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Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
Authors: Cheick Sidya Sidibé aff001; Ousmane Touré aff001; Jacqueline E. W. Broerse aff002; Marjolein Dieleman aff002
Authors place of work: Institut National de Formation en Sciences de la Santé, Bamako, Mali aff001; Athena Institute for Research on Innovation and Communication in Health and Life Sciences, Vrije Universiteit, Amsterdam, Netherlands aff002
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0222266Summary
The availability and retention of healthcare professionals in rural areas and remote areas is a challenge to the health sector worldwide. Attracting people who are most likely to be interested in rural practice can be conducive to the sustainable availability of health services in rural areas where health facilities are typically understaffed and existing professionals often underqualified. This article aims to contribute to the rural pipeline evidence, and reports on the findings of a study that investigated the career choices of midwifery and obstetric nurse students in Mali. The article enquires into the relationship between their intention to practice in rural areas and the different components of the rural pipeline. A mixed method study using a survey, semi-structured interviews, and document analysis was conducted from October to December 2017 on third-year midwifery and obstetric nurse students and school-managers. Descriptive statistics and bivariate analysis were performed for quantitative data, and content analysis was carried out for the qualitative data. Key findings suggest that students prefer urban locations for living and for work. The intention to work in rural areas seems to be influenced by the current living situation (currently living in a rural area) or having attended secondary school or professional training in rural areas.
Keywords:
Social sciences – Sociology – People and places – Population groupings – Professions – Geographical locations – Medicine and health sciences – Health care – Women's health – Obstetrics and gynecology – Health care providers – Nurses – Medical personnel – Economics – Africa – Labor economics – Employment – Jobs – Education – Schools – Earth sciences – Geography – Geographic areas – Rural areas – Nursing science – Midwives – Mali
Introduction
Qualified and available health care providers are essential for delivering quality health care and improving the health status of populations. However, there is an acute shortage of qualified professionals in low-income countries that bear the greatest burden of maternal and child illnesses and deaths. According to its latest Demographic and Health Surveys (DHS IV and V), maternal mortality in Mali has declined from 464 to 368 deaths per 100,000 births [1]. But it is still among the highest in the world, far beyond the 70 per 100,000 live births targeted by the Sustainable Development Goals by 2030 [2]. Among factors that contribute to this mortality ratio is the lack of effective health services in rural locations [3,4], and limited access to healthcare services, resulting from a lack and maldistribution of human resources for health. To ensure universal health coverage and to make progress towards the reduction of maternal mortality, achieving equitable distribution of health workers between urban and rural areas is essential. This is particularly crucial for midwives and obstetric nurses, two front-line health professionals in Mali who are qualified to provide health services for pregnant women and newborns. However, the distribution of midwives and obstetric nurses across the health system is very imbalanced. As of 2017 there were an estimated 1,529 midwives in the country with one midwife for 2,775 inhabitants in Bamako, one for 28,348 in Kayes and one for 38,050 in Mopti [4].
Attracting people who are most likely to be interested in rural practice can be conducive to sustainable availability of health services in undeserved and rural areas [5]. Health professionals with a rural background are believed to be more likely to practice in rural locations [6,7]. Attracting students with a rural background to health studies or providing rural exposure to students during their training in an attempt to attract them to rural practice is referred to as rural pipeline [8]. The concept of rural pipeline has four components [9]: i) advocating health professions among rural students, ii) ensuring that more rural students are selected into programs, iii) developing a curriculum oriented towards rural health and rural exposure during training and iv) ensuring retention of health workers in rural areas through educational and professional support. Originally used for medical students, the approach is now applied to all health workers, including midwives and nurses [10].
