacher; kindergartens in BC do not. Tools needs such an assistant for the 90-minute literacy block each morning. Therefore, we paid a token $30/day for kindergartens in both groups to have an assistant for 90 minutes daily. Typically the assistant was a relative of one of the children in the class or a friend or relative of the teacher. Teachers in the Tools group needed to purchase supplies. Therefore, all teachers in both groups received an allowance of $1,000 to purchase supplies for their classroom. All funds for this came from the BC Ministry of Health and BC Mental Health Foundation.
There was one unintended difference between the Tools and control groups: Tools teachers chose on their own to meet together a few times during the school year (besides when there was a workshop)—thus providing social support and enabling each to learn from one another. This probably helped less-experienced teachers to do so well with Tools. (Had we known about these meetings, we would have arranged for similar meetings for control-group teachers).
Assessments
Pre-intervention levels of the children on language and math skills and on behavioral control and sociability were determined within the first month of school. Post-intervention levels were determined eight months later (May 5–15). Academic skills were assessed using BC’s objective, standardized assessment tools [83] including the Developmental Reading Assessment (DRA2)™ [84] (see S2 File). These results were also obtained for the pre-Tools year for the classes taught by teachers assigned to Tools. Reading and writing were done in English. Students’ attitudes and behavior were reported by teachers. Teachers responded to an online survey (using the Survey Monkey platform) with multiple-choice questions and open-ended opportunities to elaborate. The survey questions are provided in S3 File.
Data analyses
Since randomization was at the level of schools, analyses of student outcomes were nested within schools. Since the data were often ordinal, binary, or not normally distributed, in most cases the generalized estimating equation was used for data analyses, as it provides valid inferences regardless of the data distribution and is robust for both parametric and non-parametric analyses. Chi-squares were generated from the generalized estimating equation within a poisson loglinear model when the data distribution was skewed, or, for categorical data, a binary logistic model. For interval data, where the data were roughly normally distributed and the variances roughly equal between groups or could be made so by a transformation such as arcsine, analysis of variance (ANOVA) was used to compare one group to other. Linear regression was used for the analysis of whether Tools helped the children more behind in reading more than those who started out reading at a higher level.
S4 File presents the results for all of our statistical analyses controlling one at a time for free-lunch status, ESL status, and years of teaching experience. With nine classrooms per condition, we do not have the power to control for more than one covariate at a time. Free-lunch status was occasionally related to our outcome measures, as was ESL status, years of teaching rarely. All analyses are reported in this paper controlling for free-lunch status (as a proxy for lower SES). To see the results controlling for ESL status or years of teaching please refer to S4 File.
Since the dependent measures are interdependent and interrelated, one could argue that correcting for multiple comparisons is not needed. On the other hand, with several dependent variables we felt some correction should be applied. As a compromise between those two viewpoints, we have divided the normal significance level in half and required p < 0.025 for a result to be considered statistically significant. To help illuminate the reasons behind why statistical differences were found and to put a human face on them, direct quotations from teachers’ survey responses are included in S5 File.
Results
Descriptive statistics
Teachers and students were well matched in the two groups. See Table 1. Most teachers in both groups were outstanding and very experienced. There were nine teachers (schools) per group; 172 children in the Tools group; 180 children in the control group.
Tab. 1. Descriptive statistics.
Reading
At the beginning of kindergarten, most children could not read even the simplest words. Most classes had no child who could read more than the simplest sentences; the exceptions were one Tools class and three control classes which each had three children who could read at a higher level. No significant difference in reading skills was found between Tools and control classes in September.
By May, eight of the nine Tools classes had more than two children reading at Grade 1 level or higher, while only one of the nine control classes had more than two children reading at Grade 1 level or higher. Children in Tools made significantly greater progress in reading than children in the control group (χ2(1, N = 18) = 4.64, p = 0.02, odds ratio = 3.25). Three times more children were reading at Grade 1 level or higher by May in Tools classes than in control classes (33% vs. 10%): F(1,15) = 6.67, p < 0.02, partial eta squared (ηp2) = 0.33. See Fig 1. Conversely, almost three times more children were still non-readers by May in control classes than in Tools classes (28% vs. 10%): F(1,15) = 6.02, p = 0.02, ηp2 = 0.29.
Fig. 1. Reading skills.
By May, three times as many children in Tools than in control classes were reading at Grade 1 level or better, although both groups started out comparably in the Fall.
This better progress in reading with Tools was also reflected in comments by teachers and parents (see S5 File–Comments by Teachers, Parents, and Principals). Most Tools teachers said they had never seen progress like this in reading before.: “The literacy level in the classroom this year is much higher [than in past years].”
Lower-income children in Tools (those receiving subsidized lunch at school) did not show greater progress in reading than did children in Tools from more prosperous homes (χ2(1, N = 9) = 4.17, p = 0.12 [NS], odds ratio = 2.05; here the covariate was ESL status instead of subsidized lunch). With only nine Tools classes, though, there was limited power to detect a difference. The reading of those who started farther behind in September, however, showed far more progress than the reading of those who started out reading at a more advanced level, as the regression of the difference in reading level (May minus September) against reading level in September shows: F(2,6) = 18.18, p < 0.005, R2 = 0.89.
Writing
Children in the two groups started out similarly in writing ability (χ2(1, N = 18) = 1.45, p > 0.20 [NS], odds ratio = 1.10). In September, roughly three children per class in both groups (range = 1–5) could do no better than scribble. In 67% of Tools classes and 56% of control classes, most children could write their first name without copying (85% of children in Tools and 87% of control children). By May, almost all children in both groups could do better than that. The difference was in how far they had progressed. Children in Tools progressed much farther (χ2(1, N = 18) = 20.20, p < 0.001, odds ratio = 26.18). Three times as many children in Tools versus control classes reached as far as being able to write a full sentence they themselves composed with most sounds represented (30% vs. 10%). Almost three times as many children in Tools versus control classes progressed further than that; they could write 2 or more consecutive sentences they composed with most sounds represented (33% vs. 12%). More children in Tools than in control classes progressed from September to May to being able to write a full sentence or multiple consecutive ones that themselves composed with most sounds represented: F(1,15) = 18.10, p < 0.005, ηp2 = 0.55. See Fig 2.
Fig. 2. Writing skills.
By May, three times more children in Tools than in control classes were able to write a full sentence they themselves composed or multiple consecutive ones (F[1,15] = 18.10, p < 0.001, ηp2 = 0.55).
It is not so surprising that the writing of children in Tools advanced further than the writing of control children since Tools emphasized writing and control classes did not, though the advanced level of writing by children in Tools would astonish most kindergarten teachers. Indeed, we had to add questions about children’s writing skills to the online teacher survey because the writing levels achieved by children in Tools exceeded the upper limits on the BC assessment tools for kindergarten. Teachers reported never having seen writing progress like this before (see S5 File) and the data bear them out (see Fig 3).
Fig. 3. Percentage of children able to write at least one sentence they composed, comparing outcomes for children taught by the teachers assigned to Tools in the pre-Tools year (before Tools was implemented) and Year 1 of Tools.
Children taught by the same teachers the year before those teachers implemented Tools were significantly less advanced in writing than children taught by those teachers the next year when they were implementing Tools: χ2(1, N = 8) = 13.54, p < 0.01, odds ratio = 9.42).
Math
Both groups started out with virtually no math skills. Because of the complexity of implementing Tools for the first time in Canadian kindergartens, and because of a decision to concentrate on language skills, math was not a focus of the Tools program in Year 1 of its implementation in BC. Thus, the developers of Tools and local Tools coaches did not expect Tools children to advance more in math than did controls, but they came close to doing so: In eight of the nine Tools class, most children progressed to being able to do simple addition and in four of the nine most progressed even farther to simple subtraction. In no control class were most children able to do simple subtraction. At the lower end of continuum, in only two Tools class were most children able to do no better than to count up to 20 objects, while that was true for four of the nine control classes. Neither the difference between Tools and control classes in the percentage of children who could do no better than count up to 20 objects in May nor the difference in the percentage who could do simple subtraction by May reached significance however (F(1,15) = 3.16, NS; F[1,15] = 1.17, NS; F[1,15] = 1.77, NS, respectively).
Social inclusion and other prosocial behavior
Both groups started off comparably. Tools teachers reported that in the Fall they had 3–8 children who had difficulty interacting in the classroom (mean (SD) = 5 (0.7) per class; 26%). Control teachers reported that they had 0–9 children who had difficulty interacting in the classroom (mean (SD) = 4 (2.5) per class; 20%). By May, the percentage of children reported to be having problems interacting was lower in Tools than in control classes (F[1,15] = 6.83, p < 0.02, ηp2 = 0.31) and it had gone down much more in Tools than in control classes (F[1,15] = 20.59, p < 0.001, ηp2 = 0.58).
Tools teachers commented, for example: “In years past, they have not helped each other to this degree. This year I have witnessed many students going to another student’s aid.” “They offer help and assistance when needed without being asked and without belittling the struggling student. They look out for one another and ensure everyone has someone to play with or talk to.” “They are cheering each other’s success, are more supportive of each other.” “More of a sense of community [this year]. I see children helping each other and looking after each other to a greater degree from in the classroom to out on the playground at recess [than in past years].” See more comments on this topic in S5 File.
On the other hand, control teachers commented, for example: “[We] have a few children who have a very difficult time acting kind most of the time. This makes it difficult to have a totally close knit community, as these children, while they have progressed, still need significant support to make choices that benefit everyone and not just themselves.” “The students are learning to read and write, but their ability to be well-adjusted and considerate human beings lags behind.” More comments by control teachers are provided in S5 File.
Only 22% of Tools teachers reported the presence of cliques in their classes compared with 89% of control teachers. The difference in the incidence of teacher-reported cliques was significant: χ2(1, N = 18) = 11.99, p < 0.001, odds ratio = 15.77). Fully 89% of control teachers reported in May that there was at least one child in their class who tended to be ostracized or left out; only 33% of Tools teachers reported that. Instances of a student being left out or ostracized were noticeably more common in control versus Tools classrooms: (χ2(1, N = 18) = 4.87, p = 0.02, odds ratio = 3.45). Teachers’ comments echo the stark difference evident in Fig 4 (see S5 File).
