Activation of Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type . Typhi Challenge Model

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In this manuscript, we describe, for the first time, a potential role for regulatory T cells (Treg) as an important factor in determining disease outcome in humans following exposure to wild-type S. Typhi. We studied in considerable depth the modulation of Treg activation characteristics and their homing potential in the development of typhoid disease following a wild-type S. Typhi challenge in a unique human infection model. We show that S. Typhi-specific up-regulation of the gut homing molecule integrin α4β7 pre-challenge is associated with subsequent development of typhoid disease. We further demonstrate that increased S. Typhi-specific expression of molecules associated with Treg activation as well as distinct kinetics of the expression of key activation molecules involved in Treg function are present in volunteers diagnosed with typhoid disease. We also provide the first evidence that Treg can functionally suppress S. Typhi-specific CD8+ T cells in vitro. These intriguing results suggest that Treg are likely to play a role in the development of typhoid fever and potentially other enteric infections.

Vyšlo v časopise: Activation of Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type . Typhi Challenge Model. PLoS Pathog 11(5): e32767. doi:10.1371/journal.ppat.1004914
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004914

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