Various studies and reviews in high - and middle-income countries have contributed to the evidence base of the effects of implementing (parts of) the rural pipeline. Literature reviews on rural school programs attest to the positive impact of rural exposure on increasing attraction of students to rural practice in different settings. Johnson et al. in a 2018 review indicated that rural clinical placement programs and rural clinical schools have a positive association with rural practice locations when they are well designed and financially supported [11]. O’Sullivan et al. in a recent review reported that Australia’s immersion programs are associated with an increased rural supply of doctors at their career debut [12]. A review by MacQueen et al. states that growing up in a rural community is a predictor of choosing a rural practice location [13]. Another review found that medical students attending a rural campus or spending time in a rural area are more likely to practice in non-urban areas after graduation. The longer students engage with rural areas during their training, the more likely they are to work in such areas after graduation [14]. Rabinowitz showed that rural medical school training programs in the United States have increased the number of rural physicians and that their large-scale replication could have a major impact on access to health care for rural communities [15]. Wenghofer et al. [16] studied the rural educational experience of the Northern Ontario School of Medicine and found that 25,4% of their graduates were practicing in rural areas compared to 10,3% for students from other Canadians medical schools. Australia has developed a national program to enhance its rural medical workforce by recruiting students with a rural background and establishing rural clinical schools. Evaluating the regional result of the program, Kwan et al. showed that predictors of long-term rural practice were a rural background, rural clinic schools and bonded scholarships [17]. McGrail et al. explored in Australia the association between the region of practice and the region of rural training, combined with the region of secondary schooling and duration of rural training and the return rate of medical graduates in their rural training region in early career was related to their connection with the region through their medical training and /or their secondary schooling [18]. In United States, the University of Missouri School of Medicine has developed a Rural Track Pipeline Program with a preadmission program for rural students, a Community Program, Rural Track Clerkship and a Rural Track Elective Program for students. Quinn et al. assessed the effect of the program on the residency choice and practice location of students and found that over 57% of students who participated in the rural track clerkship program chose a rural location for their first practice [19]. In Europe, Carson et al. [20] have examined the relationship between rural origin and exposure and the preference for rural jobs in six European countries, finding that both rural origin and rural exposure contribute to the retention in rural areas; but not to the same extent in all contexts. For instance, the rural pipeline is less important for retention of practitioners in rural areas that are very close to cities. In South Africa, Stellenbosch University has successfully implemented rural pipeline in an attempt to strengthen medical education in rural and constrained areas. The rural education intervention has led to change in the attitudes of students towards rural practice. They feel more confident in their preparedness to be a doctor in rural areas [21–23]. In addition, a study by de Vries et al. showed that rural-origin graduates in South Africa are more likely to practice in rural areas than those from urban areas [24].
As in high - and middle-income countries, in low-income countries where health workers shortages in rural and remote areas hamper access to care, studies have shown a positive correlation between rural origin, rural exposure and the students’ likelihood of opting for rural practice [25–30]. In a survey among medical and nursing students from nine African and Asia countries, Silvestri et al. found that a long duration in a rural setting was likely to anticipate selecting a rural practice [25]. In a number of African countries, the same trend is observed. In Rwanda and Ethiopia, students who have grown up in a rural area are more willing to work in a rural area [26]. In the Ghanaian context, medical students with rural experience are shown to be likely to work in a deprived area after graduation [27]. In a pilot program at the University of Nairobi, a decentralized training program demonstrated the positive effects of increasing students’ ability and willingness to work in rural and underserved areas [28]. Uganda’s experience of community-based education for undergraduate health professions students’ resulted in an increased proportion of students who expressed intentions to practice in rural areas [29]. In Niger, a study on the motivations of obstetric healthcare personnel to work in rural areas suggests that rural origin may be a motivator for health workers to accept rural posting [30].
In Mali too, in an attempt to improve accessibility of care particularly in rural areas, initiatives such as the decentralization of training schools in rural regions have been taken during the last decades. According to human resources and schools’ managers, the development of public or private schools in regions has likely contributed to the increase of human resources for health in these areas. For instance, this seems the case of the Gao School of Health (EIG), that revised curricula to include rural health topics and of which 92% of graduates (N = 35 midwives) remained in the region. Other initiatives aimed at retaining staff in rural areas through training have been experimented with. An orientation course on rural practice for newly established rural doctors from 2003 to 2005 contributed to a positive impact on their preparedness for rural practice and increased retention in rural areas, with 50% still in rural practice after 4 years [31].
