Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex

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Most HTLV-1-infected individuals are asymptomatic. It is thought that the proviral DNA is transcriptionally inert and HTLV-1 replicates through mitotic expansion of host cells. The evolving provirus integration patterns in HTLV-1 carriers, however, suggest new infection occurs continuously. Whether or how HTLV-1 establishes latency and reactivates is unclear. We show that HTLV-1 infection in culture can lead to two alternative outcomes —⁠ productive infection accompanied by senescence or latent infection followed by clonal expansion —⁠ based on the relative expression of regulatory proteins: Tax, Rex, and HBZ. HTLV-1 latency is established by HBZ, and reactivation is achieved by Rex through regulating nuclear export of viral mRNAs. Elucidating mechanisms underlying HTLV-1 latency and reactivation can facilitate virus control to prevent progression to disease.

Vyšlo v časopise: Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex. PLoS Pathog 10(4): e32767. doi:10.1371/journal.ppat.1004040
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004040

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