Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity

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African trypanosomes are parasites that cause sleeping sickness in humans. In mice models, trypanosomiasis causes loss of the spleen memory B-cell precursors, of the host memory response and of protection against certain pathogens, built up by vaccination. The phenomenon has never been studied in human sleeping sickness, but if occurring, revaccination after treatment would be required. We show that gambiense human sleeping sickness is associated with a relevant increase in memory T -⁠ and B -⁠ cells in peripheral blood, in particular T-independent memory B-cells. As measles vaccination is included in standard vaccination programs, we measured measles antibody concentrations, which, although slightly lower in sleeping sickness patients than in controls, exceeded in 95% of patients the minimum level considered protective. Anti-red blood cell IgM titres, measured to assess the T-cell independent antibody response, were one titre lower in patients than in controls, but normalized after treatment. Overall, our results in gambiense HAT patients do not suggest trypanosomiasis associated massive memory cell destruction, or loss of antibody levels, although the antibody's protective capacity remains to be confirmed.

Vyšlo v časopise: Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity. PLoS Pathog 10(3): e32767. doi:10.1371/journal.ppat.1003947
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1003947

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