Overall, evidence shows that rural students’ selection and rural exposure during education has proven to be effective in different contexts. One can hypothesize that such initiatives might be effective in Malian context as well because of the similarities in the behavior of health workers. However, there is yet insufficient evidence whether or not rural pipeline components can be used to develop strategies to attract maternal health work force to rural and remote areas in Mali. This article aims to contribute to the rural pipeline evidence, and reports on the findings of a study that investigated the career choices of midwifery and obstetric nurse students in the Malian context. It looks into the relationship between their intention to practice in rural areas and the different components of the rural pipeline. It specifically focuses on the components of the rural pipeline applied in the Malian context for midwives and obstetric nurses to attract them to rural practice and asks whether there is a relation between the rural pipeline components in place and the intention to practice in rural areas. In this study, we define rural areas as areas located outside main cities and the Bamako region.
Materials and methods
This study was a mixed method study and used a survey, semi-structured interviews and document analysis. Data were collected from October to December 2017.
Study population and sampling
Midwifery and obstetrics nursing students who were enrolled in degree program in health sciences training schools constituted the study population of this study. Schools were selected using a maximum variation sampling strategy based on their attendance rate and their location, so as to include midwifery and obstetric nursing students from different regions and different sectors.
Selection of training schools
The study included six private schools, one (the only) public training school in Mali, and three of its annexes. The public training school, the National Institute for Training in Health Sciences (INFSS), has a central structure in Bamako and four regional schools. It is in charge of research and training of allied health workers in Mali. It provides training at Bachelor (license) and Master levels. Public schools in the regions are annexes of the INFSS and have no autonomy of management and operation. They provide training up to the bachelor level. Three of them have been included in the study. The private schools train midwives and obstetrics nurses. Of the 10 schools involved in the studies, only one was situated in a rural area; two were situated in Bamako and seven in other urban areas. There were no midwife training school located in rural areas. Table 1 gives the overview of training schools involved in the study.
Tab. 1. Overview of sampled training school.
Selection of respondents
For the quantitative component, all midwifery and obstetric nursing students in their last training year at the selected schools were invited to participate. They were contacted in the classroom by researchers at the end of a lecture with request to participate. Those who agreed to participate were included. We conducted a convenience sampling among final year students. Potential participants were asked if they were willing to participate and were interviewed after they had provided consent. School managers were included as key informants. All school managers from selected schools were asked to participate and all of them agreed to. In addition, school managers from a private school, Gao nursing school, in the northern region in Mali (Gao) were included because it is the first and was for many years the only school located in the northern region in Mali. The managers were telephoned with request for interview. After agreeing and giving consent they were interviewed.
Data collection methods and process
For the quantitative component, data collection was done through a survey using a self-administered questionnaire. Questions were asked about personal characteristics, motives to join midwifery or obstetric nursing training, and job preference. The questionnaire was developed and pre-tested and slightly adapted.
For the qualitative component, semi-structured interviews were conducted in a private location with only the participant and the interviewer. For the students, themes explored were career choices, job search strategies, mobility, career aspiration and job preference. For the managers, questions were asked about the organization of the curricula, the availability of support for graduates in finding a job, training policies, and admission and accessibility policies, practices and criteria. Interviews with managers from Kayes, Sikasso, Ségou, Mopti and Gao were done through telephone calls. Interview guides were pre-tested with school managers in Bamako. All interviews were digitally recorded. Each interview lasted about 45 minutes. The interviews were conducted by CSS (Male, MD, PhD student), a male interviewer (MD) and female sociologist (MSc). All the members of the team were trained in qualitative interviewing and were bilingual (French and Bambara). The saturation of the data was obtained during the interviews.
Documents related to training policy and regulation were collected from selected schools when available and analyzed.
Data processing and analysis
Quantitative data were analyzed with IBM SPSS Statistics version 24 using descriptive statistics to describe characteristics of participants. The Chi square test and the Fisher exact test were used for bivariate analysis of students’ characteristics and their intention to work in rural areas. The P value below 0.05 was considered statistically significant.
Following transcription, interview data were transcribed and analyzed using Atlas.ti qualitative software version 8.1.0 (31). A coding framework was developed according to the research objectives and themes, the transcripts were coded and analyzed, comparing and contrasting answers between different groups of respondents, different sources of data collection, and between respondents’ answers and documents.
Ethics approval and consent to participate
Ethical approval for this study was sought and obtained from the Ethics Committee of the National Institute of Research in Public Health (N°23/2017/CE-INRSP). Participation was voluntary. Participants were able to leave the study any time they wanted. Written informed consent to participate was obtained from each study participant except for those interviewed by phone. In these cases we obtained verbal consent.