Fig. 4. Teacher reports of peer rejection and presence of cliques about here.
In-groups and out-groups and peer rejection or exclusion were the norm in control classes and rare in Tools classes.
Attention-regulation and self-control
Ability to get back to work after a break
Back in the Fall, most teachers in both groups (89% in each) felt their students were not good at getting back to work after a break. Though comparable in the Fall, the groups differed by the Spring. All Tools teachers reported their students were good at getting back to work after recess and weekends; only 56% of control teachers reported that (χ2(1, N = 18) = 5.31, p < 0.02, odds ratio = 5.28; see Fig 5). Many Tools teachers mentioned how different this was from past years, e.g., “In 20 years I have never been able to come back from school holidays so seamlessly.” This difference already emerged by Spring break (χ2(1, N = 18) = 4.92, p = 0.02, odds ratio = 3.50). Eighty-nine percent of Tools teachers agreed strongly that their children had been good at getting back to work after Spring break; no control teacher strongly endorsed that. Indeed, 56% of control teachers disagreed, saying that their children had not been good at getting back to work after Spring break; only one Tools teacher disagreed.
Fig. 5. Teachers’ perceptions of students’ ability to get back to work after a break.
In the Fall, few teachers thought their students were good at getting back to work after a break. By the Spring, Tools teachers were almost twice as likely as control teachers to think their children now were good at getting back to work after a break.
Ability to work independently, without supervision
In the Fall, 55% of teachers in both groups said that children in their class were not capable of working on their own at all without supervision, even for a minute. The percentage of teachers endorsing that their children could work on their own for just 1–2 minutes without supervision was 44% for Tools and 33% for control teachers. Only one teacher said her students could work on their own for 3–5 minutes without supervision; that teacher was in the control group. By May, teachers in Tools said their children could be left to work without supervision for far longer than control teachers: F(1,15) = 11.43, p < 0.005, ηp2 = 0.43. See Table 2 and Fig 6.
Tab. 2. Fig. 6. Ability of children to work on their own, unsupervised.
By May, teachers in Tools felt their children could be left to work without supervision for far longer than did control teachers, although teachers’ estimates of this had been comparable in the Fall.
In their comments, teachers elaborated at length about this, and how different the experience this year in Tools classes was from previous years. See comments about this by Tools and control teachers in S5 File.
Tools teachers further commented on what the children’s better EF abilities to stay on task and control their attention and behavior has meant for what they can do in class: “The ability of my students to regulate their behaviour and to help those who still require some assistance has allowed me to be able to work with small groups as well as individually with specific students who require additional assistance. I have never been able to effectively do this ever with kindergarten students before.” “They are very self-regulated so I am able to work with a small group without being distracted. This is a wonderful gift.” “I have the freedom to work with small groups and help children learn at their own level; it helps provide students help where they need it and move them further faster. It is definitely more individualized…. Students easily work in small groups and can self-regulate while I work with students who need support.”
Teachers’ feelings about teaching
We asked teachers to rate how they were feeling in May on a scale of 1 (excited about teaching, energized) to 10 (exhausted, burned out, weary) and to rate how they felt looking ahead to the next school year from 1 (excited about starting again, totally enthused) to 10 (not looking forward to it, looking forward to retirement). To both questions, over three-quarters of Tools teachers chose #1 or #2; no control teacher did. They were exhausted. See Fig 7.
Fig. 7. Teachers’ feelings about Teaching.
Over three-quarters of Tools teachers, but none of the control teachers, responded in May that they were extremely excited about teaching (choices 1 or 2 on the 10-point scale): χ2(1, N = 18) = 4.99, p = 0.02, odds ratio = 3.58. Similarly, all Tools teachers responded that they were utterly enthused and looking forward to the next school year (choices 1 or 2 on the 10-point scale), while only 2 control teachers selected choice 2: χ2(1, N = 18) = 5.67, p < 0.02, odds ratio = 5.86.
Comments by Tools teachers indicated that students’ joy in coming to school, excitement about learning, and marked progress were the main contributors to their own excitement about teaching: “I have seen so much success in my students’ learning that I can’t wait to begin teaching again next year now that I have a better understanding of the program and all of its benefits!” “I have enjoyed seeing the students get so excited about coming to school and learning….[M]any students refused to miss school even if they were sick.” “What I have enjoyed most about my class this year is… The smiles and joy.” “What I liked most about teaching this year: Students’ enthusiasm towards learning and their pride in their development.” More comments by teachers are provided in S5 File.
Change in teachers’ expectations of what kindergarten children are capable of
Tools teachers also expressed how their expectations for what the children could accomplish had changed, as had those of the parents: “Children in kindergarten are capable of so much more than I imagined.” “Parents are astonished with what their children can do.” “New kindergarten parents are pleased; parents who have had another child in kindergarten are amazed this year with what their children can do.”
Discussion
This study found that Tools not only improves academic outcomes in reading and writing, but also shows for the first time that Tools also improves EFs in the classroom (being able to stay on task and quickly resume work after a break), markedly reduces teacher burnout and children being ostracized or excluded, and increases the joy students and teachers experience in school.
Limitations of the present study are: (1) Any new program may show benefits simply because it is new. Tools was new here and it was not compared to another new program but to a wait-list control group. (2) Teacher reports should be viewed cautiously because people can see what they hope and expect to see. (3) In the glow of the first year of a program, larger benefits are often seen than in subsequent years. (4) We might have had statistical power to detect group differences in math improvement or differential benefit from Tools in children from lower-income homes had we had more than nine classes per condition. (5) Though we had worked quite hard to match the Tools and non-Tools classes on teacher and student variables, hours of professional development, funds for materials, etc., one difference crept in unbeknownst to us: The Tools teachers arranged to meet together bi-monthly. It is possible that if the teachers in the control group had also met together, their results might have been better and the difference between their results and those from Tools less marked.
Even taking those considerations into account and therefore assuming that gains may appear larger here than they truly are, even if the true gains are half of what was observed, they are still quite impressive whether one looks at objective measures of academic performance, first-person reports of reduced teacher burnout, or teacher reports of student behavior. Results were better for Tools classes across most domains (reading, writing, peer inclusion, children’s ability to get along with, and be kind and helpful to, one another, children’s ability to work independently and stay on task without supervision, their ability to settle down quickly after a break and get back to work, teachers’ renewed joy in teaching, and students’ excitement about learning and joy in coming to school). The one exception was math, where results tended to be better for Tools classes, but not significantly so. The results were better than (a) the same teachers had in previous years and (b) control-group teachers had in the year of the study.
The percentage of children able to write one or more self-composed sentences was almost 300% greater in Tools classes (63% in Tools versus 22% in control classes), though writing skills had been comparable in Tools and control classes in the Fall. Conversely, the percentage of children whose writing skills were no better than the initial sounds of words was almost 300% greater in control classes (8% in Tools versus 23% in control classes). Tools emphasized writing and control classes did not. Thus, it is not surprising that children in Tools showed more advanced writing than control children. The extent to which children in Tools progressed is quite surprising, however—well beyond what anyone in BC public schools had seen previously in kindergarten children and well beyond the upper limits on the BC assessment tool for kindergarten. These results suggest that if writing is encouraged and supported in the way that Tools does, kindergarten children are capable of far more advanced writing than most educators and parents have assumed (and children start kindergarten 6 months younger in BC than in general in the US). (Tools teaches writing before reading, and being able to write is critical for recording what they plan to do in their play scenarios so children in Tools are highly motivated to master that. See S6 File for writing samples).
The developers of Tools had prioritized aligning Tools with Canadian learning standards and styles (this being the first implementation of Tools in any Canadian kindergartens) and had prioritized language skills over math skills for the first year of implementation. Thus, outcomes for language skills were markedly better for Tools versus control children and outcomes for math only marginally better. Importantly, math did not suffer in the Tools classes. There was no tradeoff with language skills being better in Tools classes and math skills worse. Math performance was at least as good, indeed marginally better, among children in Tools versus control classes.
By the end of kindergarten, Tools teachers estimated that their children could continue to work unsupervised for two and a half times longer than control teachers estimated for their students (12.3 versus 5.1 minutes). After breaks, 100% of children in Tools, but only about 50% of control children, could get back to work right away, according to teacher reports. This was echoed in marked differences between Tools and control classes in teachers’ comments about children’s self-regulation, ability to pay attention, and ability to work independently. This speaks to one of the greatest challenges voiced by Grade 1 teachers and one of their most common complaints—children’s poor self-regulation and ability to pay attention. Indeed, teachers report that the task of managing the classroom can lead to high levels of stress and burnout [85]. Children’s ability to pay attention when they enter Grade 1 predicts their later achievement in both math and reading [86, 87]. Children’s ability to work independently is critical to teachers’ ability to give individual attention to a student and for students to be able to work at different levels or follow their unique interests. Indeed, teachers mentioned that before Tools they had had difficulty supporting the more advanced students to move ahead of the rest.
In all control classes but one, teachers reported at least one child was likely to be left out by other children and in-group cliques had formed. In contrast, in all but two or three Tools classes, that was completely absent. Many control-group teachers mentioned in May that were still problems with some children hitting others or refusing to share, but that was no longer present in Tools classes. These findings have implications, we think, for reducing the incidence of bullying and of mental health issues in primary school.
Those large differences are particularly noteworthy because BC emphasizes educating children to be socially responsible citizens who are kind and compassionate. All teachers had this as a goal, but Tools enabled teachers to experience more success in realizing that goal, even though most teachers had received training in the Second Step social-emotional learning program and about half had received training in the MindUp mindfulness and social responsibility program. One would expect differences to be even greater between these Tools classes and classes where prosocial behavior was not a curricular priority.
Control group teachers were wait-list controls. They were looking forward to also being trained on Tools. In the meantime, during the study year, they were given the opportunity to get professional development workshops for free on whatever they wanted. They were thrilled with the three workshops they chose and much appreciated the funds we provided for new materials. There was no indication they were demoralized at not being chosen to be trained on Tools at the outset of this study.
