An elevated triglyceride level is generally considered a risk factor for the development of type-2 diabetes. However, recent studies suggest, somewhat paradoxically, that genetic risk for elevated triglycerides may protect against type-2 diabetes. In this study, we test the relationship of triglyceride-associated genetic variants, collectively and individually, with incident type-2 diabetes across three prospective cohort studies comprised of European - and African-American participants. Our findings across studies, racial groups, and statistical models consistently demonstrate that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. These genes therefore appear to both increase triglyceride levels and decrease type-2 diabetes risk. More work is needed to understand the physiological mechanism underlying these findings, and to determine the causal relationship between triglycerides and type-2 diabetes.
Vyšlo v časopise: Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes. PLoS Genet 11(5): e32767. doi:10.1371/journal.pgen.1005204 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005204
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