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: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with


In this work we performed a comprehensive evaluation of the infective potential of Leptomonas seymouri, repeatedly isolated from kala-azar patients infected by Leishmania donovani in India and neighboring countries, and have tested the capacity of this monoxenous trypanosomatid to utilize the sand fly vectors permissive for Leishmania donovani. We concluded that despite several genetic adaptations it has developed, Leptomonas seymouri remains a predominantly monoxenous species not able to infect mammalian macrophages either alone or in co-infection with Leishmania. Under certain circumstances it is able to infect mammals, but probably only when the host is immunocompromised by infection with another pathogen, such as Leishmania donovani or HIV.


Vyšlo v časopise: : Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with. PLoS Pathog 11(8): e32767. doi:10.1371/journal.ppat.1005127
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005127

Souhrn

In this work we performed a comprehensive evaluation of the infective potential of Leptomonas seymouri, repeatedly isolated from kala-azar patients infected by Leishmania donovani in India and neighboring countries, and have tested the capacity of this monoxenous trypanosomatid to utilize the sand fly vectors permissive for Leishmania donovani. We concluded that despite several genetic adaptations it has developed, Leptomonas seymouri remains a predominantly monoxenous species not able to infect mammalian macrophages either alone or in co-infection with Leishmania. Under certain circumstances it is able to infect mammals, but probably only when the host is immunocompromised by infection with another pathogen, such as Leishmania donovani or HIV.


Zdroje

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