By May, however, all teachers in the control group were indeed exhausted. None felt excited or energized about teaching or excited and enthused in looking ahead to teaching next year. In contrast, almost 80% of Tools teachers did (78% versus 0%). In part that was because the Tools teachers perceived their students as experiencing so much joy in school, progressing so far, and gaining so much confidence and sense of self-efficacy. Indeed, Tools teachers reported seeing improvements in all three core needs identified in self-determination theory [88] (increased feelings of social relatedness [community], autonomy, and perceived competence).
Economically-disadvantaged children benefited (as past studies had demonstrated, e.g. [68, 69]), but for the first time Tools was also tried in schools serving primarily middle and upper-middle income families. Children across the board benefitted from Tools–whether higher or lower socio-economic status (SES) and whether more advanced in academic skills or self-regulation at school entry or not. Outcomes did not differ significantly by teacher characteristics or children’s free-lunch or ESL status.
Children in Tools with weaker reading skills at school entry made greater progress in reading than other children in Tools. (Also, while the results for reading had differed across Tools classes with more versus fewer lower-income children in the Fall (F[1,6] = 5.74, p = 0.03, ηp2 = 0.24), those differences largely disappeared by the Spring (F[1,6] = 1.08, NS). Tools, thus, tended to reduce initial disparities separating children, schools, and teachers. Regardless of the SES levels of students in the class, the prevalence of English-language learners, or the experience level of the teacher, by May over half the children in Tools were able to read and write independently. Principals and resource teachers were surprised, when they walked into Tools classrooms in the Spring, to be unable to identify the special needs students.
Our assessment measures did not show greater writing gains for Tools children from lower-SES homes than from more economically-advantaged homes (χ2[1, N = 9] = 3.37, NS). Yet, when the 2 Tools expert trainers from Colorado came for their Spring workshop and were given de-identified samples of the children’s writing, to their surprise they were no better than chance at identifying those from low-income classes and those from middle-income ones, whereas in the Fall the differences had been stark. This suggests that while our measures did not indicate differential progress, the gap appears to have closed at least to some extent. Differences by SES were still present to be sure, but they were noticeably reduced (so much so that no significant differences remained).
Null results for Tools versus comparison conditions were reported at a Society for Research on Educational Effectiveness (SREE) conference [89, 90] although these have never been published in a peer-reviewed journal. At the SREE meeting, Lonigan [89] reported no differential benefit to EFs comparing preschool Tools to his program (Literary Express™). EFs were not assessed in that study, however, so the report of no difference in EFs outcomes is curious. Many of the schools in that study requested that their district adopt Tools; no school requested that for Literacy Express.
Wilson and Farran [90] reported null results from Year 1 of their study of pre-kindergarten Tools in Tennessee and North Carolina. Theirs was a textbook-perfect research design, but some of their outcome measures were prone to ceiling and floor effects (e.g., most 5-year-olds pass the Dimensional Change Card Sort test). One school district in the Wilson-Farran study was so impressed by the markedly better writing of Tools children that the district used its own funding to have all its teachers trained in Tools. (Assessment of writing had not been part of the research study). Other school districts that had been in the study did likewise because principals and kindergarten teachers felt they observed better social skills and readiness for learning in children who had attended Tools pre-kindergartens versus children from other pre-kindergartens. (The research study had not evaluated children in kindergarten, but only at the beginning and end of pre-kindergarten).
A limitation of the present study was the lack of funding to follow the children into Grade 1 and beyond, and also to include additional cohorts in teachers’ second and third years of implementing Tools, as had been our plan. We had hoped to investigate whether similar results would be replicated with other cohorts and to investigate how long gains would last and whether they might even increase. There is much evidence of academic gains increasing over time from Tools and from other beneficial programs (e.g. [68, 91–94]).
One reason particularly large effects may have been found in the present study is that all teachers in both the Tools and control group had indicated a willingness to learn and implement Tools. Other studies may have assigned teachers to Tools who might have been disinclined to implement it, weakening their effects. Usually teacher preferences are ignored in implementation studies. But teacher preferences can exert large effects! A teacher who is opposed to a program is less likely to do a good job implementing it [95–97]. After a study documents benefits from that program, that same teacher might then willingly implement it.
There are limitations on the possible applicability of the results found here to other contexts: (1) Important differences between early education in BC and the US led the developers of Tools to feel that the implementation of Tools in BC was more developmentally appropriate and a truer implementation of the Tools philosophy than Tools in the US. Without having to worry about high-stakes standardized tests at the end of year, stress levels were lower and Tools could be implemented the way it was intended–following each child’s lead. A particularly important difference to the developers of Tools was the stronger emphasis on play in BC Tools classrooms than in US Tools classrooms. In BC, children had an hour of play daily where they dramatized what they had been reading. They became deeply immersed in it, becoming the characters, and wrote about what they had learned about the lives of the people. Almost all children attained the level of intentional, mature make-believe play that Vygotskians associate with the development of self-regulation. In the US, because of the press for academics, children have only 20–30 minutes, and less as the year progresses, to dramatize stories and they do so only once a week instead of daily.
Clearly a full hour of dramatic make-believe play daily plus time each day for other types of play is not inconsistent with children doing extremely well in kindergarten, since the children in the present study did extremely well. Indeed, it is possible that copious playtime in kindergarten may be critical for laying the groundwork for academic success. This is especially noteworthy since there is enormous pressure on teachers to allow less and less time for play and devote more and more time to direct academic instruction, even in kindergarten [98, 99].
(2) Another limitation on possible generalizability is that most teachers in the present study were experienced. Tools is a demanding curriculum. Teachers in the present study bemoaned the amount of information to learn, e.g.: “The vast amount of materials that accompany the program is a challenge.” “The most challenging thing was implementing everything in the program. Adding a few new things was okay but having to learn everything and teach all new things at once was very challenging.” Tools may work best with teachers with at least a bachelor’s education, as most teachers here had.
This study does not enable one to determine “the active ingredient” of Tools nor which benefits of Tools contribute to making other benefits possible. Our hypothesis is that Tools works because of the gestalt that is Tools and that searching for the key element would be futile and fruitless. We hypothesize that Tools improves EFs because it directly trains, scaffolds, and challenges them, providing numerous opportunities to practice exercising them at progressively more advanced levels, and because it supports them by improving emotional and social well-being. We also hypothesize that Tools improves academic skills by directly targeting them in ingenious ways and because Tools improves EFs and emotional and social well-being.
Most elements of Tools probably affect more than one outcome. For example, scaffolding EF skills not only helps children practice those skills at a more advanced level than they would otherwise be able, thus aiding the development of those skills, but also reduces stress in the classroom. Teachers are less worried about the children not being able to exercise self-control or attention-regulation and children are less worried about being scolded for not exercising those EF skills [76, 100]. Conversely, stress impairs self-control [101, 102] and attention-regulation [50, 103], and reducing stress aids them. Also, by scaffolds increasing the likelihood of success and reducing the incidence of failure, they help build children’s self-confidence and belief in their ability to succeed [76].
Once children have a modicum of self-control and attention-regulation, that makes possible being able to work alone or with another child without the teacher needing to control the class from the front of the room. That makes possible a host of beneficial educational practices such as individualized pacing, instruction, and assessment because all the children doing the same activity together is no longer required [76, 100].
The paired play (pairing each child with every other at least once every week) not only helps each child get to know all the other children better and learn to get along with and work together with each (helping to build a sense of community), but also aids the development of language and EFs through the regulation of one another by verbal correction and feedback [80]. In Tools, each child in a pair gets to play the role of the “checker” and the one being checked, including younger children serving as the checker for older ones. The hands-on learning by working together with another child aids mastery of the academic material [76]. The improved sense of camaraderie in the classroom, which paired play facilitates, probably also aids EFs.
The clearest findings in the present study are: (a) Tools reinvigorated teachers’ enthusiasm for teaching. Those concerned with teacher burnout should take note. Burnout is leading many teachers to leave the profession [25, 104] and it causes many who stay to have less commitment to their job and less patience with the children [24, 104, 105]. Job burnout also contributes to poor health [106, 107]. Indeed, a one-unit increase in burnout score was found to be associated with greater risk for hospital admission for mental health problems and for cardiovascular problems [107]. (b) Teachers perceived Tools as making a big difference and perceived far better outcomes on an array of dimensions (academics; kindness, cooperation, and helping; joy in learning) than in the past. This seems to be a consistent theme across all studies of Tools, even where null findings have been reported. It is unlikely that that these findings are simply a halo effect for a new curriculum, because when compared head-to-head with another new curriculum, Literacy Express, in the study mentioned by Lonigan (89) many teachers requested that the district adopt Tools but none requested that for Literacy Express. It may be that teachers are seeing what they want or expect to see, but in the case of Diamond et al. [69] the teachers expected the district’s new program to yield better results than Tools and the district administration was very dismayed when it did not, since they had put so much effort into developing their new curriculum and were so proud of it. As researchers we need the humility to accept the possibility that teachers are picking up on things our assessment tools might be missing.
(c) Tools markedly improved reading and writing and these findings provide an existence proof that kindergarten children can write at more advanced levels than most had thought–composing sentences of their own creation with advanced vocabulary (e.g., stalagmites and stalactites). Tools teachers in the study said that their experience this year had changed their expectations of what kindergarten children could accomplish, e.g., “Children in kindergarten are capable of so much more than I imagined.” This occurred despite–or perhaps because of–carving out an hour a day for social dramatic play, encouraging other forms of play, and spending as much time on social-emotional growth as on academic growth. Clearly there is no indication whatsoever that play or social emotional learning interfered in any way with academic progress, and might well have aided it.
The findings of the study have relevance to several issues of keen scientific and societal interest: reducing the epidemics of bullying and teacher burnout, increasing student engagement in school, improving academic outcomes, and reducing socioeconomic inequalities in academic performance and EFs.
