Meiosis-Specific Cohesin Component, Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

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Meiosis is a specialized cell division required for the formation of gametes (sperm and egg). Early in meiosis, the chromosome pairs that we inherit from our mother and father become linked and genetic material is exchanged. This is a remarkable process as every gamete that we make is unique, and the unison between a sperm and egg will create a new individual that harbors novel combinations of characteristics from each parents' family tree. Linkage and genetic exchange between chromosomes is facilitated by a linear protein scaffold structure. A group of protein complexes known as cohesins are a key component of the protein scaffold. To date, there are 4 meiosis-specific cohesin complexes identified. Only one cohesin component known as STAG3 is represented in all meiosis-specific cohesins. We mutated the gene that encodes for STAG3 in mouse and discovered that it results in meiotic failure and absence of gametes. From careful analysis we have determined that STAG3 is required for the stability of meiosis-specific cohesins, which ensure that chromosomes are paired and genetic material is exchanged. Our findings imply that abnormalities in human STAG3 will give rise to chromosome defects, infertility and gonad atrophy.

Vyšlo v časopise: Meiosis-Specific Cohesin Component, Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes. PLoS Genet 10(7): e32767. doi:10.1371/journal.pgen.1004413
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004413

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