An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
Authors:
Saurabh Shukla aff001; Mohd Fadzil Hassan aff001; Muhammad Khalid Khan aff002; Low Tang Jung aff001; Azlan Awang aff003
Authors place of work:
Centre for Research in Data Science (CeRDaS), Computer and Information Science Department, Universiti Teknologi PETRONAS(UTP), Seri Iskandar, Perak Darul Ridzuan, Malaysia
aff001; College of Computing and Information Sciences, PAF-KIET, Karachi, Pakistan
aff002; Electrical and Electronic Engineering Department, Universiti Teknologi PETRONAS(UTP), Seri Iskandar, Perak Darul Ridzuan, Malaysia
aff003
Published in the journal:
PLoS ONE 14(11)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0224934
Summary
Fog computing (FC) is an evolving computing technology that operates in a distributed environment. FC aims to bring cloud computing features close to edge devices. The approach is expected to fulfill the minimum latency requirement for healthcare Internet-of-Things (IoT) devices. Healthcare IoT devices generate various volumes of healthcare data. This large volume of data results in high data traffic that causes network congestion and high latency. An increase in round-trip time delay owing to large data transmission and large hop counts between IoTs and cloud servers render healthcare data meaningless and inadequate for end-users. Time-sensitive healthcare applications require real-time data. Traditional cloud servers cannot fulfill the minimum latency demands of healthcare IoT devices and end-users. Therefore, communication latency, computation latency, and network latency must be reduced for IoT data transmission. FC affords the storage, processing, and analysis of data from cloud computing to a network edge to reduce high latency. A novel solution for the abovementioned problem is proposed herein. It includes an analytical model and a hybrid fuzzy-based reinforcement learning algorithm in an FC environment. The aim is to reduce high latency among healthcare IoTs, end-users, and cloud servers. The proposed intelligent FC analytical model and algorithm use a fuzzy inference system combined with reinforcement learning and neural network evolution strategies for data packet allocation and selection in an IoT–FC environment. The approach is tested on simulators iFogSim (Net-Beans) and Spyder (Python). The obtained results indicated the better performance of the proposed approach compared with existing methods.
Keywords:
Algorithms – Computer networks – Electrocardiography – Machine learning algorithms – machine learning – Clouds – Evolutionary algorithms – Cloud computing
Introduction
The latest report by the International Data Corporation stated that the number of Internet-related sensors will increase to 30 million by 2020, and the number of Internet-of-thing (IoT) devices will be in the range of 50 billion to 1 trillion [1]. Furthermore, U.S. factories will contain 500 million sensors, where 212 billion sensors will be available in the market [2]. Additionally, approximately 110 million cars will be connected to 5.5 billion sensors, while 1.2 million houses connected with 200 million sensors; 237.1 million wearable body devices are estimated to be available in the market by 2020 [3]. The worldwide IoT market is expected to reach $1.7 trillion in 2020. Additionally, 30.7% of IoT devices will be provided in the healthcare market. The healthcare market for IoTs is estimated to reach $117 billion by 2020 [2] with 507.5 zettabytes of data to be generated by 50 billion connected devices [4].
A large set of IoTs is currently being used in healthcare, which results in a large volume of data. To analyze, store, and pre-process the large variety, volume, and veracity of data, cloud servers are used worldwide. The cloud is currently the only available feasible solution for communications among healthcare IoTs [5]. Cloud computing ease the burden of healthcare IoT devices by removing battery-draining computational tasks [6, 7]. The cloud is the only place for the analysis, filtering, pre-processing, and aggregation of data generated from healthcare IoT devices. However, the cloud has its limitations concerning healthcare IoTs. Owing to the increasing transmission and the determination of these high volumes of data, the reaction time in cloud computing is increasing as well. An upsurge in reaction time results in a higher service latency to end-users. For large data transmissions, more data are transmitted over a network, hence the higher probability of an error occurring. Packet loss and transmission latency are proportional to the amount of data transmitted from IoTs to cloud servers. This causes a poor quality of service (QoS) to end-users. In many time-critical applications of the IoT, cloud-scale processing and storage are not required. Extreme time-bounded selections should be made closer to IoT devices. The healthcare infrastructure requires real-time data for time-sensitive applications. The critical requirements for healthcare IoTs are minimum latency and network bandwidth conservation [8]. The cloud and end-devices are connected via routers and gateways. Therefore, a large number of routers are placed between healthcare IoTs and the cloud. These routers incur computation delays. The larger the distance, the larger is the number of routers used between the source and destination. Data travel a long route from end-devices to a cloud server and consume a high bandwidth.
Motivation
The main motivation for this study is the requirement of minimum latency with good QoS for time-critical healthcare IoT applications. The cloud cannot satisfy all these requirements. As a patient’s physiological state changes with time and to monitor remote patients, rapid decisions and agile responses are required. If network conditions are unpredictable, latency can become more uncertain. Owing to high latency, the patient health data (PHD) are not returned in real time. This render the data meaningless, inadequate, and unreliable. The situation worsens when the processing of cascading-based data is required (such as signal processing of electrocardiogram (ECG) or electroencephalogram (EEG) signals) [9, 10]. The delay of services in healthcare IoTs may vary from millisecond to microsecond [11, 12]. When the data size increases, the round-trip time delay for these healthcare IoT time-sensitive applications increase from milliseconds to seconds and from seconds to minutes [9, 11], thus worsening the real time operations of healthcare IoTs [13, 14]. See Table 1 shows the QoS requirements for medical data.
Table 2 shows the QoS requirements for E-healthcare services.
In January 2014, Cisco proposed a solution to address high latency and network bandwidth consumption between IoTs and the cloud by introducing the concept of fog computing (FC) to the world [17]. FC affords the features of the cloud to the edge of networks [18]. It acts at the edge of networks and. is a type of subcloud [19, 20]. It can be a gateway, router, laptop, or any device that serves as a middleware separating IoTs and the cloud. FC is proposed to reduce the burden of the cloud instead of replacing the cloud. The main goal of FC is to reduce the high latency between IoTs and the cloud. It has proximity to end-devices [21, 22].
Fig 1 shows the transmission of healthcare data in real time to end-users. Here R1, R2, and Rn denote the number of routers used between end-users and cloud servers.
Hitherto, real-world implementations of FC are still rare; FC has primarily been mentioned in literature only [19, 23, 24]. Previous studies regarding FC were related to the standard approach of data communications among IoTs and the cloud; however, for the current scenario, an enhanced intelligent infrastructure is required to serve as a gateway between IoTs and the cloud. This intelligent gateway serves to obtain PHD in real time by reducing the computation, communication, and network latency between healthcare IoTs and cloud servers. Intelligent enhanced FC is a specialized and functional computing model that transfers healthcare data to end-nodes in real time.
Contribution
The significant contributions of this study are as follows:
The FC-based analytical model is proposed to transfer healthcare IoT data in real time to end-users. The model allows fog nodes to determine the optimal functions to be conferred to a reward function. Hence, the fog node can serve as a controller to define its reward function based on the appropriate execution.
A novel hybrid machine learning algorithm is proposed, which uses the fuzzy inference system (FIS) and reinforcement learning (RL) technique based on neural network (NN) evolution strategies to address the problem of high latency between healthcare IoTs, end-users, and cloud servers. The healthcare IoT data is classified into low risk, normal, and high-risk using FIS. Next, the proposed algorithm uses RL and NN evolution strategies for the data packet allocation and selection in fog nodes. The proposed algorithm uses a unique approach and has a simpler data processing convolution and operation that is suitable for computers with parallel core CPUs. Recent research and algorithms in this area lack the hybrid machine learning approach to minimize high latency.
The proposed work reduces the total latency between healthcare IoTs and cloud servers. Here, the total latency (TL) is the sum of computation latency (CPL), communication latency (CL), and network latency (NL) i.e. TL = (CPL)+(CL)+(NL).
