Complement-Related Proteins Control the Flavivirus Infection of by Inducing Antimicrobial Peptides

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Hosts are equipped with sophisticated machineries for detecting and eliminating invading viruses before they cause significant physiological damage. Unlike mammals which have both innate and adaptive immune systems, insects rely solely on the innate immune system to limit viral infection. Mosquitoes are natural vectors for many human pathogenic viruses, such as dengue virus (DENV) and yellow fever virus. Despite lacking an immunoglobulin-based humoral response, mosquitoes arm themselves with a functional complement-like system to ward off invading pathogens. Herein, we show that a system composed of complement-related factors recognizes and limits flaviviruses by inducing antimicrobial peptides expression. Understanding antiviral mechanisms in arthropods may provide novel strategies for limiting arboviral transmission in nature.

Vyšlo v časopise: Complement-Related Proteins Control the Flavivirus Infection of by Inducing Antimicrobial Peptides. PLoS Pathog 10(4): e32767. doi:10.1371/journal.ppat.1004027
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004027

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