Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus Infections

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The facility with which viruses evolve underlies many of the problems they cause. Virus evolution is the reason we need a new flu vaccine each year. It’s how HIV and other viruses develop drug resistance. And it enables viruses to occasionally jump from animals to humans and cause new diseases. It is therefore important to understand how and under what circumstances viruses evolve. The arenaviruses are a group of viruses that infect mammals and snakes. Mammalian arenaviruses normally infect rodents but they can also infect humans, and, when they do severe and sometimes fatal disease can result. In this study, we studied genetic diversity in arenaviruses infecting captive snakes. We discovered an astonishing amount of diversity. Most snakes are infected by more than one virus strain, and these strains are merging and shuffling their genes (they are undergoing recombination and reassortment). The extent to which this is happening is exceptional, and has likely been caused by the importation and mixing in captivity of infected snakes from the wild. This provides an excellent opportunity to study the processes of virus evolution and may be an example of human activity altering its course.

Vyšlo v časopise: Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus Infections. PLoS Pathog 11(5): e32767. doi:10.1371/journal.ppat.1004900
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004900

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