Related work
This section presents an in-depth analysis and comparison between existing works and the present work, focusing on high latency, network usage, and bandwidth consumption in IoTs, and cloud and FC.
Wu et al. [25] discussed the requirements of information-centric social networks (ICSN); they applied fog computing security service (FCSS) in ICSN. The ICSN requirements are a deployment scheme, mobility of data, minimum latency, and effective end node communication. The use of fog computing in ICSN results in shifting computational tasks, resources, and intelligence from remote and distance servers to the edge of networks. FC-based content-aware filtering is used to secure the services in ICSN. However, the authors did not discuss the issue of high computational and network latency generated at the fog nodes. Dinh et al. [26] proposed a cost-effective deployment schema for services related to IoTs in fog and cloud networks. Their proposed schema measures the virtual network function (VNF) with the potential to improve the software function chaining (SFC) availability. The author discussed the issues related to hardware and software failure and resource limitations in FC nodes. Li et al. [27] proposed the service popularity-based smart-resources partitioning (SPSRP) method for IoTs and FC; they highlighted the issue of computing and resource efficiency on fog nodes. This proposed work seeks to reduce the delay and response times and fault tolerance in IoTs and fog servers. Similarly, Alam et al. [23] introduced the concept of a basic block offloading mechanism to deploy mobile codes on a geographically distributed fog mobile network in a decentralized manner. The RL technique was used to migrate the blocks in the distributed multi-agent environment. The result showed a reduction in high latency and processing time. Similarly, Kao et al. [28] proposed a new technique called Hermes to minimize latency in mobile computing for time-critical issues. The main function of the technique included the optimization of task assignments for devices that are deprived of resources. This technique was based on the offloading of computational tasks. Nishtala et al. [20] proposed a technique called Hipster to meet the demands of QoS in end-user requirements. The technique involved a combination of heuristic and RL. The combined machine learning effect managed the latency for time-sensitive workloads in cloud computing. However, the authors did not explain the issue of high communication latency in cloud servers. Naas et al. [29] highlighted the problem of high latency for time-critical IoT applications; to resolve it, they proposed a technique called iFogStor. This technique was based on the FC concept. In iFogStor, the issue of data placement was formulated as a generalized assignment problem (GAP). Furthermore, they recommended a method to solve the problem using accurate integer programming and a heuristic approach. This approach requires a more accurate model and architecture for time-sensitive IoT applications. Similarly, Pan et al. [30] discussed various emerging and existing technologies for IoT applications, such as cloudlet, edge-cloud, FC, and mobile-edge computing. They highlighted several existing issues related to IoT, such as high latency and data traffic. An internal study on existing and emerging technologies was conducted by the authors in their survey analysis. However, the research lacks consideration on practical implementation for latency minimization. Cao et al. [31] proposed a machine-learning algorithm to reduce the energy and bandwidth consumption and network usage for mobile devices. They discussed the issue of computational offloading of tasks for multiple users in the cloudlet environment. Next, Brogi et al. [32] proposed a model in the fog environment for IoT to support the QoS deployment infrastructure; they discussed several challenges, such as data distribution, segmentation, and adaptive deployment in IoT and the cloud infrastructure. However, Cao et al. [31] and Brogi et al. [32] did not explain the issues related to the high computational and network latency between IoT and cloud. Mahmud et al. [33] highlighted the problem of high latency and large data transmission in healthcare applications. Therefore, they proposed a cloud-fog based service along with a reference architecture for healthcare applications. An analysis of the obtained results was done with respect to data communication optimization, latency minimization, and reduction in power consumption. The results showed an improvement in cost efficiency, energy consumption, and network delay. Rafique et al. [34] proposed a hybrid bio-inspired algorithm to minimize the response and execution time in the IoT-fog-cloud environment. The hybrid algorithm was a combination of cat swarm and particle swarm optimization. The algorithm was modified to manage the availability of resources and task scheduling in fog nodes. Future work requires the use of the RL technique for resource management in the IoT-fog environment.
To protect and secure the data within the cloud environment, Ahsan et al. [35] proposed a centric FC-based scheme for cloud storage; they discussed several issues related to data security and privacy in cloud computing. The privacy of users’ data is of utmost importance in cloud servers. Therefore, a Xor combination was used to protect the data from unauthorized access and malicious attacks. The results were validated with respect to the data packet processing time. The authors used a new technique based on a hash algorithm to detect the data modification with maximum probability. Waqar et al. [36] proposed a framework to protect and secure the users’ data within the cloud from unauthorized intruders. The framework was based on a dynamic metadata and database schema design. Next, the dynamic metadata was reconstructed for privacy operations and applications. Different cryptographic operations were used to modify the database schema. Scope for future research includes the implementation of the proposed approach using RL techniques. Soleymani et al. [37] proposed a fuzzy-based model to collect correct and authorized information from vehicular ad hoc networks (VANETs). The vehicles in VANET require reliable information. Incorrect information would lead to interruption and system failure. The authors used fuzzy logic to make decisions for constructing rules related to the trust model in VANET. Their proposed work was based on the experience where distributed fog nodes were adopted to check event accuracy in VANETs.
The research analysis and comparison of techniques showed that the research to minimize the total latency (i.e. computational, communication, and network latency) between IoT and the cloud is incomplete. Therefore, a novel approach is required to minimize the high latency for time-sensitive applications in healthcare IoTs. A complete in-depth analysis and comparison of techniques used by different authors in their research are provided in Tables 3 and 4.
Different techniques used by authors in their research are selected as the baseline for comparison and analysis with our proposed approach. The discussed techniques work towards minimizing high latency, network consumption, and RAM consumption between IoTs and the cloud. These existing techniques mostly use conventional FC approaches as middleware gateways for data transmission between IoTs, end-users, and cloud servers. The mentioned techniques play a major role in healthcare IoTs. However, most of the existing works lack real-world implementation of latency minimization between IoTs, fog nodes, and cloud servers. Owing to the above-mentioned reasons, these existing techniques are selected for a comparative analysis with our proposed approach.
In this section, we identify the limitations of the existing techniques in the IoT-fog-cloud environment. In addition, the computation, network and communication latency and network usage are argued to be high and infeasible for healthcare IoTs. The issue of high latency in healthcare IoTs leads to delay in the transmission of PHD to end-users [2, 5]. The analysis of previous research shows that traditional cloud computing approaches and middleware gateways were unable to fulfill the latency demands and QoS requirements of healthcare IoTs [15, 16]. To date, no significant research has been done regarding healthcare IoTs to minimize the round-trip time delay between IoTs, end-users, and the cloud. Therefore, we propose a novel hybrid fuzzy-based RL algorithm employing NN evolution strategies and an analytical model to minimize the high latency. The present study aims to minimize the latency, network usage, and RAM consumption between healthcare IoTs, end-users, and cloud. The proposed algorithm and analytical model meet the QoS requirements for healthcare IoTs.
Materials and methods
Healthcare ECG sensor data were obtained from the online (web source) UCI machine learning repository, which is a center for machine learning and intelligent system [38–42]. In our simulation, the ECG sensor data comprise 14 attributes and 303 instances. However, the original heart disease dataset from the UCI repository comprises 76 attributes. The dataset used in our simulation is a uniformly sampled data. The proposed algorithm was tested on an ECG dataset that includes data from a patient suffering from heart disease owing to high blood pressure, high sugar level, and high cholesterol. The data were recorded continuously. A total of 303 patients’ ECG strips/records were obtained from two leads (one channel). The attribute characteristics of the health dataset are categorical, integer-based, and real. See Table 5 for the data dictionary.
