Trading Places—Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold

1. Rouault TA Mammalian iron-sulphur proteins: novel insights into biogenesis and function. Nat Rev Mol Cell Biol 2015;16 : 45–55. doi: 10.1038/nrm3909 25425402

2. Black KA, Dos Santos PC. Shared-intermediates in the biosynthesis of thio-cofactors: Mechanism and functions of cysteine desulfurases and sulfur acceptors. Biochim Biophys Acta. 2014; epub ahead of print.

3. Stehling O, Wilbrecht C, Lill R. Mitochondrial iron-sulfur protein biogenesis and human disease. Biochimie. 2014; 100 : 61–77. doi: 10.1016/j.biochi.2014.01.010 24462711

4. Blanc B, Gerez C, Ollagnier de Choudens S Assembly of Fe/S proteins in bacterial systems: Biochemistry of the bacterial ISC system. Biochim Biophys Acta. 2014; epub ahead of print.

5. Wiedemann N, Urzica E, Guiard B, Muller H, Lohaus C, Meyer HE, et al. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J. 2006; 25 : 184–195. 16341089

6. Zheng L, Cash VL, Flint DH, Dean DR Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii. J Biol Chem. 1998; 273 : 13264–13272. 9582371

7. Bridwell-Rabb J, Iannuzzi C, Pastore A, Barondeau DP. Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis. Biochemistry 2012; 51 : 2506–2514. doi: 10.1021/bi201628j 22352884

8. Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, et al. Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS. Nat Struct Mol Biol. 2009; 16 : 390–396. doi: 10.1038/nsmb.1579 19305405

9. Muhlenhoff U, Richhardt N, Ristow M, Kispal G, Lill R The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet. 2002; 11 : 2025–2036. 12165564

10. Roche B, Huguenot A, Barras F, Py B. The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli. Mol Microbiol 95 : 605–623. doi: 10.1111/mmi.12888 25430730

11. Vivas E, Skovran E, Downs DM (2006) Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo. J Bacteriol. 2015; 188 : 1175–1179.

12. Parent A, Elduque X, Cornu D, Belot L, Le Caer JP, Grandas A, et al. Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols. Nat Commun 2015; 6 : 5686. doi: 10.1038/ncomms6686 25597503

13. Bridwell-Rabb J, Fox NG, Tsai CL, Winn AM, Barondeau DP Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry. Biochemistry. 2014; 53 : 4904–4913. doi: 10.1021/bi500532e 24971490

14. Yoon H, Knight SA, Pandey A, Pain J, Turkarslan S, Pain D. Turning Saccharomyces cerevisiae into a frataxin-independent organism. PLOS Genetics 2015; this issue.

15. Roche B, Agrebi R, Huguenot A, Ollagnier de Choudens S, Barras F. Turning Escherichia coli into a frataxin-depedent organism. PLOS Genetics. 2015; this issue.

16. Yoon H, Knight SA, Pandey A, Pain J, Zhang Y, Pain D, et al. Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria. Biochem J. 2014; 459 : 71–81. doi: 10.1042/BJ20131273 24433162