ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin

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We have previously demonstrated that ExoT is both necessary and sufficient to induce potent apoptosis in host epithelial cells in a manner that depends primarily on its ADP-ribosyltransferase (ADPRT) domain activity. However, the molecular basis underlying ExoT/ADPRT-induced apoptosis remains unknown. In this study, we demonstrate that ExoT/ADPRT by targeting the adaptor protein Crk, transforms this innocuous cellular protein into a cytotoxin that induces atypical anoikis by disrupting the focal adhesion sites which in turn interferes with the integrin-mediated pro-survival signaling.

Vyšlo v časopise: ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. PLoS Pathog 11(5): e32767. doi:10.1371/journal.ppat.1004934
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004934

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