System overview
The Q-learning Markov decision process (MDP) algorithm was used under the constraint to achieve the minimum computation latency, communication latency, and network latency by allocating data packets to different processors of virtual machines. Q-learning MDP is a mathematical framework for modeling decision-making and observations by collecting feedback from past experience in a dynamic environment [43]. The proposed approach requires a Q-learning MDP to account for the dynamic behavior of the IoT-fog-cloud system [23, 43]. The IoT-fog-cloud system was unable to predict the transition probabilities and rewards because of dynamically changing incoming data packet requests at fog nodes. A decision-making process has been established using Q-learning MDP to mitigate the problem of different data packet demands from different users at different time intervals and computational capacities of fog nodes. The Q-learning algorithm solves the MDP with unknown larger rewards and transition functions by exploring and exploiting the different states of the system [23]. Furthermore, it maximizes the total reward for the IoT-fog-cloud system using quality action.
A fuzzy-based RL algorithm was used to monitor PHD in real time. The characteristics of healthcare IoT requires RL to trace the patient background health state in minimum time [21]. The selection of data packets for computation in different fog nodes was performed using RL and a NN [44]. This further balanced the load among the nodes to transfer the data to end-users in minimal time. RL supports the optimum use of available resources by allowing the allocation of distinct data packets to processors without violating QoS barriers for delayed critical workloads [4, 45]. It was designed to obtain feedback from the patient’s previous health record, where the decision for constructing rules was processed by the FIS [23, 37, 44, 46]. The PHD were classified into low, normal, and high risk using fuzzy membership functions and fuzzy rules defined in FIS [47, 48]. Next, RL identified the best outcome of the action to maximize its total reward and the performance of the algorithm in a given time. The proposed algorithm was observed to reduce high latency.
Fig 2 shows the healthcare IoT data transmission model, in which the IoT sends a data packet to fog nodes. Subsequently, the fog nodes directly send the data packet to end-users. A master fog controller controls the fog node’s data transmission and selection and communicates further to a cloud server.
The process in the proposed model allows fog nodes to select appropriate data transmitted from IoT devices. Next, PHD is computed and transferred to other fog nodes and end-users in real time. This process is designed to reduce the high latency, i.e., reduces the total latency between IoTs and end-users. Distributed intelligent decision-making is required for the distribution of data packets to other fog nodes for computation. This distribution of data packets is associated with the requirement of data in minimal required time by end-nodes. The decision of data packet distribution considers the communication delay, prolonged computation delay, and network delay. A delay occurs between nodes owing to the transmission of a large number of data packets over a network. Crucial decisions include (i) which data packets for computation should be allocated to fog nodes to be sent in real time, (ii) How many data packets should be uploaded and migrated, and (iii) Scaling of data packets to fog nodes. It is noteworthy that the existing schemes emphasize primarily load offset and coordinated migration in a fog environment [19]. Studies to minimize the total latency among IoTs, end-users, and cloud servers using intelligent FC based on a hybrid machine learning approach have not been conducted. Generally, most previous studies do not convey the practical aspects of fog networks [19, 49]. The proposed new algorithm prepares the data allocation issue in the form of an MDP and is accountable to the change in system from the context of fog nodes. This problem allows fog nodes to move their data packets after allocation and computation to other fog nodes, which further transfer them to end-users. The proposed fuzzy-based Q-learning model in fog networks differs from existing approaches based on two main aspects. First, the dynamic environment is based on the end-users’ request for time-sensitive data packets from different distributed fog nodes. The interhop gap among neighboring fog nodes results in a change in the decision-making process for actions that are then selected to minimize service latency. Second, the network traffic control in a fog network refers to efficiency in data packet distribution to a fraction of fog nodes such that users can more easily access data in real time. It is a type of dynamic data packet allocation schema where the fog node allocates only data that are time-sensitive or requested by users. In our proposed method, fog nodes are defined as a server that can perform communication while exhibiting processing and computing capacity.
Analytical model
System model
Fig 3 shows the healthcare IoT system model for the FC environment. The data transmitted from healthcare IoT devices are classified into low risk, normal, and high risk by applying a FIS classification process. PHD are allocated through RL in various virtual machines in fog servers. The time-sensitive data are selected using an NN and sent to end-users within the minimum required time. In virtualization, fog nodes are used in the distribution and allocation of data packets among other nodes and end-users. End nodes are linked to fog nodes, where information retrieval can be sent.
A master fog node controller that contains the topology information of data packet allocation and distribution is used. Nodes are connected through a network topology and all the nodes are further connected to the master fog node. This study investigates a progressive data packet allocation approach using fog computation in the machine learning environment. The nodes can transfer data packets to other nodes to minimize latency and network traffic. Here, the CPU comprises data packets in a queue, which can be used as a good traffic index on nodes and affects the average response time. Each fog node can gather information, make decisions, serve the end nodes, and provide data on assembling traffic information and queue position. The master fog creates a network table by considering the information distributed from other nodes. The master fog node sends requests to determine whether the current node should move the required data. If so, data will be moved to the neighboring node, where selection is performed based on time and requisite data. The main objective of this study is to select time-sensitive data while reducing latency and network traffic.
Problem formulation
To accomplish the requisite execution, the suggested problem of latency minimization in healthcare IoTs and cloud was developed as an MDP, for which an algorithm with a performance guarantee [22, 23, 27] is proposed. The MDP comprises a fog node in the form of a selection agent that regularly inspects the instant conditions of the controlled system, selects between those who have permission in the state (a ∈ Ai(s)), and then detects the progression in a different state s′ and reward r, which will transform its subsequent selections. In the MDP, the agent selects an action as the work of states. Therefore, the new state and reward transition probability distribution will be observed. In our system, the master fog node selects an action as a function of the current state and considers the reward shown in the following states and all nodes. Our MDP is characterized by a 4-tuple 〈Si, Ai, Pi, Ri〉, where Si={s=(nl,dlp,Q)} is the state space, nl ∈ N(1 ≤ nl ≤ N) is the node that contains the data packets for allocation as requested by the end-users, dlp∈N(1≤dlp≤DmaxLP) is the number of data packets to be allocated per unit time, Q = {Q1, − − − − −, QN} | Qi ∈{0, 1, − − − − −, Qi,max}} is the number of data packets and currently remaining in the queue of the fog node. Additionally,Ai={a=(nf,dfp)} is the action space, where nf ∈ N(1 ≤ nf ≤ N, nf ≠ nl) is defined as the neighboring node within the fog network that is being allocated with data packets sent by node nl.
dfp∈N(1≤dfp≤DmaxLP) is the number of data packets sent to nf, which is a neighboring fog node.
Let Ai(s) ∈ Ai be a group of actions that can be performed on state s. Ai(s) is defined such that node nl can only move the data packet to the second node and to the user with the same or a smaller number of data packets currently required. Based on the action a, the total count of data packets to be locally processed (dfl) is decided with respect to the accessible queue space of node nl.
Pi: Si × Ai × Si →[0, 1] is the transition probability distribution Pi(s′, a) of a new state s′ from a given state s when an action a is performed.
