HopW1 from Disrupts the Actin Cytoskeleton to Promote Virulence in Arabidopsis

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Eukaryotic cells require a dynamic actin cytoskeleton for basic functions, some of which are important for immune responses. Such functions include the transport of cellular material to and from different cellular compartments. The plant pathogen Pseudomonas syringae is extracellular and causes disease by injecting effector proteins into plant cells. One of these effectors is HopW1, which disrupts the actin cytoskeleton and reduces the transport of vesicles from the cell surface and proteins destined for vacuoles. The effects of HopW1 can be mimicked using a drug that inhibits actin polymerization. Thus, this work establishes a direct mechanism for pathogen disruption of the actin cytoskeleton and implicates actin-dependent events as important for controlling pathogen growth during infection.

Vyšlo v časopise: HopW1 from Disrupts the Actin Cytoskeleton to Promote Virulence in Arabidopsis. PLoS Pathog 10(6): e32767. doi:10.1371/journal.ppat.1004232
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004232

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