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Skin-Derived C-Terminal Filaggrin-2 Fragments Are -Directed Antimicrobials Targeting Bacterial Replication


Pseudomonas aeruginosa is able to cause severe infections that increasingly threaten patients with cystic fibrosis and burns. The emerging antibiotic resistance of those bacteria exigently necessitates the development of new effective drugs. Since healthy skin is unexpectedly resistant towards P. aeruginosa infections, it constitutes a promising source of new antimicrobials. We identified fragments of the insoluble skin protein filaggrin-2 as P. aeruginosa-bactericidal proteins that can be released by the action of P. aeruginosa from the outermost skin layer. Unlike many other antimicrobial proteins, filaggrin-2 fragments target bacterial replication, thus presenting a new mode of antibacterial action. Our findings could initiate the urgent development of newly designed antimicrobials and effectively tackle the challenges of Pseudomonas infections


Vyšlo v časopise: Skin-Derived C-Terminal Filaggrin-2 Fragments Are -Directed Antimicrobials Targeting Bacterial Replication. PLoS Pathog 11(9): e32767. doi:10.1371/journal.ppat.1005159
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005159

Souhrn

Pseudomonas aeruginosa is able to cause severe infections that increasingly threaten patients with cystic fibrosis and burns. The emerging antibiotic resistance of those bacteria exigently necessitates the development of new effective drugs. Since healthy skin is unexpectedly resistant towards P. aeruginosa infections, it constitutes a promising source of new antimicrobials. We identified fragments of the insoluble skin protein filaggrin-2 as P. aeruginosa-bactericidal proteins that can be released by the action of P. aeruginosa from the outermost skin layer. Unlike many other antimicrobial proteins, filaggrin-2 fragments target bacterial replication, thus presenting a new mode of antibacterial action. Our findings could initiate the urgent development of newly designed antimicrobials and effectively tackle the challenges of Pseudomonas infections


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