Hypoxia Adaptations in the Grey Wolf () from Qinghai-Tibet Plateau

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Understanding the genetic mechanisms that allow some individuals to live at high altitudes under hypoxic conditions can provide insight into the evolutionary constraints of adaptation to extreme conditions and the development of hypoxia-related disease in humans. The Tibetan grey wolf (Canis lupus chanco) has long existed on the Qinghai-Tibet Plateau, where low oxygen tension exerts unique selection pressure on individuals. Comparing the complete genome sequences of 4 grey wolves from high altitude and 5 from low altitude, we identify three candidate genes for high-altitude adaptation (EPAS1, ANGPT1, and RYR2) that show strong signals of selection. The three genes potentially enhance function under hypoxic conditions by increasing oxygen delivery (EPAS1 and ANGPT1) and heart (RYR2) function. These genes also appear under selection in high altitude human populations, which suggesting there may be limited pathways for adapting to high altitude existence.

Vyšlo v časopise: Hypoxia Adaptations in the Grey Wolf () from Qinghai-Tibet Plateau. PLoS Genet 10(7): e32767. doi:10.1371/journal.pgen.1004466
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004466

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