Ri: Si × Ai →Ri is the reward when the system is in state s and action a is performed. The essential objective of the system is to perform a peerless data packet allocation operation on each node to maximize the utility while reducing latency and data packet allocation probability. Therefore, the determined system characterizes the instant reward function Ri(s, a) given action a at state s as follows:
The instant utility is computed as
Communication latency
The round-trip times required by a data packet from an end-user node (wearable IoT device) to a fog node and from a fog node back to an end-user node (wearable IoT device) are determined, as follows:
Here, dlp is the number of data packets sent by ne to nf and ne, dfp the number of data packets sent by nf to ne and nl, dfl the number of data packets sent by nl to ne and nf, DPS the size of data packets, vne,nf the IoT device transmission service rate from ne to nf, vnf,ne the fog transmission service rate from nf to ne, vne,nl the transmission service rate from ne to nl, vnl,ne the fog transmission service rate from nl to ne, vnl,nf the transmission service rate from nl to nf, vnf,nl the transmission service rate from nf to nl, Bew,Bfw, and Blw the bandwidths per a node ne, nf and nl, gne,nf≜β1dne,nf−β2, gnf,ne≜β3dnf,ne−β4, gnl,ne≜β5dnl,ne−β6, gne,nl≜β7dne,nl−β8, gnl,nf≜β9dnl,nf−β10, and gnf,nl≜β11dnf,nl−β12 the channel gains for vne,nf, vnf,ne, vnl,ne, vne,nl, vnl,nf and vnf,nl, dne,nf the distance between nodes ne and nf, dnl,ne the distance between nodes nl and ne, dnl,nf the distance between nodes nl and nf, Ptxne, Ptxnf, and Ptxnl the transmission powers of nodes ne, nf and nl, N0e the noise power density for transmission service rate from ne to nf and nl, N0f the noise power density for transmission service rate from nf to ne and nl, N0l the noise power density for transmission service rate from nl to ne and nf, β1, β3, β5, β7, β9 and β11 denotes the path loss constant, and β2, β4, β6, β8, β10 and β12 denotes the path loss exponent, respectively.
Network latency
By assuming the same latency for every hop delay, the network latency depends on the total packets sent from end-user node ne to fog node nl, nl to fog node nf, and from nf to ne; the network latency is expressed as
Computation latency
By assuming a query system and neglecting packet loss, with the data packet arrival rate and service rate for the fog node, the computation latency(waiting time and service time) can be expressed as
The data packet allocation probability O(s, a) is calculated as
The data traffic rate is to be sent through a one-hop transmission path from fog nodes nl and nf to an end-user node ne. It is important to certify the QoS (latency requirement) for end-users. Owing to large data transmission and high data traffic, end-user experience several delays including computation latency (delay in queues on nodes), communication latency, and network latency. The purpose of the proposed method is to reduce latency, with the transition probability Pi and reward Ri determined before the execution of the system. In each state, the optimum action is defined as a series that yields the maximum long-term reward, which is the disclosure sum of the expected recent rewards of all future decisions regarding the state-action that begins with the present state. In the future, the instant reward obtained in k′more time steps is worth γik′−1 times, where γi is labeled as a discount factor (0 < γi < 1). The highest value function is determined, which satisfies the Bellman optimality equation:
Mathematical framework for latency minimization
In maximum events, the system cannot accurately predict probability Pi and reward Ri because the system can cause variations in those parameters. To discourse this limitation, RL is suggested. In RL, the loss of confidential data is solved by observing background details [44]. The canonical decision-making algorithm has limited functionalities in RL owing to its hypothesis of an ideal model and its considerable estimation value [21]. Q-learning is a canonical model-free algorithm [44] that is frequently applied to the acquisition of the highest state-action method for any MDP. For the proposed system, the learning master fog node acts as a controller that continuously detects the present state s with an action a, followed by a transition. Subsequently, it detects the different state s′ and the reward r. With these detections, it manages and renews its projections of the Q-function such that the following is obtained:
One application of the ∊-greedy algorithm is when the fraction of moves is incremented, the entire action is determined to be a converse immeasurable fraction of the total duration, thus certifying that Q(s, a) is the optimum value [21]. The estimated reward function, selected by the proposed approach, is calculated using Eq (1). After defining its three components, the next state s′ is obtained. Whereas the neighboring queue of the state is an arbitrary unit, the adjacent fog node has the function of sending data packets for allocation to other fog nodes. After the arrival of the data packet, the data size is determined at the fog node.
The demand for localized and location-based information services from patients/end-users is high. End-users are unable to retrieve time-critical localized data from cloud servers; thus, the FC approach is used [50, 51]. Depending upon the user requirement, fog nodes deploy the local computing facilities at the user end. Fog nodes deliver stored cloud data to mobile users with fast local connections [52]. Fog devices can be a hardware router, switches, IP video cameras, etc. A fog server can be a virtualized computing system and a lightweight cloud server.
A mathematical framework is presented to investigate the latency-delay tradeoff by process allocation in the FC environment. FC can provide a low latency response for time-sensitive applications. Low latency is required for the i-th service distribution and the completion phase. Communication latency depends on multiple channel factors (medium transmission capacity; connection between resources and interface). Computing latency is managed by the fog node itself. In our proposed method, RL is used for a long-term period; RL uses progressive strategies to allocate real-time data packets between fog servers to reduce the total latency. It has been observed that total latency includes communication, computing, and network latency. To adapt to different networking environments, we considered data packets in the form of a random and independent packet to be propagated over a communication channel between IoTs and fog servers. Let (sid,cid,τid) denote a three-dimensional characteristic vector of the i-th data packet, where 〈sid,cid,τid〉 is the packet size, complexity, and latency limit of the data packet, in combination. Further, fjCPU and bjs indicate the frequency of the CPU in Hz and the current storage size of the j-th fog server, respectively. Consider that the i-th data packet ascribes to the j-th fog server; then the latency of the i-th data packet at the time of allocation to the fog servers is expressed by
Long-term optimization is achieved by selecting a fog server to assign the required data packet for allocation. Once data computation is complete at the fog server, the data are sent to the end-user, which further minimizes the total latency.
To express this problem mathematically, let yij denote the case when the i-th data packet is assigned to the j-th fog server. The latency minimization function at time slot t is characterized by
To fully process the uploaded data packet, the computation latency of the system becomes maximal between the distributed fog servers. The decision is made using the greedy method, which reduces the system latency when data packets are uploaded.
Fuzzy-based RL algorithm for real-time PHD transmission
The proposed algorithm is divided into two-sub algorithms: Algorithm 1 and 2.
Algorithm 1: Healthcare data is classified using an (FIS). Here, the tuples are created and merged in a fuzzy system that is used as input to the FIS. Fuzzy sets are created for the final values, followed by the FIS for PHD classification.
Algorithm1 Patient Health Data (PHD) classification using FIS.
Algorithm Symbol Notations:
fG: Fog gateway for allocation of the data packet
μ1: Fuzzy Inference System membership function
RTA: Real-Time Analyzer
Pid: Patient id
1: (Fuzzy system) the system is created with inputs and their member functions μ1
2: With the function, μ1(HeartRate1), μ1(ECG1), get the condition of health as μ1 (normal) or μ1(low risk) or μ1(high risk)
3: IF (Health Condition = μ1 (high risk))
THEN get geo-location
send
A notification to fG using SPARK as RTA
4: ELSE IF (Health Condition = μ1(low risk)
THEN the Pid is sent to fG
5: END
In our proposed method, the training environment is a system comprising fog servers. In a model with RL, an action selection function exists (i.e., data packet selection and data packet allocation to fog server in real time); the function selects actions stationed on the state of the system.
Values are available to define and express the system state. These values are the (1) demand (complexity and size of data packets), (2) remaining data packets in fog storage, (3) time consumed from the last instant to upload the data packet to the present instant, and (4) series of requirements from the final data packet. When the data packet is uploaded for allocation to the fog server, we need to measure the time duration required by the server to complete the computation of the previous remaining data packets, e.g., the computation latency of the servers, and submit the value in the form of a [K × 1] vector. Subsequently, we determine the duration of time that the server will allocate if the arrival data packet is accredited. The value is saved in an additional vector of similar size [K × 1]. Combining the two abovementioned vectors, we obtain a [2K × 1] vector that exemplifies the state of the system near a given time. We quantify the computational latency, in microseconds, for fog servers to allocate data and send data packets. Data packets require minimal number of megacycles for its allocation; thereby, a deviation in expected latency occurs between the servers. Based on the latency in allocation, processing, and transmission of data packets, we create the state of the system in a vector form. The NN is selected as the action selection function in an RL model. The state is the input of the NN system. The size of the state is [2K × 1], the input layer of the NN contains 2K nodes Z(i), i = {1, 2……K}, and the nodes are connected to every other node in the hidden layer. In the hidden layer, M nodes exist, denoted as Hj, j = = {1, 2……M}. Consequently, a [M × K] network relationship exists between the input and the hidden layer. Every packet gains a weight, with the ability to store all the weights of the packets and a matrix Wl(1) is present. Weight Wi,jl(1) represents the relation between Z(i) and Hj in row i and column j. The value of node Hj in the hidden layer is the gross summation of all the products of weights and inputs.
