#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

preLekára.sk

It's All in the Timing: Too Much E2F Is a Bad Thing

English version České info

article has not abstract

Vyšlo v časopise: It's All in the Timing: Too Much E2F Is a Bad Thing. PLoS Genet 8(8): e32767. doi:10.1371/journal.pgen.1002909
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002909

Souhrn

article has not abstract

Zdroje

1. BiswasAK, JohnsonDG (2012) Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 72(1) 13–17.

2. StevensC, La ThangueNB (2004) The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) 3(8–9): 1071–1079.

3. AsanoM, NevinsJR, WhartonRP (1996) Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev 10(11): 1422–32.

4. ShibutaniS, SwanhartLM, DuronioRJ (2007) Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development 134 : 467–478.

5. ShibutaniST, de la CruzAF, TranV, TurbyfillWJ3rd, ReisT, et al. (2008) Intrinsic negative cell cycle regulation provided by PIP box -⁠ and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell 15(6): 890–900.

6. DavidsonJM, DuronioRJ (2012) S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues. PLoS Genet 8(8): e1002831 doi:10.1371/journal.pgen.1002831.

7. Tanaka-MatakatsuM, XuJ, ChengL, DuW (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326(2): 347–356.

8. MoonNS, Di StefanoL, MorrisEJ, PatelR, WhiteK, et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4(8): e1000153 doi:10.1371/journal.pgen.1000153.

9. KrekW, XuG, LivingstonDM (1995) Cyclin A-kinase regulation of E2F1 DNA binding function underlies suppression of an S-phase checkpoint. Cell 83(7): 1149–1158.

10. CampaneroMR, FlemingtonEK (1997) Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci U S A 94(6): 2221–2226.

Štítky

Genetika Reprodukčná medicína

Článek Mutational Signatures of De-Differentiation in Functional Non-Coding Regions of Melanoma Genomes

Článek Rescuing Alu: Recovery of Inserts Shows LINE-1 Preserves Alu Activity through A-Tail Expansion

Článek Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells

Článek Chromosome Territories Meet a Condensin

Článek Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans

Článek Genome Patterns of Selection and Introgression of Haplotypes in Natural Populations of the House Mouse ()

Článek A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins

Článek Advances in Quantitative Trait Analysis in Yeast

Článek Experimental Evolution of a Novel Sexually Antagonistic Allele

Článek Variation of Contributes to Dog Breed Skull Diversity

Článek , a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome

Článek A Single Origin for Nymphalid Butterfly Eyespots Followed by Widespread Loss of Associated Gene Expression

Článek Cryptocephal, the ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2

Článek Retrovolution: HIV–Driven Evolution of Cellular Genes and Improvement of Anticancer Drug Activation

Článek The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts

Článek A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at and , Selected during Domestication

Článek Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays

Článek Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Článek The Genetic Basis of Pollinator Adaptation in a Sexually Deceptive Orchid

Článek Uncovering the Genome-Wide Transcriptional Responses of the Filamentous Fungus to Lignocellulose Using RNA Sequencing

Článek Inheritance Beyond Plain Heritability: Variance-Controlling Genes in

Článek The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

Článek Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability

Článek Condensin II Promotes the Formation of Chromosome Territories by Inducing Axial Compaction of Polyploid Interphase Chromosomes

Článek PTEN Negatively Regulates MAPK Signaling during Vulval Development

Článek A Dynamic Response Regulator Protein Modulates G-Protein–Dependent Polarity in the Bacterium

Článek Population Genomics of the Facultatively Mutualistic Bacteria and

Článek Components of a Fanconi-Like Pathway Control Pso2-Independent DNA Interstrand Crosslink Repair in Yeast

Článek Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting

Článek Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1

Článek Reprogramming of H3K27me3 Is Critical for Acquisition of Pluripotency from Cultured Tissues

Článek Transgene Induced Co-Suppression during Vegetative Growth in

Článek Hox and Sex-Determination Genes Control Segment Elimination through EGFR and Activity

Článek A Quantitative Comparison of the Similarity between Genes and Geography in Worldwide Human Populations

Článek Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in and Mammals

Článek Comparative Analysis of Regulatory Elements between and by Genome-Wide Transcription Start Site Profiling

Článek Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome

Článek S Phase–Coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues

Článek Cell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of

Článek The Mi-2 Chromatin-Remodeling Factor Regulates Higher-Order Chromatin Structure and Cohesin Dynamics

Článek Comparative Analysis of the Genomes of Two Field Isolates of the Rice Blast Fungus

Článek Role of Mex67-Mtr2 in the Nuclear Export of 40S Pre-Ribosomes

Článek Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program

Článek HAL-2 Promotes Homologous Pairing during Meiosis by Antagonizing Inhibitory Effects of Synaptonemal Complex Precursors

Článek SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Germline

Článek Phylogenetic and Transcriptomic Analysis of Chemosensory Receptors in a Pair of Divergent Ant Species Reveals Sex-Specific Signatures of Odor Coding

Článek Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

Článek Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes

Článek Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1

Článek and Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR

Článek CDK9 and H2B Monoubiquitination: A Well-Choreographed Dance

Článek Rare Copy Number Variations in Adults with Tetralogy of Fallot Implicate Novel Risk Gene Pathways

Článek Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of

Článek NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing

Článek Human Developmental Enhancers Conserved between Deuterostomes and Protostomes

Článek A Luminal Glycoprotein Drives Dose-Dependent Diameter Expansion of the Hindgut Tube

Článek Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11

Článek Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation

Článek Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration

Článek Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

Článek Experimental Relocation of the Mitochondrial Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution

Článek Rates of Gyrase Supercoiling and Transcription Elongation Control Supercoil Density in a Bacterial Chromosome

Článek Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

Článek A General G1/S-Phase Cell-Cycle Control Module in the Flowering Plant

Článek Multiple Roles and Interactions of and in Development of the Respiratory System

Článek UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex

Článek Epigenetic Remodeling of Meiotic Crossover Frequency in DNA Methyltransferase Mutants

Článek Modulating the Strength and Threshold of NOTCH Oncogenic Signals by

Článek Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Článek Acetyl-CoA-Carboxylase Sustains a Fatty Acid–Dependent Remote Signal to Waterproof the Respiratory System

Článek ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

Článek Cohesin Rings Devoid of Scc3 and Pds5 Maintain Their Stable Association with the DNA

Článek The MicroRNA Inhibits Calcium Signaling by Targeting the TIR-1/Sarm1 Adaptor Protein to Control Stochastic L/R Neuronal Asymmetry in

Článek Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

Článek The Genes Define Unique Classes of Two-Partner Secretion and Contact Dependent Growth Inhibition Systems

Článok vyšiel v časopise

PLOS Genetics

2012 Číslo 8

Najčítanejšie tento týždeň

Najčítanejšie v tomto čísle

Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

nový kurz

Autori: doc. MUDr. David Zemánek, Ph.D., MUDr. Anna Chaloupka, Ph.D.

#ADS_BOTTOM_SCRIPTS#