Supporting information
S1 File [pdf]
Brochure.S2 File [pdf]
BC’s kindergarten assessment tools.S3 File [pdf]
Survey monkey teacher questions.S4 File [docx]
Table 3.S5 File [pdf]
Comments by teachers, parents, and principals.S6 File [pdf]
Two writing samples.
Zdroje
1. Allan NP, Hume LE, Allan DM, Farrington AL, Lonigan CJ. Relations between inhibitory control and the development of academic skills in preschool and kindergarten: A meta-analysis. Dev Psychol. 2014;50 : 2368–79. doi: 10.1037/a0037493 25069051
2. Gilmore C, Attridge N, Clayton S, Cragg L, Johnson S, Marlow N, et al. Individual differences in inhibitory control, not non-verbal number acuity, correlate with mathematics achievement. PLoS One. 2013;8: e67374. doi: 10.1371/journal.pone.0067374 23785521
3. Lubin A, Vidal J, Lanoë C, Houdé O, Borst G. Inhibitory control is needed for the resolution of arithmetic word problems: a developmental negative priming study. J Educ Psychol. 2013;105 : 701–8.
4. Marzocchi GM. Lucangeli D, De Meo T, Fini F, Comoldi C. The disturbing effect of irrelevant information on arithmetic problem solving in inattentive children. Dev Neuropsychol. 2002;21 : 73–92. doi: 10.1207/S15326942DN2101_4 12058836
5. Bailey CE. Cognitive accuracy and intelligent executive function in the brain and in business. Ann N Y Acad Sci. 2007;1118 : 122–41. doi: 10.1196/annals.1412.011 17717092
6. Moffitt TE, Arseneault L, Belsky D, Dickson N, Hancox RJ, Harrington H, et al. A gradient of childhood self-control predicts health, wealth, and public safety. Proc. Natl. Acad. Sci. U.S.A. 2011;108 : 2693–8. doi: 10.1073/pnas.1010076108 21262822
7. Miller HV, Barnes JC, Beaver KM. Self-control and health outcomes in a nationally representative sample. Am J Health Behav 2011;35(1): 15–27. 20950155
8. Riggs NR, Spruijt-Metz D, Sakuma K-L, Chou C-P, Pentz MA. Executive cognitive function and food intake in children. J Nutr Educ Behav. 2010;42 : 398–403. doi: 10.1016/j.jneb.2009.11.003 20719568
9. Brown TE, Landgraf JM. Improvements in executive function correlate with enhanced performance and functioning and health-related quality of life: Evidence from 2 large, double-blind, randomized, placebo-controlled trials in ADHD. Postgraduate Medicine. 2010;122(5): 42–51. doi: 10.3810/pgm.2010.09.2200 20861587
10. Davis JC, Marra CA, Najafzadeh M, Lui-Ambrose T. The independent contribution of executive functions to health related quality of life in older women. BMC Geriatr. 2010;10(1): 16–23.
11. Moffitt TE. Childhood self-control predicts adult health, wealth, and crime. Trygfonden Multi-Disciplinary Symposium Improving the Well-Being of Children and Youth. Copenhagen.2012.
12. Alloway TP, Alloway RG. Investigating the predictive roles of working memory and IQ in academic attainment. J Exp Child Psychol. 2010;106 : 20–9. doi: 10.1016/j.jecp.2009.11.003 20018296
13. Duckworth AL, Seligman MEP. Self-discipline outdoes IQ in predicting academic performance of adolescents. Psychol Sci. 2005;16 : 939–44. doi: 10.1111/j.1467-9280.2005.01641.x 16313657
14. Evans GW, Rosenbaum J. Self-regulation and the income achievement gap. Early Child Res Q. 2008;23 : 504–14.
15. O’Shaughnessy T, Lane KL, Gresham FM, Beebe-Frankenberger M. Children placed at risk for learning and behavioral difficulties: Implementing a school-wide system of early identification and prevention. Remedial Spec Educ. 2003;24 : 27–35.
16. Asada Y, Yoshida Y, Whipp AM. Summarizing social disparities in health. Milbank Q. 2013;91(1): 5–36. doi: 10.1111/milq.12001 23488710
17. Hertzman C, Boyce T. How experience gets under the skin to create gradients in developmental health. Annu Rev Public Health. 2010;31(1): 329–47.
18. Durlak JA, Weissberg RP, Dymnicki AB, Taylor RD, & Schellinger KB. The impact of enhancing students’ social and emotional learning: a meta-analysis of school-based universal interventions. Child Dev. 2011;82 : 405–32. doi: 10.1111/j.1467-8624.2010.01564.x 21291449
19. Jones DE, Greenberg MT, Crowley M. Early social-emotional functioning and public health: The relationship between kindergarten social competence and future wellness. Am J Public Health. 2015;105 : 2283–90. doi: 10.2105/AJPH.2015.302630 26180975
20. Kiuru N, Aunola K, Lerkkanen MK, Pakarinen E, Poskiparta E, Ahonen T, et al. Positive teacher and peer relations combine to predict primary school students’ academic skill development. Dev Psychol. 2015;51 : 434–46. doi: 10.1037/a0038911 25751095
21. Zins JE, Bloodworth MR. Weissberg RP, Walberg HJ. The scientific base linking social and emotional learning to school success. J Educ Psychol Consult. 2007;17 : 191–210.
22. Manrique M, Allwood MA, Pugach CP, Amoh N, Cerbone A. Time and support do not heal all wounds: Mental health correlates of past bullying among college students. J Am Coll Health. 2019 : 1–9.
23. Schoeler T, Duncan L, Cecil CM, Ploubidis GB, Pingault J-B. Quasi-experimental evidence on short - and long-term consequences of bullying victimization: A meta-analysis. Psychol Bull. 2018;144 : 1229–46. doi: 10.1037/bul0000171 30475016
24. Haynes M. On the path to equity: Improving the effectiveness of beginning teachers. Alliance for Excellent Education Brief Online J. 2014;14 : 1–17.
25. Aloe AM, Amo LC, Shanahan ME. Classroom management self efficacy and burnout: a multivariate meta-analysis. Educ Psychol Rev. 2014;26(1): 101–26.
26. Heinemann LV, Heinemann T. Burnout research: Emergence and scientific investigation of a contested diagnosis. SAGE Open. 2017;7 : 1–12.
27. Bierman KL, Nix RL, Greenberg MT, Blair C, Domitrovich CE. Executive function and school readiness intervention: impact, moderation and mediation in the head start REDI program. Dev Psychopathol. 2008;20 : 821–43. doi: 10.1017/S0954579408000394 18606033
28. Curby TW, Brown CA, Bassett HH, Denham SA. Associations between preschoolers’ social-emotional competence and preliteracy skills. Infant Child Dev. 2015;24 : 549–70.
29. Denham SA, Bassett HH, Brown C, Way E, Steed J. “I know how you feel”: preschoolers’ emotion knowledge contributes to early school success. J Early Child Res. 2013; 13 : 252–262.
30. Espy KA, McDiarmid MM, Cwik MF, Stalets MM, Hamby A, Senn TE. The contribution of executive functions to emergent mathematic skills in preschool children. Dev Neuropsychol. 2004;26 : 465–486. doi: 10.1207/s15326942dn2601_6 15276905
31. McClelland MM, Acock AC, Piccinin A, Rhea SA, Stallings MC. Relations between preschool attention span-persistence and age 25 educational outcomes. Early Child Res Q. 2013;28 : 314–324. doi: 10.1016/j.ecresq.2012.07.008 23543916
32. Watts TW, Gandhi J, Ibrahim DA, Masucci MD, Raver CC. The Chicago School Readiness Project: examining the long-term impacts of an early childhood intervention. PLoS One. 2018;13: e0200144. doi: 10.1371/journal.pone.0200144 30001339
33. Chetty R, Friedman JN, Hilger N, Saez E, Schanzenbach DW, Yagan D. How does your kindergarten classroom affect your earnings? Evidence from Project STAR. Q J Econ. 2011; 126 : 1593–1660. 22256342
34. Diamond A. Executive functions. Annu Rev Psychol. 2013;64 : 135–68. doi: 10.1146/annurev-psych-113011-143750 23020641
35. Nakamichi K. Differences in young children’s peer preference by inhibitory control and emotion regulation. Psychol Rep. 2017; 120 : 805–23.
36. Rhoades BL, Greenberg MT, Domitrovich CE. The contribution of inhibitory control to preschoolers’ social-emotional competence. J Appl Dev Psychol. 2009;30 : 310–20.
37. Riggs NR, Jahromi LB, Razza RP, Dillworth-Bart JE, Mueller U. Executive function and the promotion of social-emotional competence. J Appl Dev Psychol. 2006;27 : 300–9.
38. Blair C, McKinnon RD, Family Life Project Investigators. Moderating effects of executive functions and the teacher-child relationship on the development of mathematics ability in kindergarten. Learn Instr. 2016;41 : 85–93.
39. Ladd GW, Birch SH, Buhs ES. Children’s social and scholastic lives in kindergarten: related spheres of influence? Child Dev. 1999;70 : 1373–400. 10621962
40. Rotenberg KJ, Michalik N, Eisenberg N, Betts LR. The relations among young children’s peer-reported trustworthiness, inhibitory control, and preschool adjustment. Early Child Res Q. 2008;23 : 288–98. doi: 10.1016/j.ecresq.2007.04.003 18846246
41. Baumeister RF, DeWall CN, Ciarocco NJ, Twenge JM. Social exclusion impairs self-regulation. J Pers Soc Psychol. 2005;88 : 589–604. doi: 10.1037/0022-3514.88.4.589 15796662
42. Cacioppo J, Patrick W. Loneliness: Human nature and the need for social connection. New York, NY: W. W. Norton & Co., Inc.; 2008.
