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Too Much Cleavage of Cyclin E Promotes Breast Tumorigenesis


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Vyšlo v časopise: Too Much Cleavage of Cyclin E Promotes Breast Tumorigenesis. PLoS Genet 8(3): e32767. doi:10.1371/journal.pgen.1002623
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002623

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Zdroje

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6. HarwellRMPorterDCDanesCKeyomarsiK 2000 Processing of cyclin E differs between normal and tumor breast cells. Cancer Res 60 481 489

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8. HarwellRMMullBBPorterDCKeyomarsiK 2004 Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. J Biol Chem 279 12695 12705

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10. AkliSZhengPJMultaniASWingateHFPathakS 2004 Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res 64 3198 3208

11. WingateHZhangNMcGarhenMJBedrosianIHarperJW 2005 The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27. J Biol Chem 280 15148 15157

12. AkliSVan PeltCSBuiTMultaniASChangS 2007 Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67 7212 7222

13. Bagheri-YarmandRBiernackaAHuntKKKeyomarsiK 2010 Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification. Cancer Res 70 5074 5084

14. ZhouYJXieYTGuJYanLGuanGX 2011 Overexpression of cyclin E isoforms correlates with poor prognosis in rectal cancer. Eur J Surg Oncol 37 1078 1084

15. CorinIDi GiacomoMCLastellaPBagnuloRGuantiG 2006 Tumor-specific hyperactive low-molecular-weight cyclin E isoforms detection and characterization in non-metastatic colorectal tumors. Cancer Biol Ther 5 198 203

16. DavidsonBSkredeMSilinsIShih IeMTropeCG 2007 Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma. Cancer 110 1264 1271

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18. DuongMTAkliSWeiCWingateHFLiuW 2012 LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients. PLoS Genet 8 e1002538 doi:10.1371/journal.pgen.1002538

19. AkliSVan PeltCSBuiTMeijerLKeyomarsiK 2011 Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. Cancer Res 71 3377 3386

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21. SpruckCSunDFieglHMarthCMueller-HolznerE 2006 Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer. Cancer Res 66 7355 7360

22. DelkNAHuntKKKeyomarsiK 2009 Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation. Cancer Res 69 2817 2825

23. JackmanMKubotaYden ElzenNHagtingAPinesJ 2002 Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm. Mol Biol Cell 13 1030 1045

24. CarusoJAHuntKKKeyomarsiK 2010 The neutrophil elastase inhibitor elafin triggers rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer. Cancer Res 70 7125 7136

Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


2012 Číslo 3
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