The total count of nodes in the hidden layer can induce the training process. Hidden layer nodes are attached to the NN output layer, called the softmax layer [53]. The capacity of the output layer is [K × 1]. A matrix W(2) whose capacity is [M × K] stores the total weight of the network combination between the two layers. In the end layer, the node T^(f) value is calculated as
After calculating the values of all the nodes, the time-sensitive PHD are transferred. Here, a fog server fog(i) is selected to transfer the time-sensitive PHD, where i = 1, 2 − − − − K. Its probability is given by
To assign the uploaded data packet, the server with the highest probability is selected.
Eq 23 is derived using the softmax function [54]. The latter calculates the probability distribution for k real numbers and normalizes it into k probabilities, which are directly proportional to exponential functions of the input real numbers. Eq 23 is calculated using the softmax function formula, which is defined as σ(b)j=ebjΣf=1kebf for j = 1, − − − −, k, and b(b1, − − − − − bk). The exponential function is applied to each element bj of the input vector b. Next, normalization is performed to guarantee that the sum of the components of the output vector σ(b) is equal to 1. The softmax function is widely used in NN and RL. In RL, the softmax function is used to convert node values into probabilities [54].
Fig 4 shows the structures of the hidden and input layers in the NN of our proposed model. The NN is trained by restoring the weight matrices, e.g., W(1) and W(2), to exaggerate the response from the background details. In some RL-specific applications, backpropagation is performed to update the weight matrices [21, 55, 56]. However, this method is inefficient for the floating values of latency. Therefore, we selected a rival of the backpropagation method for NNs [55, 57, 58], which is called the NN evolution algorithm.
Progression approach for the evolution
To optimize and train the machine learning model, a function is defined to assess the model performance in a problem established over an operational function. An RL model can determine the problems of data packet selection and allocation to fog servers in real time. Our aim is to select an action to reduce the long-term latency of the structural system, although RL can train the system to maximize the reward [59]. Here, the reward is inversely proportional to the system latency. After selecting an action a(t), the reward from the system is defined as
Here, lij(t) is the latency produced by action a(t). Action a(t) is performed to assign the approaching i-th data packet to the j-th fog server. It is examined in a certain manner when t → ∞, l(t) → ∞ along with Rewardi → 0. Coordination by the latency minimization function (fΔ) in Eq (20), reduces the long-term latency of the system, which can be moderated by reducing the latency over the transition of K successive data packets for amplifying the equalization of rewards on K new actions. Hence, the reward is defined as
To upgrade the RL model for consecutive rewards, we restore the NN to increase the capacity of the model in selecting an action each for data packet selection and data packet allocation in the fog server. The most popular current algorithm in machine learning for updating an NN is backpropagation [55, 57, 60], which is feasible if the reward is either 0 or 1. Hence, backpropagation is no longer applicable considering our long-term reward. Neuroevolution (NE), i.e., neural network evolution, is used for training NNs [44, 55]. An NN is now assigned to each iteration; from the NN, a new generation is produced. This generation is a derivation of the NN [44, 57]. Children selection is based on a higher reward to renew the NN. To update the NN, evolution strategies are applied. It is now an accepted and recognized algorithm to apply to the NE method. [44, 55, 57].
Algorithm 2 illustrates the mechanism for data packet allocation and selection in real time. Algorithm 2 uses the greedy and NN approaches, where decisions are made by applying the greedy technique to minimize the latency of the schema at the time of data packet allocation. The NN is updated by evolution strategies in an RL environment [23, 44, 55]. For every repetition, M children of the NN are formed by the summation of Gaussian noise to each weight in the network. Every child in the NN performs a role each for data packet allocation and data packet selection in an RL model with K data packets and receive an average reward (Mean_rewardi) over K actions.
Algorithm 2 RL with the greedy method and evolution strategies.
1: Input learning rate (αi) and discount factor (γi), exploration policy (∈), service rate (vi), data packet arrival rate (λi), and distance vector (Dv), Parent NN with a weight matrix W(i), No. of children M. i = 1, 2
2: Output Data allocation table (Q)and Parent NN with maximum performance.
3: Set Q(s, a) = 0(∀s ∈ Si)(∀a ∈ Ai(a)), iter ≔ 0, and s ≔ (1, 1{(Q1 − − − − − − − QN)| Qi = 0})
4: While (iter ≤ maximum iteration) do
5: Select a ∈ Ai(a) applying ∊ - greedy algorithm
6: Allocate the data packets conferring to action a and examine the next state s′ and reward r.
7: Q(s,a)←(1−αi)Q(s,a)+αi[Ri(s,a)+γimaxa′∈Ais′Q(s′,a′)]
8: s ← s′
9: iter ← iter + 1
10: For iteration in a predetermined range do
11: For H in range M do
12: child(H) = Parent NN + random noise (N0), [W(i)(H) = W(i) + noise]
13: Evaluate
14: Calculate Mean_rewardi
15: Gaini(H)=Rewardi(H)−Mean_rewardi H = 1, − − − − − −, M
16: Parent NN → Parent NN + αi×∑H=1MGaini(H)×child(H)W(i)=αi×∑Gaini(H)×W(i)(H)
17: Evaluate Parent NN
18: END
Subsequently, the maximal performing parent NN and data allocation table (Q) are obtained.
The method for this suggested Q-learning algorithm is conferred in algorithm 2. The algorithm explores the field that presents the optimum reward for the data packet selection and allocation problems in an RL model.
Fig 5 illustrates the proposed algorithm flow for healthcare IoT data packet communication in real time using FC. Different procedural steps are shown for algorithms 1 and 2. The flow chart provides an insight into the proposed algorithm.
Results and discussion
Performance analysis and evaluation
In this section, the execution of the proposed analytical model with the proposed machine learning algorithm is evaluated and analyzed. A numerical test was conducted to verify the proposed hybrid machine learning algorithm and fog-based model. Predictive analysis using a support vector machine (SVM) was performed on PHD to examine the robustness of the performance measures. The key performance measures used to establish the validity and utility of our proposed algorithm are accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
Simulation overview
The performance of the FC model that incorporates the proposed algorithm is analyzed through simulation and experiments. The baseline for this simulation is minimum latency, minimum network usage, and minimum RAM consumption in cloud and FC environments. To simulate the FC-based analytical model, we used iFogSim [14] as an open-source software tool and the Python-based Spyder editor tool.
Performance analysis
This subsection discusses the performances of the analytical model and the algorithms in terms of latency, network usage, and RAM consumption. The complete function of algorithm 1 is shown in Fig 6. A fuzzy control system is created using algorithm 1 in the Python editor tool. Algorithm 1 is used to classify ECG sensor data. We used the skfuzzy API to model the fuzzy system. Subsequently, to simulate algorithm 1, a control system is created. The control system defines the inputs, which is called the compute method. Once the simulation is completed, the results can be visualized. The data are classified using an FIS and a linear SVM. Using RL and NN evolutions strategies, algorithm 2 selects high-risk data (i.e., data with high ECG value) for data packet allocation and selection in various distributed fog servers.
Fig 6 shows the generated healthcare data. In the FIS, fuzzy sets are created with a fuzzy range of values. Next, we the output results are classified as low risk, normal, and high-risk health data based on the fuzzy rules and with member functions μ1 (HeartRate1) and μ1 (ECG1) to obtain the condition of health as μ1 (normal), μ1 (low risk), or μ1 (high-risk).
