Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

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The innate immune system has evolved to detect and neutralize viral invasion. Triggering of this defense mechanism relies on the production and secretion of soluble factors that stimulate an intracellular antiviral defense mechanism. The protein Optineurin was shown to negatively regulate this process. Importantly, we discovered the mechanism by which Optineurin inhibits antiviral activity and showed that this regulation is prevented during a critical step of cell division leading to enhancement of the cellular defense mechanism. This paper shows that the antiviral immune system is controlled during the cell cycle and that Optineurin-mediated induction of this system might serve to protect cells from infection during cell division.

Vyšlo v časopise: Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner. PLoS Pathog 11(4): e32767. doi:10.1371/journal.ppat.1004877
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004877

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