ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry

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The induction of antiviral innate immune signaling is a primary defense strategy employed by host cells to restrict virus infections. This system is triggered by the presence of ‘non-self’ components such as viral nucleic acids and culminates in the induction of type I interferons (IFNs). Type I IFNs themselves possess no direct antiviral activity and instead exert their potent antiviral effects via the induction of hundreds of interferon-stimulated genes (ISGs) that directly antagonize viruses at a variety of steps in their infectious cycles. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) as an ISG whose expression restricts the replication of dengue virus (DENV), which infects as many as 400 million people worldwide annually, at the stage of virion entry and/or trafficking. Our study thus not only identifies ADAP2 as a previously uncharacterized ISG, but also points to its role in the inhibition of DENV replication at the earliest stages of the DENV life cycle.

Vyšlo v časopise: ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. PLoS Pathog 11(9): e32767. doi:10.1371/journal.ppat.1005150
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005150

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