Results
Result are presented about midwives and combine the perspectives of all participants groups. Data on obstetric nurses are shown when differences are found in comparison to the answers from midwives. We first present rural pipeline components in use, and then students’ perceptions about and willingness to practice in rural areas.
Rural pipeline components in training schools
Strategies to attract students
The training of midwives and obstetric nurses is provided by the public schools and private training structures. Public schools are present in four out of the ten regions in the country and in the District of Bamako. Private schools are present in six regions and the District of Bamako. Administration of public schools have been decentralized to the regions to improve the likelihood that students from these regions will be trained locally and will then continue to work in these areas. None of the training structures have defined strategies for attracting students. According to the managers, schools usually rely on their geographic location, students’ success rate on certification exams.
"We do not have specific strategies. We do not do anything special, not even advertising. It is the performance of our graduates and the rigor in our training that attract students to our structure." (Private school manager, Bamako)
Public institutions also rely on their status as public reference schools to attract students. Entry contest dates are published and announced on radio.
"We do not have attraction strategies. We are the public reference school in the region. Our products are well appreciated. Our interactions with employers and health facilities give us some reputation, and this attracts us students.” (Head of public school in the region)
Currently, only women are attracted to and accepted in the training for midwives and obstetric nurses even though there are no rules that prevent men from registering.
Students’ selection procedure
Two main procedures allow training applicants to access studies: the recruitment competition and the examination of files. The competition is the main means to access public schools and is only available for Malian students. It is open to all students who graduate from secondary schools and are aged less than 22 years. Admission tests are organized in all regions. The majority of the applications usually come from Bamako and the majority of admitted students are from Bamako as well. The students are distributed between INFSS’ structures in Bamako and in the region. Students admitted through this competitive process receive a scholarship for six semesters covering tuition fees and living expenses. In addition to this process, public schools can also recruit students that can pay tuition fees without any competition.
Admission for midwifery training is open to all candidates holding the Baccalaureate Diploma, and for obstetric nurse candidates the diploma of fundamental studies (DEF) without competition. There are no age restrictions. Some institutions test French language proficiency for obstetric nurses. According to a private school manager:
"We carry out tests for obstetric nurses. They must at least be able to understand and write in French. For midwives, they are holders of the baccalaureate. We assume they have the required level in French." (Private school manager, Bamako)
None of the structures, private and public, have preferential selection policies based on the background of the candidates.
School capacities and accessibility
From the document review, it appeared that Mali currently has 115 to 120 private training schools and the public school and its annexes. Most of private school managers indicated that they are training less than the capacity of their schools in regions and in Bamako. However, the total number of graduates both in public and private schools has increased over the past few years from 259 to 340 annually for midwives and from 261 per year in 2013 to a thousand per year in 2017 for obstetric nurses. This is due essentially to the increased number of training schools.
Tuition fees, according to school officials, can be a barrier to accessibility especially for rural students. Indeed, the annual costs of the tuition vary from 320 000 in public school and to 450 000 CFA (1US$ = 500CFA) in private schools, excluding living expenses. This is a large amount of money in rural areas where more than 55% live below the poverty line. However, these managers think that this training cost may help provide better training for those who are able to pay.
Rural exposure and curricula content for rural practice
Currently there are two different curricula in use for midwifery training. The first, objectives-based curricula, which is used in most private schools dates back to 2003. It is being used exclusively in the private sector since 2008. The second curriculum is competency based and developed by the West African Health Organization (WHAO). It has been used by the public school since 2012 and some of the private schools since 2016. For the obstetric nurses, there is only one curriculum, which was developed in 1998. According to school managers, private and public, students are trained to work in rural areas as well as in urban areas at all levels of the health system. However, most of the training takes place in urban areas. Clinical training is done in urban primary health facilities (CSComs) for first - and second-year students and mostly in referral health centers (CSRéf) and hospitals for the final-year students.
