A Translocated Effector Required for Dissemination from Derma to Blood Safeguards Migratory Host Cells from Damage by Co-translocated Effectors

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Cell migration, a fundamental feature of eukaryotic cells, plays a crucial role in mounting an effective immune response. However, several pathogens subvert the migratory properties of infected host cells to their benefit, such as using them as Trojan horses to disseminate within the host. Bartonella effector proteins (Beps) are bona fide virulence factors indispensable for the colonization of mammalian target cells. However, their multiple interferences with host cellular signaling processes might culminate in deleterious secondary effects that require additional effectors to maintain the host cell integrity. A striking example is BepE, which is shown here to preserve endothelial cells (ECs) from fragmentation and to inhibit the defects of dendritic cell (DCs) migration caused by BepC and possibly other Beps. Moreover, BepE is essential for Bartonella dissemination from the dermal site of inoculation to the blood stream where bacteria establish long-lasting intraerythrocytic bacteremia as a hallmark of infection in the mammalian reservoir host. Migration of Bartonella-infected DCs through a monolayer of lymphatic ECs was also found to be dependent of BepE, suggesting that BepE is required to preserve the migratory capability of DCs, a candidate cell type for systemic dissemination from the dermal site of inoculation.

Vyšlo v časopise: A Translocated Effector Required for Dissemination from Derma to Blood Safeguards Migratory Host Cells from Damage by Co-translocated Effectors. PLoS Pathog 10(6): e32767. doi:10.1371/journal.ppat.1004187
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004187

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