Cross Kingdom Activators of Five Classes of Bacterial Effectors

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12. Coburn J, Kane AV, Feig L, Gill DM. Pseudomonas aeruginosa exoenzyme S requires a eukaryotic protein for ADP-ribosyltransferase activity. The Journal of biological chemistry. 1991;266(10):6438–46. 1901061

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19. Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, et al. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science. 1999;285(5435):1920–3. 10489373

20. Mittal R, Peak-Chew SY, Sade RS, Vallis Y, McMahon HT. The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate. The Journal of biological chemistry. 2010;285(26):19927–34. doi: 10.1074/jbc.M110.126581 20430892

21. Lee AH, Hurley B, Felsensteiner C, Yea C, Ckurshumova W, Bartetzko V, et al. A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. PLoS pathogens. 2012;8(2):e1002523. doi: 10.1371/journal.ppat.1002523 22319451

22. Lupardus PJ, Shen A, Bogyo M, Garcia KC. Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science. 2008;322(5899):265–8. doi: 10.1126/science.1162403 18845756

23. Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B, Lacy DB. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. The Journal of biological chemistry. 2009;284(33):21934–40. doi: 10.1074/jbc.M109.018929 19553670

24. Ray S, Taylor M, Banerjee T, Tatulian SA, Teter K. Lipid rafts alter the stability and activity of the cholera toxin A1 subunit. The Journal of biological chemistry. 2012;287(36):30395–405. doi: 10.1074/jbc.M112.385575 22787142

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26. Drum CL, Yan SZ, Bard J, Shen YQ, Lu D, Soelaiman S, et al. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002;415(6870):396–402. 11807546

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29. Yahr TL, Vallis AJ, Hancock MK, Barbieri JT, Frank DW. ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. Proceedings of the National Academy of Sciences of the United States of America. 1998;95(23):13899–904. 9811898

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33. Gottle M, Dove S, Kees F, Schlossmann J, Geduhn J, Konig B, et al. Cytidylyl and uridylyl cyclase activity of Bacillus anthracis edema factor and Bordetella pertussis CyaA. Biochemistry. 2010;49(26):5494–503. doi: 10.1021/bi100684g 20521845

34. Bahre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, et al. cCMP and cUMP occur in vivo. Biochemical and biophysical research communications. 2015.

35. Trasak C, Zenner G, Vogel A, Yuksekdag G, Rost R, Haase I, et al. Yersinia protein kinase YopO is activated by a novel G-actin binding process. The Journal of biological chemistry. 2007;282(4):2268–77. 17121817

36. Lee WL, Grimes JM, Robinson RC. Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization. Nature structural & molecular biology. 2015;22(3):248–55.

37. Grishin AM, Condos TE, Barber KR, Campbell-Valois FX, Parsot C, Shaw GS, et al. Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG. Structure. 2014;22(6):878–88. doi: 10.1016/j.str.2014.04.010 24856362

38. Pruneda JN, Smith FD, Daurie A, Swaney DL, Villen J, Scott JD, et al. E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. The EMBO journal. 2014;33(5):437–49. doi: 10.1002/embj.201386386 24446487

39. Zhou Y, Dong N, Hu L, Shao F. The Shigella type three secretion system effector OspG directly and specifically binds to host ubiquitin for activation. PloS one. 2013;8(2):e57558. doi: 10.1371/journal.pone.0057558 23469023

40. Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(39):14046–51. 16162672

41. Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K. Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins. PloS one. 2014;9(8):e104387. doi: 10.1371/journal.pone.0104387 25099122

42. Coaker G, Falick A, Staskawicz B. Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin. Science. 2005;308(5721):548–50. 15746386

43. Coaker G, Zhu G, Ding Z, Van Doren SR, Staskawicz B. Eukaryotic cyclophilin as a molecular switch for effector activation. Molecular microbiology. 2006;61(6):1485–96. 16968222

44. Aumuller T, Jahreis G, Fischer G, Schiene-Fischer C. Role of prolyl cis/trans isomers in cyclophilin-assisted Pseudomonas syringae AvrRpt2 protease activation. Biochemistry. 2010;49(5):1042–52. doi: 10.1021/bi901813e 20050698

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