Extreme Divergence of Tropism for the Stem-Cell-Niche in the Testis

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Microbes evolve to infect structures favoring their transmission in host populations. A large fraction of insects are infected with Wolbachia bacteria. Usually Wolbachia are transmitted the same way we inherit our mitochondria, via the eggs from the mother. In fruit flies, to favor maternal transmission, Wolbachia infect the microenvironment containing the egg producing stem cells, called the “stem cell niche”. Targeting of the stem cell niche is evolutionary conserved in female fruit flies, observed in all Wolbachia strains analyzed to date. Remarkably, in males, we find many Wolbachia strains not infecting the stem cell niche present in the testis. We report a surprising diversity in stem cell niche infection in males, contrasting with extreme conservation in females. We further show that even closely related Wolbachia strains in D. melanogaster display rapidly evolving patterns of stem cell niche targeting in males. Understanding the molecular mechanisms driving these differences will identify sex specific features of stem cell niche biology. Because Wolbachia promote insect resistance against human diseases transmitted by mosquitos, Wolbachia are becoming a valuable tool in the control of several diseases, including Dengue and malaria. Knowledge emerging from this research will also provide novel tools towards Wolbachia based strategies of disease control.

Vyšlo v časopise: Extreme Divergence of Tropism for the Stem-Cell-Niche in the Testis. PLoS Pathog 10(12): e32767. doi:10.1371/journal.ppat.1004577
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004577

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