Transfer of Immunity from Mother to Offspring Is Mediated via Egg-Yolk Protein Vitellogenin

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Insects lack antibodies, the carriers of immunological memory that vertebrate mothers can transfer to their offspring. Yet, it has been shown that an insect mother facing pathogens can prime her offspring’s immune system. To date, it has remained enigmatic how insects achieve specific trans-generational immune priming despite the absence of antibody-based immunity. Here, we show this is made possible via an egg-yolk protein binding to immune elicitors that are then carried to eggs. This yolk protein, called vitellogenin, is able to bind to different bacteria and pathogenic pattern molecules. We use E. coli fragments as a bait to show how vitellogenin is necessary for the carrying of immune elicitors to eggs. These findings help to understand how insects fight pathogens and can be useful for protection of ecologically and economically important insects, such as the honey bee, that we used as a model species.

Vyšlo v časopise: Transfer of Immunity from Mother to Offspring Is Mediated via Egg-Yolk Protein Vitellogenin. PLoS Pathog 11(7): e32767. doi:10.1371/journal.ppat.1005015
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005015

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