There is a policy, for both public and private schools, of exposing students to rural practice in order to familiarize them with the conditions of practice in these environments. This rural placement currently takes place at the end of the final year as part of the final examination process. Students are exposed to clinical experience in rural communities for 45 days without formal and structured teaching or supervision by teaching staff. Students are supervised by local health care providers, generally other midwives or obstetric nurses. However, despite this mandatory policy, the mandatory internships do not always take place in rural areas. Locations for internships for the public-school students are identified each year from a prospection process, and students are randomly assigned to facilities. Health facilities that are chosen to host students are generally those that are easy to reach or those that provide accommodations for students. Unlike students in public school, students from private schools benefit from little or no support for internship in rural areas. Students from private schools pay the travel cost and other expenses for living themselves. For these reasons, students from private structures are allowed to choose their internship locations. As a result, most of the students choose to stay close to or in major cities and in CSRéf.
During the rural internship, students, both from private and public schools, do clinical activities and a community diagnostic survey to identify priority health issues in the community. The rural practice is assessed through a report produced by students. Like midwifery students, obstetric nursing students are exposed to rural practice at the end of their three-year training. They are supervised by midwives and doctors.
Students’ perceptions on willingness to practice in rural areas
These findings are based on data from the questionnaire. In total 186 students aged 17 to 42 years participated in the survey. Participants were midwifery students (39.8%, n = 74) and obstetric nursing students (60.2%, n = 112). Table 2 shows that 57% were married, more than one third were born in a rural area, 11.3% are currently living in a rural area, and 3.8% are being trained in a school located in a rural area. All students in the private sector are paying tuition. In the public schools there are students in paid tuition, but the majority are scholarship holders.
Tab. 2. Students’ characteristics and likelihood to work in rural areas.
Relation between students’ background and job preference
Most of the students mentioned that entering the training was a personal choice. Qualitative data shows that the students have an altruistic vision of their profession. The main reasons for choosing the profession are "helping others", "saving lives", and some have been attracted by "the prestige of the profession". Most of them have relatives who are health workers.
Two-thirds (66.7%) of the students would like to work immediately upon graduation. Preferred job location were urban facilities (79.6%, n = 148). Most students would like to work in the public sector (91.4%; n = 170) and as civil servants (86.5%, n = 161). There were no differences in the intention between midwives and obstetric nurses. (Cf Table 3). They all would like to work as service providers in maternal health or nutrition or as trainers.
Tab. 3. Job preferences.
Qualitative data found that students prefer to serve as civil servants in the public sector because they believe that that will make care more accessible to the population, guarantee them job stability, and bring them more respect from other care providers as a civil servant status is reputedly more difficult to reach. The majority of students would prefer to work in CSRef or hospitals because of the level of equipment, the workload and the level of service: "We lose the hand in cscom. There is no equipment to do the job” (Midwifery student). Some students would prefer to avoid working in hospitals were you only have “complicated cases” managed by doctor unlike CSCom and CSRéf” (Midwifery student).
For those who did not want to work immediately upon graduation, the reasons were the intention to undertake further training like the masters degree for midwives and midwifery diploma for obstetric nurses, or to get married and have children first. Some were enrolled in other training programs and would prefer to work with those degrees.
Likelihood to work in rural areas
We found that less than 20% (n = 38) of students would like to go and work in a rural area. Midwifery students were more likely to go to rural areas (32.4%, n = 24) than obstetric nursing students (12.5%, n = 14) (p = 0,01). Current living location in rural areas (47.6%, n = 10) (p = 0.003) and having professional school located in rural areas (57.1%, n = 4) (p = 0.03) and having had secondary education in rural areas (38.5%) (p = 0.01) were associated with greater intention to go in rural areas. Table 2 shows that 24.2% of students who were born in a rural area and 25.9% of those who had their primary school in rural areas show preference for practice in a rural setting but the links are not statistically significant. Marital status and place of birth did not statistically link to preference for a rural posting.
The reasons for preference for rural areas, given in the interviews, are being closer to the population, autonomy, less favoritism, and the feeling of being useful, as illustrated by the following quote of an obstetric nurse student:
“Certainly, there is not much work in rural areas compared to urban areas, but the trust that exists between rural populations and health workers makes me prefer these environments. There are few health workers, you can easily feel useful.” (Obstetric nurse student)
Aspects that were mentioned by students to be important to attract them to rural areas were: having the equipment to do the job properly, proximity to the family or easy access to cities and good housing conditions.
