Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study

Autoři: Caroline Morbach aff001;  Bettina N. Walter aff001;  Margret Breunig aff001;  Dan Liu aff001;  Theresa Tiffe aff001;  Martin Wagner aff001;  Götz Gelbrich aff003;  Peter U. Heuschmann aff001;  Stefan Störk aff001
Působiště autorů: Comprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany aff001;  Department of Medicine I, Cardiology, University Hospital Würzburg, Würzburg, Germany aff002;  Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany aff003;  Clinical Trial Center, University Hospital Würzburg, Würzburg, Germany aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0221888



We aimed to provide reference values for speckle-tracking derived systolic and diastolic myocardial deformation markers, and to determine their relation with age, sex, and cardiovascular risk factors.

Methods and results

The Characteristics and Course of Heart Failure STAges A/B and Determinants of Progression (STAAB) cohort study recruited a representative sample of the population of Würzburg, Germany, aged 30–79 years. In a sample of 1818 participants (52% female, mean age 54±12 years) global longitudinal peak systolic strain (GL-PSS, n = 1218), systolic (GL-SSR, n = 1506), and early (GL-EDSR, n = 1506) and late diastolic strain rates (GL-LDSR, n = 1500) were derived from 2D speckle tracking analysis. From a subgroup of 323 individuals without any cardiovascular risk factor, sex- and age-specific reference values were computed. GL-PSS, GL-SSR, and GL-EDSR were associated with sex, GL-EDSR decreased and GL-LDSR increased with age. In the total sample, dyslipidemia was associated with altered GL-PSS, GL-SSR, and GL-EDSR in women but not in men, whereas obesity was associated with less favorable GL-PSS and GL-EDSR in either sex. Hypertension impacted more adversely on systolic and diastolic myocardial deformation in women compared to men (all p<0.01).


The female myocardium appeared more vulnerable to high blood pressure and dyslipidemia when compared to men, while obesity was associated with adverse myocardial deformation in either sex. The reference values for echocardiographic myocardial deformation provided for a non-diseased population and their here reported associations with cardiovascular risk factors will inform future observational and intervention studies regarding i) effect sizes and power calculation, ii) cross-study comparisons, and iii) categorization of myocardial deformation in specific patient groups.

Klíčová slova:

Physical sciences – Physics – Classical mechanics – Deformation – Damage mechanics – Medicine and health sciences – Epidemiology – Medical risk factors – Body weight – Vascular medicine – Blood pressure – Hypertension – Metabolic disorders – Diagnostic medicine – Diagnostic radiology – Echocardiography – Radiology and imaging – Endocrinology – Endocrine disorders – Biology and life sciences – Physiology – Physiological parameters – Obesity – Research and analysis methods – Imaging techniques – Ultrasound imaging – People and places – Population groupings – Age groups


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