The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection

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Infection of avian influenza virus, especially the highly pathogenic strain H5N1, is a serious threat to public health worldwide, which causes severe fatal respiratory disease and excessive levels of inflammation. It has been reported that both transforming growth factor-beta 1 (TGF-β1) and the integrin CD103 induced by TGF-β1 play protective roles in influenza virus infections. We aimed to find which protein regulates the TGF-β1-integrin cross-talk to protect against H5N1 virus infection. This study provides the first evidence that the intracellular signaling protein ADAP (adhesion and degranulation-promoting adapter protein) up-regulates TGF-β1 production and TGF-β1 induced CD103 expression in CD8+ T cells via the TβRI-TRAF6-TAK1-SMAD3 pathway. Importantly, in response to H5N1 and H1N1 virus infection, ADAP deficiency decreases TGF-β1 production and CD103 expression in lung infiltrating CD8+ T cells with the enhanced mortality in mice. Since various SNPs or mutations in key molecules of TGF-β1 pathway, including polymorphisms located in ADAP/FYB gene, are associated with inflammatory diseases, future work should investigate whether these SNPs or mutations enhance disease susceptibility or clinical manifestations in response to acute influenza virus infection.

Vyšlo v časopise: The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection. PLoS Pathog 11(4): e32767. doi:10.1371/journal.ppat.1004824
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004824

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