Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates

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Prions, the infectious agents responsible for causing mad cow disease, amongst other diseases, can transmit from one species to another. For example, Bovine Spongiform Encephalopathy can transmit to humans resulting in invariably fatal variant Creutzfeldt-Jakob Disease. We wanted to study the susceptibility of rabbits as, until recently, they were considered a prion resistant species. Once proven otherwise, we wanted to know which particular prions rabbits were susceptible to. With this aim, a transgenic mouse was designed expressing the rabbit prion protein gene instead of the corresponding mouse gene to model the transmission barrier between rabbits and other species. The resultant mice where challenged with several field prion isolates including classical and atypical strains of Bovine Spongiform Encephalopathy, sheep Scrapie and cervid Chronic Wasting disease. The transgenic mice were susceptible to classical and atypical Bovine Spongiform Encephalopathy prions and also to mouse-adapted Scrapie prions. This information must be taken into account when assessing the risk of using ruminant derived protein as a protein source to feed rabbits.

Vyšlo v časopise: Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates. PLoS Pathog 11(8): e32767. doi:10.1371/journal.ppat.1004977
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004977

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