43. Layden EA, Cacioppo JT, Cacioppo S, Cappa SF, Dodich A, Falini A, et al. Perceived social isolation is associated with altered functional connectivity in neural networks associated with tonic alertness and executive control. Neuroimage. 2017;145 : 58–73. doi: 10.1016/j.neuroimage.2016.09.050 27664824
44. Benner AD. Latino adolescents’ loneliness, academic performance, and the buffering nature of friendships. J Youth Adolesc. 2011;40 : 556–67. doi: 10.1007/s10964-010-9561-2 20571900
45. Miller G. Why loneliness is hazardous to your health. Science. 2011;331(6014): 138–40. doi: 10.1126/science.331.6014.138 21233358
46. Lynch JJ. Broken heart: the medical consequences of loneliness. New York: Basic Books; 1977.
47. Lyyra N, Välimaa R, Tynjälä J. Loneliness and subjective health complaints among school-aged children. Scand J Public Health. 2018;46 : 87–93. doi: 10.1177/1403494817743901 29552967
48. Arnsten AFT. Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci. 2009;10 : 410–22. doi: 10.1038/nrn2648 19455173
49. Duckworth AL, Kim B, Tsukayama E. Life stress impairs self-control in early adolescence. Front Psychol. 2013;3(608): 1–12.
50. Liston C, McEwen BS, Casey BJ. Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Proc. Natl. Acad. Sci. U.S.A. 2009;106 : 912–7. doi: 10.1073/pnas.0807041106 19139412
51. Kauts A, Sharma N. Effect of yoga on academic performance in relation to stress. Int J Yoga. 2009;2(1): 39–43. doi: 10.4103/0973-6131.53860 21234215
52. Ng V, Koh D, Chia SE. Examination stress, salivary cortisol, and academic performance. Psychol Rep. 2003;93 : 1133–4. doi: 10.2466/pr0.2003.93.3f.1133 14765582
53. Sheridan CL, Smith LK. Stress and academic achievement in teenagers: assessment and intervention. J Psychosom Res. 1987;34(2): 20–4.
54. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. JAMA. 2007;298 : 1685–7. doi: 10.1001/jama.298.14.1685 17925521
55. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc. Natl. Acad. Sci. U.S.A. 2012;109 : 5995–9. doi: 10.1073/pnas.1118355109 22474371
56. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130 : 601–30. doi: 10.1037/0033-2909.130.4.601 15250815
57. Ashby F, Isen A, Turken A. A neuropsychological theory of positive affect and its influence on cognition. Psychol Rev. 1999;106 : 529–50. 10467897
58. Hirt ER, Devers EE, McCrea SM. I want to be creative: Exploring the role of hedonic contingency theory in the positive mood-cognitive flexibility link. J Pers Soc Psychol. 2008;94 : 214–30. doi: 10.1037/0022-3514.94.2.94.2.214 18211173
59. von Hecker U, Meiser T. Defocused attention in depressed mood: Evidence from source monitoring. Emotion. 2005;5 : 456–63. doi: 10.1037/1528-3542.5.4.456 16366749
60. Kavanagh DJ, Bower GH. Mood and self-efficacy: Impact of joy and sadness on perceived capacities. Cognit Ther Res. 1985;9 : 507–25.
61. Noddings N. The challenge to care in schools: an alternative approach to education. New York: Teacher College, Columbia University; 2005.
62. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. 2005;24 : 297–306. doi: 10.1037/0278-6133.24.3.297 15898866
63. Rosenkranz MA, Jackson DC, Dalton KM, Dolski I, Ryff CD, Singer BH, et al. Affective style and in vivo immune response: neurobehavioral mechanisms. Proc. Natl. Acad. Sci. U.S.A. 2003;100 : 11148–52. doi: 10.1073/pnas.1534743100 12960387
64. Slavish DC, Graham-Engeland JE. Rumination mediates the relationships between depressed mood and both sleep quality and self-reported health in young adults. J Behav Med. 2015;38 : 204–13. doi: 10.1007/s10865-014-9595-0 25195078
65. Steptoe A, Wardle J, Marmot M, McEwen BS. Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes. Proc. Natl. Acad. Sci. U.S.A. 2005;102 : 6508–12. doi: 10.1073/pnas.0409174102 15840727
66. Malti T, Gummerum M, Keller M, Buchmann M. Childrens moral motivation, sympathy, and prosocial behavior. Child Dev. 2009;80 : 442–60. doi: 10.1111/j.1467-8624.2009.01271.x 19467003
67. Blair C, McKinnon RD, & Daneri MP. Effect of the Tools of the Mind kindergarten program on children’s social and emotional development. Early Child Res Q. 2018;43 : 52–61.
68. Blair C, Raver C. Closing the achievement gap through modification of neurocognitive and neuroendocrine function: Results from a cluster randomized controlled trial of an innovative approach to the education of children in kindergarten. PLoS One. 2014;9: e112393. doi: 10.1371/journal.pone.0112393 25389751
69. Diamond A, Barnett WS, Thomas J, Munro S. Preschool program improves cognitive control. Science. 2007;318 : 1387–8. doi: 10.1126/science.1151148 18048670
70. Clements CH, Sarama J. Experimental evaluation of the effects of a research-based preschool mathematics. Am Educ Res J. 2008;45 : 443–94.
71. Morris P, Mattera SK, Castells N, Bangser M, Bierman K, Raver C. Impact findings from the head start cares demonstration: national evaluation of three approaches to improving preschoolers’ social and emotional competence. Washington, DC: OPRE, ACF, US Department of Health and Human Services; 2014.
72. Solomon TLS, Plamondon A, O’Hara A, Finch H, Goco G, Chaban P, et al. A cluster randomized-controlled trial of the impact of the Tools of the Mind curriculum on self-regulation in Canadian preschoolers. Front Psychol. 2017;8 : 18.
73. Chapman M, Balabanov R, Bischoff C, Dean H, Denyer D, Jesten B, et al. Primary Program: A Framework for Teaching. Victoria, BC: Ministry of Education; 2000.
74. Committee for Children. Second Step: A violence prevention curriculum. Preschool/ kindergarten teacher’s guide (3rd ed.). Committee for Children Publishers; 2002.
75. Maloney JE, Lawlor MS, Schonert-Reichl KA, Whitehead J. A mindfulness-based social and emotional learning curriculum for school-aged children: the MindUP program. In: Schonert-Reichl KA, Roeser RW, editors. Mindfulness in Education: Integrating theory and research into practice. New York, NY: Springer Press Editors; 2016.
76. Bodrova E, Leong DJ. Tools of the Mind: the Vygotskian approach to early childhood education (2nd ed.). NY: Merrill/Prentice Hall; 2007.
77. Vygotsky LS. Play and its role in the mental development of the child. Soviet Psychology. 1967;7 : 6–18.
78. Vygotsky LS. Mind in society: the development of higher psychological processes. Cambridge, MA: Harvard University Press; 1978.
79. Berk LE. Children’s private speech: an overview of theory and status of research. In: Diaz RM, Berk LE, editors. Private speech: from social interaction to self-regulation. Hillsdale, NJ: Erlbaum; 1992. p. 17–53.
80. Fernyhough C, Fradley E. Private speech on an executive task: relations with task difficulty and task performance. Cogn Dev. 2005;20 : 103–20.
81. Freeman S, Eddy SL, McDonough M, Smith MK, Okoroafor N, Jordt H, et al. Active learning increases student performance in science, engineering, and mathematics. Proc. Natl. Acad. Sci. U.S.A. 2014;111 : 8410–5. doi: 10.1073/pnas.1319030111 24821756
82. Karpicke JD. Retrieval-based learning: active retrieval promotes meaningful learning. Curr Dir Psychol Sci. 2012;21(3): 157–63.
83. Government of British Columbia. Teaching and assessment tools. Retrieved Feb 25, 2019 from https://www2.gov.bc.ca/gov/content/education-training/early-learning/teach/teaching-and-assessment-tools.
84. Beaver J. DRA2: Developmental Reading Assessment. Parsippany, N.J: Celebration Press, 2006.
85. Brouwers A, Tomic W. A longitudinal study of teacher burnout and perceived self-efficacy in classroom management. Teach Teach Educ. 2000;16 : 239–53.
86. Duncan GJ, Dowsett CJ, Claessens A, Magnuson K, Huston AC, Klebanov P, et al. School readiness and later achievement. Dev Psychol. 2007; 43 : 1428–46. doi: 10.1037/0012-1649.43.6.1428 18020822
87. Merrell C, Tymms PB. Inattention, hyperactivity, and impulsiveness: their impact on academic achievement and progress. Br J Educ Psychol. 2001;71 : 43–56. 11307708
88. Ryan RM, Deci EL. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. Am Psychol. 2000;55(1): 68–78. 11392867
89. Lonigan C. Presentation in Session on “Enhancing Executive Function and Achievement in Prekindergarten Classrooms: The Effectiveness of Tools of the Mind” at Society for Research on Educational Effectiveness (SREE) Conference on Understanding Variations in Treatment Effects. Washington, DC, March 8, 2012.
90. Wilson SJ, Farran D. Presentation in Session on “Enhancing Executive Function and Achievement in Prekindergarten Classrooms: The Effectiveness of Tools of the Mind” at Society for Research on Educational Effectiveness (SREE) Conference on Understanding Variations in Treatment Effects. Washington, DC, March 8, 2012.
91. Holmes J, Gathercole SE, Dunning DL. Adaptive training leads to sustained enhancement of poor working memory in children. Dev Sci. 2009;12: F9–F15. doi: 10.1111/j.1467-7687.2009.00848.x 19635074
92. Marcon RA. Moving up the grades: Relationship between preschool model and later school success. Early Childhood Research & Practice. 2002;4(1).
93. Lillard A, Heise M, Richey E, Tong X, Hart A, Bray P. Montessori preschool elevates and equalizes child outcomes: A longitudinal study. Frontiers in Psychology. 2017;8 : 1–19.
94. Holochwost SJ, Propper CB, Wolf DP, Willoughby MT, Fisher KR, Kolacz J, et al. Music education, academic achievement, and executive functions. Psychology of Aesthetics, Creativity, and the Arts. 2017;11 : 147–66.