Fig 7 shows the low risk, normal, and high-risk healthcare ECG sensor data generated by algorithm 1 (as shown in Fig 6). The green line shows the high-risk ECG value with respect to the membership functions, whereas the red and blue lines show the normal and low-risk ECG values. Linguistic variables and fuzzy sets are created in the FIS. Membership functions are used as the ECG input and range. The next step is to regulate the extent to which input variables belong to the membership functions.
In Fig 8, the data are further classified to the highest varied two principal component analysis (PCA) values using the linear SVM to display not-under-risk and under-risk data.
Here, red shows the under-risk heart disease data, and green shows the not-under-risk data. The linear support vector classification (SVC) values are split with two PCA values. The dataset is divided into 70% and 30% for training and testing, respectively. Subsequently, the training and test data were cross validated. To verify the accuracy of the fuzzy classified healthcare data, we used the linear SVM [61]. Although the previous classification accuracy of the used dataset is 79.4333%, in our case, the linear SVC values with the split are 0.8765213110411, i.e., 87% for healthcare data; the linear SVC score without a split is 0.8354674540625, i.e., 83%. The sensitivity of the model for the dataset using the SVM is 82.61%. The specificity of the model with healthcare data using the SVM is 81.63%. Similarly, the PPV for our model is 66.41% and the NPV for our model using the SVM in the healthcare dataset is 79.47%. It is necessary to remove the missing values and outliers and then fill the values with a mean data value. The missing values are removed using a Kalman filter. Fig 8 shows the linear SVC values with a split. The two PCA values are considered to show the highest variation in the classified health data.
Fig 9 shows the GUI built on the iFogSim simulator. The simulation was performed to evaluate the latency, network consumption, and RAM usage for healthcare IoTs with respect to data transmission and data computation in fog nodes and cloud servers. The iFogSim simulator is based on the CloudSim simulator; it is used to simulate fog nodes and the healthcare IoT framework. Using the GUI in the simulator, we created physical elements such as fog devices, sensors, tuples, and connected links [14]. The physical topologies were built using the GUI and programmed using Java APIs. The object attributes were defined using the GUI in the topology. The topologies were stored and restored by modifying the topology from the JSON file format. Similar to the cloud, in iFogSim, IoTs and servers communicate with each other through message passaging and events. iFogSim enables the execution of multiple applications and supports the migration of application modules. The simulation performance was assessed based on various topology sizes. We used different libraries in iFogSim to execute the simulation. The simulation was conducted on an Intel® i-7 core processor 4.30 GHz with 8 GB of RAM. The simulation involves a fog device to exchange data packets between the system entities. The simulation was performed for 3 h. The results demonstrated how different workloads and data allocation affected the latency. The fog device was connected to IoTs through Wi-Fi. To test the proposed algorithm performance in the iFogSim simulator, we varied the topology sizes by varying the IoT devices and maintaining the number of fog devices. The physical topology in iFogSim includes fog devices, ECG sensors, and cloud servers. Five configurations of the physical topology are simulated as config.1, config.2, config.3, config.4, and config.5. The new proposed algorithm was then programmed into the available libraries of the iFogSim simulator. This was performed to analyze the performance of the proposed algorithm using FC. Tables 6–9 show the descriptions of the fog devices, edge module, ECG sensor configuration, and network link. The data size for the PHD was defined in terms of megabytes.
In Figs 10–14 below, config.1, config.2, config.3, config.4, and config.5 show different physical topology configurations for FC and cloud computing in an IoT infrastructure.
Fig 10 shows a comparison of communication latency between FC and cloud computing under different topology configurations. In this simulation, an ECG sensor first generates a tuple (link) and sends it to the associated fog nodes, routers, and gateways. Once the tuple reaches the fog node, the fog server processes the incoming packet and sends the packet to another fog node. The fog node further sends the data packet to end-users.
The number of hop counts decreases when the data packets are transmitted between IoTs and fog computing servers. The algorithm implementation in iFogSim minimizes the network latency by distributing the fog nodes at the network edges. Meanwhile, the network latency increases when large data transmission occurs between IoTs and cloud servers.
Fig 12 shows the difference in computation latency between FC and cloud computing.
To measure the heap allocation, a massive heap profiler was used during the simulation of different topology sizes and input workloads. Here, the heap allocation did not escalate sufficiently with the increases in workload and physical topology configuration and size. The simulation scales with the minimum memory overhead despite an increase in the data transmission. Fig 13 shows the RAM consumption for data packet allocation and processing in fog nodes and cloud servers. The data packets are allocated at the edge of networks, thereby reducing the network usage. RAM is used with the input workload to quantify the heap allocation while simulations of different topology sizes and input workloads are performed.
Fig 14 shows the network usage by the ECG sensor device for data packet transmission in different physical topology configurations. Examining the fog devices, the network management degraded significantly as the fog nodes are distributed over a region. The results can also be interpreted as a fog-based scalable demonstration. Whereas in the case of cloud-based executions, the uncontrolled growth of networks results in network congestion and performance degradation. A fog-based deployment can be adopted for better efficiency and performance.
Discussion
In our simulation, the average values of communication latency, network latency, and computation latency for the healthcare IoT infrastructure using FC in different physical topology configurations are 75.934, 69.86, and 270.896 ms, respectively. Furthermore, the average values of RAM consumption and network usage are minimized to 20.078 MB and 86.776 KB, respectively. Our proposed algorithm shows a minimization of latency percentage by 97–98% over other existing state-of-the-art methods. The results generated by simulating our proposed model demonstrated a better performance and efficiency in latency minimization compared with other known methods such as that of Hermes [28], which demonstrated an improvement in latency minimization by 16%; and Hipster [20], which demonstrated an 80–90% improvement in QoS for web searching. Another method, iFogStor [29], reduces the latency by more than 86% compared with cloud computing. The simulation outputs of our experiment were used to verify the execution gain of the prospective method. Additionally, the algorithm has low computational complexity. The results demonstrated that the RL method is compatible with the FC system. In this study, we modeled FC using RL and an NN. Some important parameters used in the simulation are summarized in Tables 6–9. The proposed work significantly reduced computational latency, communication latency, and network latency, as well as network usage and RAM consumption for healthcare IoTs. The experimental results demonstrated an enhanced execution of the proposed approach for latency minimization using FC.
Conclusion
Healthcare IoT devices generate a large volume of data. Processing this leads to delay in services provided to end-users in an IoT-cloud environment. Traditional cloud services are unable to fulfill the latency demands of healthcare IoTs. Therefore, to minimize the high latency between healthcare IoTs, end-users, and cloud servers, we presented a FC-based analytical model. This model consists of fog nodes, fog servers, and the master fog controller, where end-users and patients can directly communicate to fog nodes in a single hop count. Then, we proposed a novel hybrid fuzzy-based RL algorithm employing NN evolutions strategies. The proposed algorithm was used for healthcare IoT data packet allocation and selection in a FC environment. The healthcare IoT data are classified using FIS and the linear SVM. The data packet allocation and selection are implemented using RL and NN evolution strategies in fog nodes. The issue of high latency was investigated using the following parameters: communication latency (ms), computation latency (ms), network latency (ms), network usage (KB), and RAM consumption (MB). The simulation of the proposed algorithm showed better results compared to those of existing techniques. Therefore, the proposed approach was concluded to be an optimal method, which indicates its applicability in healthcare IoTs. The proposed algorithm significantly reduces the high latency between healthcare IoTs and cloud servers. In the future, we plan to research the reliability and security of the healthcare IoT data using different cryptographic operations and techniques.
Supporting information
S1 File [xls]
Input healthcare ECG data.
