Quadruple Quorum-Sensing Inputs Control Virulence and Maintain System Robustness

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Quorum-sensing (QS) is a microbial cell-cell communication process that allows bacteria to function as a collective group. Many pathogens, including Vibrio cholerae, the causative agent of cholera, depend on QS to regulate important cellular processes that are essential for survival and adaptation inside and outside of their hosts. Since its discovery, the V. cholerae QS system has served as a model to understand how bacterial pathogens employ QS for temporal control of virulence factor production. Yet, after a decade of research, our understanding of the V. cholerae QS system is still incomplete. Here we re-define the QS network architecture of this important pathogen. We show that two novel sensory inputs function in parallel with the two canonical QS pathways to regulate V. cholerae virulence gene expression. Moreover, our study illustrates a strategy that bacteria employ to maintain QS system robustness. By perceiving multiple parallel sensory inputs, the V. cholerae QS network is structured to be highly resistant to signal perturbations, therefore preventing premature commitment to QS. Our study provides new insights into how bacterial pathogens integrate multiple sensory signals to elicit robust and coordinated QS responses.

Vyšlo v časopise: Quadruple Quorum-Sensing Inputs Control Virulence and Maintain System Robustness. PLoS Pathog 11(4): e32767. doi:10.1371/journal.ppat.1004837
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004837

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