Profilin Promotes Recruitment of Ly6C CCR2 Inflammatory Monocytes That Can Confer Resistance to Bacterial Infection

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Toxoplasma gondii is an apicomplexan parasite that can infect all warm blooded animals, but rodent species are considered the primary reservoirs. Mice that are infected with T. gondii become more resistant to lethal infection with other pathogens. Ly6C+ inflammatory monocytes are innate immune cells that are critical for defense against T. gondii and other infections. Mice with defects in the ability to recruit inflammatory monocytes fail to control T. gondii replication and succumb to overwhelming inflammation. In this study we used a co-infection model to explain why T. gondii-infected mice are more resistant to the bacterium Listeria monocytogenes. We show that stimulation of the rodent specific Toll-like receptor TLR11 by the T. gondii ligand profilin can recruit inflammatory monocytes, and that these monocytes can protect the host against L. monocytogenes. These findings make profilin an important tool for the study of monocyte biology during T. gondii infection of rodents and are especially interesting given that TLR11 is nonfunctional in humans and other vertebrates.

Vyšlo v časopise: Profilin Promotes Recruitment of Ly6C CCR2 Inflammatory Monocytes That Can Confer Resistance to Bacterial Infection. PLoS Pathog 10(6): e32767. doi:10.1371/journal.ppat.1004203
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004203

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