95. Sy A, Glanz K. Factors influencing teachers’ implementation of an innovative tobacco prevention curriculum for multiethnic youth: Project SPLASH. J Sch Health. 2008;78 : 264–73. doi: 10.1111/j.1746-1561.2008.00299.x 18387026
96. Witt JC. Teachers’ resistance to the use of school-based interventions. J Sch Health Psychol. 1986;24 : 37–44.
97. Witt JC, Martens BK. Assessing the acceptability of behavioral interventions used in classrooms. Psychol Sch. 1983;20 : 510–17.
98. Bassok D, Latham S, Rorem A. Is kindergarten the new first grade? AERA Open. 2016;1(4): 1–31.
99. Miller E, Almon J. Crisis in the kindergarten: why children need to play in school. College Park, MD: Alliance for Childhood. 2009.
100. Lillard AS. Montessori: the science behind the genius. NYC: Oxford University Press. 2005.
101. Arnsten AFT, Raskind MA, Taylor FB, Connor DF. The effects of stress exposure on prefrontal cortex: translating basic research into successful treatments for post-traumatic stress disorder. Neurobiol Stress. 2015 : 1: 89–99. doi: 10.1016/j.ynstr.2014.10.002 25436222
102. Maier SU, Makwana AB, Hare TA. Acute stress impairs self-control in goal-directed choice by altering multiple functional connections within the brain’s decision circuits. Neuron. 2015;87 : 621–31. doi: 10.1016/j.neuron.2015.07.005 26247866
103. Olver JS, Pinney M, Maruff P, Norman TR. Impairments of spatial working memory and attention following acute psychosocial stress. Stress Health. 2015;31 : 115–23. doi: 10.1002/smi.2533 24395182
104. Ryan SV, von der Embse NP, Pendergast LL, Saeki E, Segool N, Schwing S. Leaving the teaching profession: the role of teacher stress and educational accountability policies on turnover intent. Teach Teach Educ. 2017;66 : 1–11.
105. Mahler D, Großschedl J, Harms U. Does motivation matter?–The relationship between teachers’ self-efficacy and enthusiasm and students’ performance. PLoS One. 2018;13: e0207252. doi: 10.1371/journal.pone.0207252 30462713
106. Maslach C, Leiter MP. Understanding the burnout experience: recent research and its implications for psychiatry. World Psychiatry. 2016;15 : 103–11. doi: 10.1002/wps.20311 27265691
107. Ahola K, Hakanen J. Burnout and health. In Leiter MP, Bakker AB, Maslach C, editors. Burnout at work: a psychological perspective. London: Psychology Press. 2014 : 10–31.
Článek Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviourČlánek Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershedČlánek Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitroČlánek Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor dataČlánek Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanismsČlánek Free will beliefs are better predicted by dualism than determinism beliefs across different culturesČlánek The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangarooČlánek The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6AČlánek Myotendinous asymmetries derived from the prolonged practice of badminton in professional playersČlánek Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylationČlánek Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-UgandaČlánek Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomesČlánek uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading framesČlánek Medicine and the media: Medical experts’ problems and solutions while working with journalistsČlánek Primary hyperhidrosis prevalence and characteristics among medical students in Rio de JaneiroČlánek Antibacterial activity of silver nanoparticles of different particle size against Vibrio NatriegensČlánek Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysisČlánek Association between the posterior part of the circle of Willis and the vertebral artery hypoplasiaČlánek Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitisČlánek Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizineČlánek The intake pattern and feed preference of layer hens selected for high or low feed conversion ratioČlánek Individualized pattern recognition for detecting mind wandering from EEG during live lecturesČlánek Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapyČlánek Feeling the heat: Elevated temperature affects male display activity of a lekking grassland birdČlánek A zero-shot learning approach to the development of brain-computer interfaces for image retrievalČlánek Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogsČlánek Supplementation strategies affect the feed intake and performance of grazing replacement heifersČlánek Prediction of cardiovascular disease risk among people with severe mental illness: A cohort studyČlánek Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approachČlánek Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)Článek Correction: Unraveling the genetic complexity underlying sorghum response to water availabilityČlánek Is this a man’s world? The effect of gender diversity and gender equality on firm innovativenessČlánek Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cellsČlánek Correction: The prognosis of heart failure patients: Does sodium level play a significant role?Článek Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal populationČlánek The impact of admission serum lactate on children with moderate to severe traumatic brain injuryČlánek PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophilsČlánek Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.Článek Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small IntestineČlánek Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebratesČlánek The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables testČlánek Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulationČlánek Differences in the impedance of cochlear implant devices within 24 hours of their implantationČlánek Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012Článek Organic resolution function and effects of platinum nanoparticles on bacteria and organic matterČlánek Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responsesČlánek National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015Článek Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in MalaysiaČlánek Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissuesČlánek Time-related immunomodulation by stressors and corticosterone transdermal application in toadsČlánek Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radioČlánek Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?Článek Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal dietČlánek Human papillomavirus infection among head and neck squamous cell carcinomas in southern ChinaČlánek Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification dataČlánek The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacityČlánek LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancerČlánek Global smoking trends in inflammatory bowel disease: A systematic review of inception cohortsČlánek A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)Článek Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1Článek Advancing computational biology and bioinformatics research through open innovation competitionsČlánek A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic dietČlánek The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class dataČlánek A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiataČlánek Self-management action and motivation of Pacific adults in New Zealand with end-stage renal diseaseČlánek The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workersČlánek In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysisČlánek The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?Článek Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decompositionČlánek Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort studyČlánek Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seekingČlánek Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational studyČlánek Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation taskČlánek Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equationČlánek Sign and goal tracker rats process differently the incentive salience of a conditioned stimulusČlánek Resource consumption of multi-substance users in the emergency room: A neglected patient groupČlánek Modeling spatial variation in density of golden eagle nest sites in the western United StatesČlánek Correction: Development of a high-throughput assay to measure measles neutralizing antibodiesČlánek Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problemČlánek Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiotaČlánek DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
Článok vyšiel v časopisePLOS One
Najčítanejšie tento týždeň
2019 Číslo 9- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Masturbační chování žen v ČR − dotazníková studie
- Postup rychlého zotavení po operaci zlomeniny krčku femuru
- Nejasný stín na plicích – kazuistika
- Flibanserin není ženská Viagra
-
Všetky články tohto čísla
- "The dead shall be raised": Multidisciplinary analysis of human skeletons reveals complexity in 19th century immigrant socioeconomic history and identity in New Haven, Connecticut
- Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviour
- The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study
- Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis
- Expression profile of genes encoding allatoregulatory neuropeptides in females of the spider Parasteatoda tepidariorum (Araneae, Theridiidae)
- “My life after stroke through a camera lens”- A photovoice study on participation in Sweden
- Bacterial community composition of biofilms in milking machines of two dairy farms assessed by a combination of culture-dependent and –independent methods
- Health differences between multiple and single job holders in precarious employment in the Netherlands: A cross-sectional study among Dutch workers
- Clinical evaluation and budget impact analysis of cervical cancer screening using cobas 4800 HPV screening technology in the public sector of South Africa
- Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershed
- High-throughput sequencing analysis of microbial community diversity in response to indica and japonica bar-transgenic rice paddy soils
- Physiological and molecular responses to drought stress in teak (Tectona grandis L.f.)
- Long-term performance of an atrial lead capable of accelerometer based detection of cardiac contractility in patients receiving cardiac resynchronisation therapy
- Ectomycorrhizal fungal communities of secondary tropical forests dominated by Tristaniopsis in Bangka Island, Indonesia
- Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice
- Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology
- Xenopus fraseri: Mr. Fraser, where did your frog come from?
- Competing priorities and second chances - A qualitative exploration of prisoners’ journeys through the Hepatitis C continuum of care
- Evaluating coral trophic strategies using fatty acid composition and indices
- Amyloid β oligomers inhibit growth of human cancer cells
- Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis
- Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women
- 'He usually has what we call normal fevers’: Cultural perspectives on healthy child growth in rural Southeastern Tanzania: An ethnographic enquiry
- Anatomical connections underlying personally-familiar face processing
- Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana
- Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
- Correction: Development of interval-valued fuzzy GRA with SERVPERF based on subjective and objective weights for evaluation of airline service quality: A case study of Korea low-cost carriers
- Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line
- Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects
- Structuring a conceptual model for cost-effectiveness analysis of frailty interventions
- Characteristics of sarcopenia after distal gastrectomy in elderly patients
- Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)
- The determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT
- Taste perception and oral microbiota are associated with obesity in children and adolescents
- Target women: Equity in access to mHealth technology in a non-communicable disease care intervention in Kenya
- Correction: Attitudes to and experiences with body weight control and changes in body weight in relation to all-cause mortality in the general population
- Homogenous HIV-1 subtype B from the Brazilian Amazon with infrequent diverse BF1 recombinants, subtypes F1 and C among blood donors
- Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes
- Loss of control as a violation of expectations: Testing the predictions of a common inconsistency compensation approach in an inclusionary cyberball game
- Living on the edge - circadian habitat usage in pre-weaning European hares (Lepus europaeus) in an intensively used agricultural area
- NMDA receptor activation induces long-term potentiation of glycine synapses
- Antibody response in snakes with boid inclusion body disease
- Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates
- Affirmative citation bias in scientific myth debunking: A three-in-one case study
- Streaming chunk incremental learning for class-wise data stream classification with fast learning speed and low structural complexity
- Time trends in healthy lifestyle among adults in Germany: Results from three national health interview and examination surveys between 1990 and 2011
- The impact of door-to-electrocardiogram time on door-to-balloon time after achieving the guideline-recommended target rate
- A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
- Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro
- CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress
- Multi-method assessment of whale shark (Rhincodon typus) residency, distribution, and dispersal behavior at an aggregation site in the Red Sea
- Duration of symptoms in the quantification of upper limb disability and impairment for individuals with mild degenerative cervical myelopathy (DCM)
- Expression of genes in the skeletal muscle of individuals with cachexia/sarcopenia: A systematic review
- Correction: Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
- Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort
- Estimation of the incidence of animal rabies in Punjab, India
- G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells
- Reasons behind stymied public hospital governance reform in China
- Cognitive and social congruence in peer-assisted learning – A scoping review
- The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU
- Associations between sexual activity and weight status: Findings from the English Longitudinal Study of Ageing
- Knowledge and practices regarding toxoplasmosis in housewives: A cross sectional study in a northern Mexican city
- Citation gaming induced by bibliometric evaluation: A country-level comparative analysis
- Can we predict which species win when new habitat becomes available?