Zdroje
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- Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study
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- The trajectory of patterns of light and sedentary physical activity among females, ages 14-23
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- Measuring the complexity of directed graphs: A polynomial-based approach
- Estimation of maize evapotraspiration under drought stress - A case study of Huaibei Plain, China
- Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
- Developmental conservation of microRNA gene localization at the nuclear periphery
- Exploring critical factors of the perceived usefulness of blended learning for higher education students
- Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts
- Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats
- Direct transport vs secondary transfer to level I trauma centers in a French exclusive trauma system: Impact on mortality and determinants of triage on road-traffic victims
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- Bacterial communities in the rhizosphere, phyllosphere and endosphere of tomato plants
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- Does aneurysm side influence the infarction side and patients´ outcome after subarachnoid hemorrhage?
- Raising the bar: Recovery ambition for species at risk in Canada and the US
- Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
- Foraging strategies are maintained despite workforce reduction: A multidisciplinary survey on the pollen collected by a social pollinator
- Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017
- Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
- Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice
- Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques
- Variation in the LRR region of Pi54 protein alters its interaction with the AvrPi54 protein revealed by in silico analysis
- Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
- Statistical determination of synergy based on Bliss definition of drugs independence
- The association between sleep problems and academic performance in primary school-aged children: Findings from a Norwegian longitudinal population-based study
- Estimating the national cost burden of in-hospital needlestick injuries among healthcare workers in Japan
- Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data
- Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method
- Integrative proteomic and phosphoproteomic profiling of prostate cell lines
- Treatment paths for localised prostate cancer in Italy: The results of a multidisciplinary, observational, prospective study (Pros-IT CNR)
- Why are undergraduate emerging adults anxious and avoidant in their romantic relationships? The role of family relationships
- Barriers to implementation of emergency obstetric and neonatal care in rural Pakistan
- Testosterone supplementation improves insulin responsiveness in HFD fed male T2DM mice and potentiates insulin signaling in the skeletal muscle and C2C12 myocyte cell line
- Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma
- Factors influencing bird-building collisions in the downtown area of a major North American city
- Collembola laterally move biochar particles
- Decreased retinal thickness in patients with Alzheimer’s disease is correlated with disease severity
- Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume
- Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease
- Boundary violations and adolescent drinking: Observational evidence that symbolic boundaries moderate social influence
- Inadequate conflict of interest policies at most French teaching hospitals: A survey and website analysis
- A new resolution function to evaluate tree shape statistics
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- Patients undergoing surgery for lumbar spinal stenosis experience unique courses of pain and disability: A group-based trajectory analysis
- Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey
- The factors associated with being left-behind children in China: Multilevel analysis with nationally representative data
- High heat tolerance in plants from the Andean highlands: Implications for paramos in a warmer world
- Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings
- Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
- Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea
- Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model
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- Psychology of personal data donation
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- Visual detection of time-varying signals: Opposing biases and their timescales
- Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
- Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
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- Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
- Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
- Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
- Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
- Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
- Sex differences in the treatment and outcome of emergency general surgery
- Comorbidities and costs in HIV patients: A retrospective claims database analysis in Germany
- Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
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- A comparison of body composition assessment methods in climbers: Which is better?
- Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
- Elucidating genetic variability and population structure in Venturia inaequalis associated with apple scab diseaseusing SSR markers
- Clustering via hypergraph modularity
- Indomethacin enhances anti-tumor efficacy of a MUC1 peptide vaccine against breast cancer in MUC1 transgenic mice
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- Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
- Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy
- Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
- Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
- Gender essentialism in transgender and cisgender children
- Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
- Being there: A scoping review of grief support training in medical education
- Does the psychological profile influence the position of promising young futsal players?
- Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
- Olfactory screening of Parkinson’s Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin’ Sticks 12-identification test
- Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia
- Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
- Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia
- Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
- Resilience assessment of Puerto Rico’s coral reefs to inform reef management
- Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
- Implementation and effectiveness of non-specialist mediated interventions for children with Autism Spectrum Disorder: A systematic review and meta-analysis
- A tailored cognitive behavioral program for juvenile justice-referred females at risk of substance use and delinquency: A pilot quasi-experimental trial
- Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation
- Machine learning algorithm validation with a limited sample size
- The magnitude of suicidal ideation, attempts and associated factors of HIV positive youth attending ART follow ups at St. Paul’s hospital Millennium Medical College and St. Peter’s specialized hospital, Addis Ababa, Ethiopia, 2018
- The nonlinear effect of financial and fiscal policies on poverty alleviation in China—An empirical analysis of Chinese 382 impoverished counties with PSTR models
- Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
- Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
- An expansin-like protein expands forage cell walls and synergistically increases hydrolysis, digestibility and fermentation of livestock feeds by fibrolytic enzymes
- Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps
- Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy
- Live observation of the oviposition process in Daphnia magna
- On the accuracy of displacement-based wave intensity analysis: Effect of vessel wall viscoelasticity and nonlinearity
- Nodosilinea signiensis sp. nov. (Leptolyngbyaceae, Synechococcales), a new terrestrial cyanobacterium isolated from mats collected on Signy Island, South Orkney Islands, Antarctica
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- Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
- Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
- Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
- Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism
- Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer
- Effect of mechanochemical activation of natural phosphorite structure as well as phosphorus solubility
- Automated content analysis across six languages
- A deep learning reconstruction framework for X-ray computed tomography with incomplete data
- Integrating interconception care in preventive child health care services: The Healthy Pregnancy 4 All program
- The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
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- Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
- Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement
- Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
- Association between cerebral atrophy and osteoporotic vertebral compression fractures
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- Gene expression based survival prediction for cancer patients—A topic modeling approach
- Understanding allergic multimorbidity within the non-eosinophilic interactome
- The association between psychological distress and angina pectoris: A population-based study
- Comparative analysis on Facebook post interaction using DNN, ELM and LSTM
- Cerebellum-mediated trainability of eye and head movements for dynamic gazing
- Psychological and physiological effects of applying self-control to the mobile phone
- Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy
- Genome-wide SNP analyses reveal population structure of Portunus pelagicus along Vietnam coastline
- Modulating transcription through development of semi-synthetic yeast core promoters
- Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications
- Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data
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- Validation of the group tasks uncertainty model (MITAG) in a German sample
- Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
- Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging
- In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
- Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
- Characterization of the placental transcriptome through mid to late gestation in the mare
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- Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
- Predictors of never having a mammogram among Chinese, Vietnamese, and Korean immigrant women in the U.S.
- The impact of hepatic steatosis on portal hypertension
- How do and could clinical guidelines support patient-centred care for women: Content analysis of guidelines
- Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
- School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
- Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
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- ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
- Nurses’ and patients’ experiences and preferences of the ankle-brachial pressure index and multi-site photoplethysmography for the diagnosis of peripheral arterial disease: A qualitative study
- Cluster tendency assessment in neuronal spike data
- Voluntary medical male circumcision for HIV prevention among adolescents in Kenya: Unintended consequences of pursuing service-delivery targets
- Primary care in five European countries: A citizens’ perspective on the quality of care for children
- High Order Profile Expansion to tackle the new user problem on recommender systems
- Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)
- Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar
- Methods for the identification of farm escapees in feral mink (Neovison vison) populations
- Transcriptional analysis of amino acid, metal ion, vitamin and carbohydrate uptake in butanol-producing Clostridium beijerinckii NRRL B-598
- Long-term vancomycin use had low risk of ototoxicity
- Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
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- Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
- Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated ‘in vivo’ by surgical procedure with interest in liver transplantation
- Molecular characteristics of segment 5, a unique fragment encoding two partially overlapping ORFs in the genome of rice black-streaked dwarf virus
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- GLADS: A gel-less approach for detection of STMS markers in wheat and rice
- Anterior tooth-use behaviors among early modern humans and Neandertals
- Incidence patterns of orofacial clefts in purebred dogs
- Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice
- Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
- Predicting atrial fibrillation in primary care using machine learning
- M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
- A developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
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- Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera
- Population genetic analysis of 36 Y-chromosomal STRs yields comprehensive insights into the forensic features and phylogenetic relationship of Chinese Tai-Kadai-speaking Bouyei
- Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries
- An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
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- Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
- A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
- Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells
- Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
- The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
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- Does age influence the quality of life in children with atopic dermatitis?
