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The Role of China in the Global Spread of the Current Cholera Pandemic


Cholera is a life-threatening, diarrheal disease caused by the bacterium Vibrio cholerae. After a long interregnum of decades without epidemics, the seventh cholera pandemic spread globally since 1961, causing considerable morbidity and mortality. Our analysis of published and newly sequenced genomes provides details on genetic groupings within V. cholerae, so-called clades, that have developed during the recent pandemic spread of these bacteria, and, in some cases, persisted to modern times. We reconstructed some of the pathways taken by the current pandemic since its origins in Indonesia, and show that both South Asia and East Asia are important pathogenic reservoirs and sources of international transmissions.


Vyšlo v časopise: The Role of China in the Global Spread of the Current Cholera Pandemic. PLoS Genet 11(3): e32767. doi:10.1371/journal.pgen.1005072
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005072

Souhrn

Cholera is a life-threatening, diarrheal disease caused by the bacterium Vibrio cholerae. After a long interregnum of decades without epidemics, the seventh cholera pandemic spread globally since 1961, causing considerable morbidity and mortality. Our analysis of published and newly sequenced genomes provides details on genetic groupings within V. cholerae, so-called clades, that have developed during the recent pandemic spread of these bacteria, and, in some cases, persisted to modern times. We reconstructed some of the pathways taken by the current pandemic since its origins in Indonesia, and show that both South Asia and East Asia are important pathogenic reservoirs and sources of international transmissions.


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Genetika Reprodukčná medicína

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