Vaccination Drives Changes in Metabolic and Virulence Profiles of

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The bacterium Streptococcus pneumoniae is a major cause of life-threatening pneumonia, septicaemia and meningitis worldwide. Pneumococci are covered by a polysaccharide capsule of which there are over 90 distinct serotypes. Available vaccines target a small subset (either 7, 10 or 13) of these capsular serotypes but, following their introduction, increases in the relative amount of disease caused by non-vaccine serotypes have been observed in several countries. Here we offer an alternative explanation for this phenomenon to the traditional concept of Vaccine-Induced-Strain-Replacement whereby the removal of interference from vaccine strains allows non-vaccine strains to fill the niches left vacant by them. We show, instead, that vaccination induces genotypic changes among non-vaccine strains which can lead to an increase in both transmissibility and virulence. Using a mathematical model of genomic evolution, in which strains are split into antigenic, metabolic and virulence-associated components, we show that metabolic and virulence-associated components originally associated with vaccine serotypes become associated with non-vaccine serotypes following vaccination. We term this Vaccine-Induced-Metabolic-Shift and propose that it explains post-vaccine changes observed in pneumococcal population structure in a number of locations worldwide.

Vyšlo v časopise: Vaccination Drives Changes in Metabolic and Virulence Profiles of. PLoS Pathog 11(7): e32767. doi:10.1371/journal.ppat.1005034
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005034

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