- Questioning the lasting effect of galvanic vestibular stimulation on postural control
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- Occurrence and multilocus genotyping of Giardia duodenalis from post-weaned dairy calves in Sichuan province, China
- Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
- Gender disparities in scientific production: A nationwide assessment among physicians in Peru
- Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
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- Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
- Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
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- Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
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- Institutional differences in USMLE Step 1 and 2 CK performance: Cross-sectional study of 89 US allopathic medical schools
- Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018
- Heteroplasmy in the complete chicken mitochondrial genome
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- Appropriate management of acute gastroenteritis in Australian children: A population-based study
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- Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
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- Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis
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- Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma
- Comparison of Humphrey Field Analyzer and imo visual field test results in patients with glaucoma and pseudo-fixation loss
- Out-of-pocket expenditure and catastrophic health expenditure for hospitalization due to injuries in public sector hospitals in North India
- Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
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- The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer
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- Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea
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- Evolution of high tooth replacement rates in theropod dinosaurs
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- Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology
- Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
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- Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
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- A global overview of cassava genetic diversity
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- Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress
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- Finding phrases: On the role of co-verbal facial information in learning word order in infancy
- Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
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- Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
- Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
- Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
- Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
- Effect of caffeine on neuromuscular function following eccentric-based exercise
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- Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
- Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
- Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
- Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
- Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
- Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
- Ecohydrology of urban trees under passive and active irrigation in a semiarid city
- Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
- LFastqC: A lossless non-reference-based FASTQ compressor
- Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
- Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
- A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
- Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
- The effect of climate change on cholera disease: The road ahead using artificial neural network
- Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
- Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
- Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
- Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
- Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
- Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
- Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
- Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
- Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
- One-year follow-up of changes in refraction and aberrations induced by corneal incision
- Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
- An assessment of the Dutch experience with health insurers acting as healthcare advisors
- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
- Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
- Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
- Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
- Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
- Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
- Histochemical quantification of collagen content in articular cartilage
- Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
- Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
- Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
- Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
- Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
- Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
- Maternal serum and cord blood leptin concentrations at delivery
- Winter nitrification in ice-covered lakes
- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
- Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
- Can adoption of pollution prevention techniques reduce pollution substitution?
- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
- Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
- Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
- Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
- Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
- Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
- Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
- Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
- Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
- Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
- A smart tele-cytology point-of-care platform for oral cancer screening
- Vasopressin SNP pain factors and stress in sickle cell disease
- Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
- Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
- Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
- Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
- Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
- Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
- UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
- Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
- Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
- Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
- Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
- Cassava yield traits predicted by genomic selection methods
- Verification of hub genes in the expression profile of aortic dissection
- Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
- Metabolomic response of Euglena gracilis and its bleached mutant strain to light
- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
- Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
- Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
- Qualification programmes for immigrant health professionals: A systematic review
- An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
- Grain filling of early-season rice cultivars grown under mechanical transplanting
- Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
- Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
- How to design a dose-finding study on combined agents: Choice of design and development of R functions
- Altered expression of Notch1 in Alzheimer's disease
- The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
- Trunk velocity-dependent Light Touch reduces postural sway during standing
- Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
- Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
- Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
- Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
- Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
- Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
- Contingent negative variation during a modified cueing task in simulated driving
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
- Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
- Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
- Brazilian norms for the Bank of Standardized Stimuli (BOSS)
- Distinct varieties of aesthetic chills in response to multimedia
- Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- New formulation of the Gompertz equation to describe the kinetics of untreated tumors
- Development of visual perception of others’ actions: Children’s judgment of lifted weight
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
- Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
- Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
- Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
- Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
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- Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
- Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
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- Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
- Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
- Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
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- Force field generalization and the internal representation of motor learning
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- Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
- The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
- scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
- Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
- Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
- Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
- Post-treatment Lyme disease symptoms score: Developing a new tool for research
- Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
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- Investigating cooperation with robotic peers
- Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
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- A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
- Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
- Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
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- Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
- Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
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- Conceptual fluency in inductive reasoning
- Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
- Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
- Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
- Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
- Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
- Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
- Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
- Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
- The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
- Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
- HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
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- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
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- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
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- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
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- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
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- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
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- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
- Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
- Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
- Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
- Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
- Are primary school children attending full-day school still engaged in sports clubs?
- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Establishing an infrastructure for collaboration in primate cognition research
- Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
- Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
- Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
- The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
- Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
- Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
- Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
- Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
- A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
- Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
- Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
- I’ve been robbed! – Can changes in floral traits discourage bee pollination?
- Visualising statistical models using dynamic nomograms
- Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
- Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
- The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
- Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
- Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
- Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
- iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
- The detection of a non-anemophilous plant species using airborne eDNA
- Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
- Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
- Randomized methods to characterize large-scale vortical flow networks
- Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
- Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
- Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
- Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
- DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
- Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
- Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
- Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
- Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
- Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
- Price dispersion of generic medications
- Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
- The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
- Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
- Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
- Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
- Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
- The performance of practitioners conducting facial comparisons on images of children across age
- Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
- Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
- Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
- Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
- Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
- Mixed methods grant applications in the health sciences: An analysis of reviewer comments
- Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
- Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
- Willingness to receive institutional and community-based eldercare among the rural elderly in China
- An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
- Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
- A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
- Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
- Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
- The fight against polio through the NO-DO newsreels during the Francoism period in Spain
- Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
- Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
- The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
- How medical professional students view older people with dementia: Implications for education and practice
- An enhanced nonparametric EWMA sign control chart using sequential mechanism
- Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
- Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
- Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
- Adsorption of oxytetracycline on kaolinite
- Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
- The role of resource transfer in positive, non-additive litter decomposition
- The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
- Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
- Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
- The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
- Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
- Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
- Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
- The winner takes it all—Competitiveness of single nodes in globalized supply networks
- Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
- Correction: Liquid biopsies for omics-based analysis in sentinel mussels
- Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
- Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
- A model-based framework for chronic hepatitis C prevalence estimation
- Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
- Clinical determinants of social media use in individuals with schizophrenia
- Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
- An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
- A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
- Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
- Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
- Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
- Prediction of disease-related metabolites using bi-random walks
- Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
- Biomarker discovery in inflammatory bowel diseases using network-based feature selection
- The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
- Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
- Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
- Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
- Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
- Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
- Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
- “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
- Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
- Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
- Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
- Treatment of Urethral Pain Syndrome (UPS) in Sweden
- Migration and political polarization in the U.S.: An analysis of the county-level migration network
- Epidemiology and complications of late-onset sepsis: an Italian area-based study
- The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
- Association between trunk and gluteus muscle size and long jump performance
- Multimorbidity and complex multimorbidity in Brazilian rural workers
- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
- Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
- Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
- Sample size issues in multilevel logistic regression models
- Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
- Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
- Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
- The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
- Mouse movement measures enhance the stop-signal task in adult ADHD assessment
- Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
- Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
- Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
- Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
- Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
- Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
- SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
- Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
- Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
- Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
- Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
- Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
- Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
- Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
- Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
- In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
- Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
- Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
- Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
- Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
- Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
- Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
- Outcome of patients with heart failure after transcatheter aortic valve implantation
- Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
- Social information use in adolescents: The impact of adults, peers and household composition
- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
- Comparative studies of two generations of NanoString nCounter System
- General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
- Can altered magnetic field affect the foraging behaviour of ants?
- Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
- A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
- Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
- Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
- Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
- Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
- Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
- Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- Improved chemotherapy modeling with RAG-based immune deficient mice
- Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
- The internal realities of individuals with type 2 diabetes – a functional framework of self-management practices via Grounded Theory approach
- Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
- eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
- Smoking and other determinants of bone turnover
- Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
- School engagement of children in early grades: Psychometric, and gender comparisons
- Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
- Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
- Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
- Location, location, location: Close ties among older continuing care retirement community residents
- Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
- Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
- Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
- Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
- Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
- Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
- Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
- Maximum parsimony interpretation of chromatin capture experiments
- Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
- Estimating measures of latent variables from m-alternative forced choice responses
- Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
- First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
- The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
- Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
- Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
- Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
- Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
- Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
- Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
- Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
- Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
- The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
- Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
- Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
- A Q fever outbreak associated to courier transport of pets
- Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
- Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
- Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
- Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
- Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
- Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
- The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
- International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
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