- Wetlands are keystone habitats for jaguars in an intercontinental biodiversity hotspot
- Research applications of primary biodiversity databases in the digital age
- The Edinburgh Postpartum Depression Scale: Stable structure but subscale of limited value to detect anxiety
- EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation
- Post-exercise high-sensitivity troponin T levels in patients with suspected unstable angina
- Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor data
- Development of highly sensitive and low-cost DNA agarose gel electrophoresis detection systems, and evaluation of non-mutagenic and loading dye-type DNA-staining reagents
- Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
- Macrophage phenotype and its relationship with renal function in human diabetic nephropathy
- Phylogeography of the dugong (Dugong dugon) based on historical samples identifies vulnerable Indian Ocean populations
- Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanisms
- Evaluation of the effectiveness and equity of the maternity protection reform in Chile from 2000 to 2015
- Baseline human gut microbiota profile in healthy people and standard reporting template
- Are screening methods useful in feature selection? An empirical study
- Free will beliefs are better predicted by dualism than determinism beliefs across different cultures
- How does the content of nutrients in soil affect the health status of trees in city parks?
- Understanding the intricacy of canid social systems: Structure and temporal stability of red fox (Vulpes vulpes) groups
- The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangaroo
- Nurse-led medicines’ monitoring in care homes, implementing the Adverse Drug Reaction (ADRe) Profile improvement initiative for mental health medicines: An observational and interview study
- Projecting burden of hypertension and its management in Turkey, 2015-2030
- Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
- Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
- Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort
- Understanding the effect of producers’ attitudes, perceived norms, and perceived behavioral control on intentions to use antimicrobials prudently on New York dairy farms
- Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
- Theory of mind in remitted bipolar disorder: Interpersonal accuracy in recognition of dynamic nonverbal signals
- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- Ecological conditions experienced by offspring during pregnancy and early post-natal life determine mandible size in roe deer
- Calculation of the contribution rate of China’s hydraulic science and technology based on a feedforward neural network
- ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples
- The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice
- Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis
- Moving model analysis on the transient pressure and slipstream caused by a metro train passing through a tunnel
- The importance of assigning responsibility during evaluation in order to increase student satisfaction from physical education classes: A structural equation model
- Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall
- Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans
- Proteomics approach to identify serum biomarkers associated with the progression of diabetes in Korean patients with abdominal obesity
- Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
- Transcriptome analysis of a nematode resistant and susceptible upland cotton line at two critical stages of Meloidogyne incognita infection and development
- Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies
- Distinguishing mild cognitive impairment from healthy aging and Alzheimer’s Disease: The contribution of the INECO Frontal Screening (IFS)
- Novel application of amino-acid buffered solution for neuroprotection against ischemia/reperfusion injury
- Are unpopular children more likely to get sick? Longitudinal links between popularity and infectious diseases in early childhood
- Vegetation communities on commercial developments are heterogenous and determined by development and landscaping decisions, not socioeconomics
- Falls among community-dwelling older adults in Ethiopia; A preliminary cross-sectional study
- Retraction: Social success of perfumes
- The effect of ethyl alcohol on the severity of injuries in fatal pedestrian victims of traffic crashes
- Drought stress has transgenerational effects on soybean seed germination and seedling vigor
- Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI
- Age-related differences of inter-joint coordination in elderly during squat jumping
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Diagnostic performance and image quality of iterative model-based reconstruction of coronary CT angiography using 100 kVp for heavily calcified coronary vessels
- CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer
- Getting your game on: Using virtual reality to improve real table tennis skills
- Microbiological contamination of young children’s hands in rural Bangladesh: Associations with child age and observed hand cleanliness as proxy
- Expansion of the agricultural frontier in the largest South American Dry Forest: Identifying priority conservation areas for snakes before everything is lost
- Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement
- Aerial surveys cause large but ephemeral decreases in bear presence at salmon streams in Kodiak, Alaska
- Exposure to particle debris generated from passenger and truck tires induces different genotoxicity and inflammatory responses in the RAW 264.7 cell line
- Influence of the cultivation medium and pH on the pigmentation of Trichophyton rubrum
- Intra-arterial catheter-directed CT angiography for assessment of endovascular aortic aneurysm repair
- Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study
- The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A
- Plasma chemistry in nesting leatherback sea turtles (Dermochelys coriacea) from Florida: Understanding the importance of sample hemolysis effects on blood analytes
- Myotendinous asymmetries derived from the prolonged practice of badminton in professional players
- Computational tools to detect signatures of mutational processes in DNA from tumours: A review and empirical comparison of performance
- Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice
- Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it
- Comparative compositional and functional analyses of Bothrops moojeni specimens reveal several individual variations
- Radiation hardness of cadmium telluride solar cells in proton therapy beam mode
- Bourdieu, networks, and movements: Using the concepts of habitus, field and capital to understand a network analysis of gender differences in undergraduate physics
- A 32-channel parallel transmit system add-on for 7T MRI
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Knowledge gaps of STIs in Africa; Systematic review
- Correction: Bovine herpesvirus 1 can cross the intact zona pellucida of bovine oocytes after artificial infection
- Distribution of corneal spherical aberration in a Tanzanian population
- Correction: Determinants of physical activity: A path model based on an ecological model of active living
- Wild pollinator activity negatively related to honey bee colony densities in urban context
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status
- The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
- Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
- Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
- Construction of pseudomolecule sequences of Brassica rapa ssp. pekinensis inbred line CT001 and analysis of spontaneous mutations derived via sexual propagation
- Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function
- Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
- Comparing infiltration rates in soils managed with conventional and alternative farming methods: A meta-analysis
- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
- The complete mitochondrial genome of Calyptogena marissinica (Heterodonta: Veneroida: Vesicomyidae): Insight into the deep-sea adaptive evolution of vesicomyids
- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
- Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
- “…or else I close my ears” How women with obesity want to be approached and treated regarding gestational weight management: A qualitative interview study
- Does a spinal implant alter dual energy X-ray absorptiometry body composition measurements?
- Economic and livestock health impacts of birds on dairies: Evidence from a survey of Washington dairy operators
- Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials
- Shifts in temperature influence how Batrachochytrium dendrobatidis infects amphibian larvae
- Sequential two-step chromatographic purification of infectious poliovirus using ceramic fluoroapatite and ceramic hydroxyapatite columns
- Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study
- Differences in the impedance of cochlear implant devices within 24 hours of their implantation
- Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion
- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
- Addis Ababa population-based pattern of cancer therapy, Ethiopia
- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
- Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
- DNA barcoding of coastal ray-finned fishes in Vietnam
- Comparison of climbing-specific strength and endurance between lead and boulder climbers
- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
- Analgesic drug use in elderly persons: A population-based study in Southern Italy
- RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity
- Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012
- A non-parametric significance test to compare corpora
- Evaluating the impact of policies recommending PrEP to subpopulations of men and transgender women who have sex with men based on demographic and behavioral risk factors
- Different levels of statistical learning - Hidden potentials of sequence learning tasks
- Dry period heat stress induces microstructural changes in the lactating mammary gland
- Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter
- High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
- Dynamic up- and down-regulation of the default (DMN) and extrinsic (EMN) mode networks during alternating task-on and task-off periods
- ERK1/ATF-2 signaling axis contributes to interleukin-1β-induced MMP-3 expression in dermal fibroblasts
- Cytokine profiles of umbilical cord blood mononuclear cells upon in vitro stimulation with lipopolysaccharides of different vaginal gram-negative bacteria
- Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
- Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis
- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
- Soil respiration from fields under three crop rotation treatments and three straw retention treatments
- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
- Linkage disequilibrium and haplotype block patterns in popcorn populations
- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
- Accuracy of Determine TB-LAM Ag to detect TB in HIV infected patients associated with diagnostic methods used in Brazilian public health units
- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
- Coralline algal calcification: A morphological and process-based understanding
- Comparing record linkage software programs and algorithms using real-world data
- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
- Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming
- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
- LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer
- Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh
- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
- Friends, relatives, sanity, and health: The costs of politics
- European public perceptions of homelessness: A knowledge, attitudes and practices survey
- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
- Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low and intermediate risk: A risk specific meta-analysis of randomized controlled trials
- Global smoking trends in inflammatory bowel disease: A systematic review of inception cohorts
- Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study
- Genomic analyses reveal an absence of contemporary introgressive admixture between fin whales and blue whales, despite known hybrids
- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
- Advancing computational biology and bioinformatics research through open innovation competitions
- Dynamic changes in the physicochemical properties of fresh-cut produce wash water as impacted by commodity type and processing conditions
- Mapping online hate: A scientometric analysis on research trends and hotspots in research on online hate
- Orthogonal projection to latent structures and first derivative for manipulation of PLSR and SVR chemometric models' prediction: A case study
- DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
- Malaria transmission through the mosquito requires the function of the OMD protein
- Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
- Governing Tripolye: Integrative architecture in Tripolye settlements
- In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis
- Mortality, perception, and scale: Understanding how predation shapes space use in a wild prey population
- DNA analysis of elasmobranch products originating from Bangladesh reveals unregulated elasmobranch fishery and trade on species of global conservation concern
- Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)
- A spherical falling film gas-liquid equilibrator for rapid and continuous measurements of CO2 and other trace gases
- The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
- Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents
- A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
- De novo transcriptome analysis of Viola ×wittrockiana exposed to high temperature stress
- Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
- HMGB1 mediates the development of tendinopathy due to mechanical overloading
- Effects of the Best Possible Self intervention: A systematic review and meta-analysis
- Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri
- Adjusting cotton planting density under the climatic conditions of Henan Province, China
- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
- PTSD in prison settings: A systematic review and meta-analysis of comorbid mental disorders and problematic behaviours
- The female presence in different organisational positions and performance in secondary schools: Does a woman leader function as mediator?