Discussion
This study aimed to identify components of the rural pipeline applied in the Malian context to attract midwives and obstetric nurses to rural practice, the students' inclination to practice in rural health care settings and the relation between the rural pipeline components in place and intention to practice in rural areas. Key findings suggest that there is effort at the level of the curricula to provide students with rural exposure. The other components of rural pipeline like promotion of health professions among rural students and ensuring rural students’ selection into programs are not in place. Students generally prefer urban locations for living and for work. The factors associated with the intention to work in rural areas are currently living in or having attended professional or secondary school in a rural area.
Benefits of getting students from rural areas in health care profession training have been documented both in high - and in low income-countries [12,13,25]. This has been acknowledged by the government in Mali, which has led to the decentralization of public schools in regions and to granting permission to private schools to train health workers in rural areas. Nevertheless, while the proportion of midwives’ and obstetric nurses’ students has increased in the past few years, the proportion of students with rural background remains low. This could be due in part to the absence of promotion strategies of healthcare professions among students from rural areas. It could also be due to the difficulty of accessibility, both financially and geographically, of training students from rural areas. The level of poverty in most of the Malian rural settings make the training financially less accessible to rural students compared to those from urban areas if they do not get a scholarship. For the geographical accessibility, most of the schools are located in urban areas and none of the schools that train midwives are situated in rural areas. Another reason may be the limited pool of possible students in rural areas where 71% of secondary school-aged children are out of school and only 17% are attending secondary school [32].
There is no preferential selection policy currently in place in any of the training schools. Private schools rely on cost recovery from tuition payment. In public schools, half of the students were paying tuition fees. Scholarship is offered to some students in public schools by the government. But this is supposed to be done on the basis of an equal chance for all and is thus not exclusive for rural students. Most of the students who benefit are from urban areas, especially Bamako. When students are required to pay tuition fees, usually in private schools, beside the academic requirements to enter the training, the sole selection criteria applied are students’ capacities to pay tuition fees.
Due to the limited pool of possible students in rural areas and because of the limited availability of health facilities and trainers in rural areas, it may be difficult to establish training school for midwives in rural areas in Mali. What is feasible is providing rural exposure to students and having a curriculum with contents oriented to rural practice. This has proven to be effective in attracting students in rural practice in other settings [17]. Currently in Mali, there is little rural practice-oriented contents in midwives’ training curricula. The duration of rural exposure during training is very limited. It occurs only after completion of the third year of study and lasts for 45 days. Rural exposure appears to be more effective when students can benefit from earlier, frequent and longer exposure to rural practice [14]. Because the exposure occurs solely at the end of the training cycle, students actually do not benefit from structured teaching and supervision in rural areas. They do not have the opportunity to discuss and to propose adjustments in training in order to prepare them to face situations they may encounter during the rural placement. Literature suggests that to be a pull factor, rural exposure ought to provide students with a positive experience of their internships through quality coaching and working conditions. Failing this, it may, on the contrary, constitute a push factor [11]. Regarding these criteria, the current quality of rural exposure is not sufficient to ensure attraction for rural practice.
Study limitations
It should be mentioned that our research focused on students’ preferences and these may be different from the choices of graduated midwives. Thus, further studies may be necessary to explore the relation between graduated midwives and obstetric nurses’ job preference and retention in the context of the rural pipeline in Mali. Another limitation would be the fact that we used convenience sampling and thus included those who were willing to participate, which may have caused bias.
Conclusion
Currently, of the components of the rural pipeline (advocating health professions among rural students, ensuring that more rural students are selected into programs, developing a curriculum oriented towards rural health and rural exposure during training) examined in this study, only exposure to rural practice is implemented in the training facilities in Mali for the training of midwives and obstetric nurses. However, the duration and timing of this rural practice are not conducive to providing the desired effects on the willingness of final year students to work in rural areas. In addition, current selection procedures, especially in decentralized public schools, are not effective in providing locally trained qualified personnel for rural areas with staff shortages.
Supporting information
S1 File [pdf]
Guide in French.S2 File [pdf]
Guide in English.S3 File [pdf]
Questionnaire in French.S4 File [pdf]
Questionnaire in English.
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- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
- Comparing infiltration rates in soils managed with conventional and alternative farming methods: A meta-analysis
- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
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- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
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- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
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- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
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