- Beta power encodes contextual estimates of temporal event probability in the human brain
- Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics
- Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
- Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit
- Predicting spinal profile using 3D non-contact surface scanning: Changes in surface topography as a predictor of internal spinal alignment
- Assessment modelling approaches for stocks with spawning components, seasonal and spatial dynamics, and limited resources for data collection
- Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
- De-climatizing food security: Lessons from climate change micro-simulations in Peru
- Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking
- An international survey of perceptions of the 2014 FIFA World Cup: National levels of corruption as a context for perceptions of institutional corruption
- Dissuasive effect, information provision, and consumer reactions to the term ‘Biotechnology’: The case of reproductive interventions in farmed fish
- "If I have a cancer, it is not my fault I am a refugee”: A qualitative study with expert stakeholders on cancer care management for Syrian refugees in Jordan
- The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study
- Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
- High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
- Evaluation of the pain intensity differences among hospitalized cancer patients based on a nursing information system
- Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
- Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning
- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
- Investigation of a spatial coupling relationship between carbon emission performance and regional urbanization in China
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
- Excellent outcome after desensitization in high immunologic risk kidney transplantation
- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
- Acute kidney injury during an ultra-distance race
- A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
- The role of C-reactive protein levels on the association of physical activity with lung function in adults
- The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class data
- Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke
- CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
- Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model
- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
- Social information use and collective foraging in a pursuit diving seabird
- Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)
- Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
- Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland
- Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada
- Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imaging
- LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells
- How do seabirds modify their search behaviour when encountering fishing boats?
- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
- Spatio-temporal variations in wheat aphid populations and their natural enemies in four agro-ecological zones of Pakistan
- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
- Self-management action and motivation of Pacific adults in New Zealand with end-stage renal disease
- Drought mediated physiological and molecular changes in muskmelon (Cucumis melo L.)
- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
- Tuberculosis in the wild boar: Frequentist and Bayesian estimations of diagnostic test parameters when Mycobacterium bovis is present in wild boars but at low prevalence
- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
- Geospatial modeling of microcephaly and zika virus spread patterns in Brazil
- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
- Reference values for the cervical spinal canal and the vertebral bodies by MRI in a general population
- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
- Incorporating statistical strategy into image analysis to estimate effects of steam and allyl isocyanate on weed control
- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
- The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers
- New space-time block codes from spectral norm
- Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients
- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
- Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
- Self Multi-Head Attention-based Convolutional Neural Networks for fake news detection
- Why are Chinese workers so unhappy? A comparative cross-national analysis of job satisfaction, job expectations, and job attributes
- Fecal indicator bacteria and virus removal in stormwater biofilters: Effects of biochar, media saturation, and field conditioning
- Personalized microstructural evaluation using a Mahalanobis-distance based outlier detection strategy on epilepsy patients’ DTI data – Theory, simulations and example cases
- Radiographic assessment of pectoral flipper bone maturation in bottlenose dolphins (Tursiops truncatus), as a novel technique to accurately estimate chronological age
- Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus
- Relative importance of gene effects for nitrogen-use efficiency in popcorn
- Comparative analysis uncovers the limitations of current molecular detection methods for Fusarium oxysporum f. sp. cubense race 4 strains
- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
- Confronting pastoralists’ knowledge of cattle breeds raised in the extensive production systems of Benin with multivariate analyses of morphological traits
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Decontamination of aerosolised bacteria from a pig farm environment using a pH neutral electrochemically activated solution (Ecas4 anolyte)
- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
- Simultaneous transcriptome analysis of oil palm clones and Phytophthora palmivora reveals oil palm defense strategies
- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
- CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants
- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- On the sustainability of a family planning program in Nigeria when funding ends
- The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes?
- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
- Seed treatment using methyl jasmonate induces resistance to rice water weevil but reduces plant growth in rice
- Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety
- Reconsidering the associations between self-reported alcohol use disorder and mental health problems in the light of co-occurring addictions in young Swiss men
- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
- Serum E-selectin concentration is associated with risk of metabolic syndrome in females
- Lipid and fatty acid dynamics by maternal Pacific bluefin tuna
- Adherence to evidence-based recommendations for surgical site infection prevention: Results among Italian surgical ward nurses
- Novel synergistic fungicidal mixtures of oxathiapiprolin protect sunflower seeds from downy mildew caused by Plasmopara halstedii
- Adjustment of a numerical model for pore pressure generation during an earthquake
- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
- Effects of turning frequency on the nutrients of Camellia oleifera shell co-compost with goat dung and evaluation of co-compost maturity
- Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers
- Distribution of SET/I2PP2A protein in gastrointestinal tissues
- Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
- Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study
- Anatomy of a demand shock: Quantitative analysis of crowding in hospital emergency departments in Victoria, Australia during the 2009 influenza pandemic
- Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms
- Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism
- Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
- Repetitive finger movement and circle drawing in persons with Parkinson’s disease
- The association between family members’ migration and cognitive function among people left behind in China
- Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults
- Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals
- Agreement between the spatiotemporal gait parameters from two different wearable devices and high-speed video analysis
- In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysis
- Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes
- Someone like me: Size-assortative pairing and mating in an Amazonian fish, sailfin tetra Crenuchus spilurus
- Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa
- Are trials of psychological and psychosocial interventions for schizophrenia and psychosis included in the NICE guidelines pragmatic? A systematic review
- Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
- Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes
- Intensity modulated radiation therapy following lumpectomy in early-stage breast cancer: Patterns of use and cost consequences among Medicare beneficiaries
- The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?
- Multiscale Modelling Tool: Mathematical modelling of collective behaviour without the maths
- A comparison of machine learning algorithms for the surveillance of autism spectrum disorder
- Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
- Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes
- Intersubject MVPD: Empirical comparison of fMRI denoising methods for connectivity analysis
- Why Cohen’s Kappa should be avoided as performance measure in classification
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager
- Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
- NPHP proteins are binding partners of nucleoporins at the base of the primary cilium
- Intensive measures of luminescence in GaN/InGaN heterostructures
- The effect of a web-based training for improving primary health care providers’ knowledge about diabetes mellitus management in rural China: A pre-post intervention study
- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
- DNA analysis of Castanea sativa (sweet chestnut) in Britain and Ireland: Elucidating European origins and genepool diversity
- Forecasting the impact of population ageing on tuberculosis incidence
- Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering
- Voxelwise statistical methods to localize practice variation in brain tumor surgery
- Identification and evolutionary characterization of salt-responsive transcription factors in the succulent halophyte Suaeda fruticosa
- Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga
- Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- Analyzing a networked social algorithm for collective selection of representative committees
- Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression
- Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
- EFForTS-LGraf: A landscape generator for creating smallholder-driven land-use mosaics
- Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system
- Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers
- Optimizing bacterial DNA extraction in urine
- Adherences to oral nutritional supplementation among hospital outpatients: An online cross-sectional survey in Japan
- Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decomposition
- Antioxidant properties of potato tubers (Solanum tuberosum L.) as a consequence of genetic potential and growing conditions
- Transcatheter aortic valve implantation versus conservative management for severe aortic stenosis in real clinical practice
- “I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists
- Automated diagnosis of heart valve degradation using novelty detection algorithms and machine learning
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study
- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
- Characterization of bony changes localized to the cervical articular processes in a mixed population of horses
- Heat shock-induced chaperoning by Hsp70 is enabled in-cell
- Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Correlates of prenatal and postnatal mother-to-infant bonding quality: A systematic review
- IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
- Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets
- How did that interaction make you feel? The relationship between quality of everyday social experiences and emotion in people with and without schizophrenia
- Effects of Lyse-It on endonuclease fragmentation, function and activity
- Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis
- Gait can reveal sleep quality with machine learning models
- Blast vacuolization in AML patients indicates adverse-risk AML and is associated with impaired survival after intensive induction chemotherapy
- Mitochondrial fragmentation and network architecture in degenerative diseases
- Quadriceps muscle strength is a discriminant predictor of dependence in daily activities in nursing home residents
- Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
- Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis
- Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
- The responses of extracellular enzyme activities and microbial community composition under nitrogen addition in an upland soil
- Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking
- Absolute pitch can be learned by some adults
- Anger while driving in Mexico City
- Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Multiple evoked and induced alpha modulations in a visual attention task: Latency, amplitude and topographical profiles
- Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women
- Serum and urinary metabolomics and outcomes in cirrhosis
- Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study
- Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
- How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
- CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters
- Pattern of health care utilization and traditional and complementary medicine use among Ebola survivors in Sierra Leone
- Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia
- Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- A usability study to improve a clinical decision support system for the prescription of antibiotic drugs
- Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
- Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review
- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
- Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality
- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
- Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation
- Group conquers efficacy: Preschoolers’ imitation under conflict between minimal group membership and behavior efficacy
- Warmth and competence stereotypes about immigrant groups in Germany
- Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study
- ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients
- Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model
- Optimum plant density for crowding stress tolerant processing sweet corn
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus
- Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
- Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam
- Scientific sinkhole: The pernicious price of formatting
- Resource consumption of multi-substance users in the emergency room: A neglected patient group
- Association between distress and knowledge among parents of autistic children
- Surgical approach for complete cochlear coverage in EAS-patients after residual hearing loss
- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
- Measurement and analysis of partial lightning currents in a head phantom
- Within species expressed genetic variability and gene expression response to different temperatures in the rotifer Brachionus calyciflorus sensu stricto
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
- Correlation of CT texture changes with treatment response during radiation therapy for esophageal cancer: An exploratory study
- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
- Gibberellic acid in Citrus spp. flowering and fruiting: A systematic review
- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
- Diagnosing the current state of out-of-field teaching in high school science and mathematics
- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
- Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
- The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum
- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
- Genetic analysis and fine mapping of a qualitative trait locus wpb1 for albino panicle branches in rice
- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
- PLOS One
- Archív čísel
- Aktuálne číslo
- Informácie o časopise
Najčítanejšie v tomto čísle- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
Prihlásenie#ADS_BOTTOM_SCRIPTS#Zabudnuté hesloZadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.
- Časopisy