1. de CarvalhoLPS, FischerSM, MarreroJ, NathanC, EhrtS, et al. (2010) Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates. Chemistry & biology 17: 1122–1131.
2. DanielJ, MaamarH, DebC, SirakovaTD, KolattukudyPE (2011) Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophages. PLoS pathogens 7: e1002093.
3. Muñoz-ElíasEJ, McKinneyJD (2005) Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nature medicine 11: 638–644.
4. PandeyAK, SassettiCM (2008) Mycobacterial persistence requires the utilization of host cholesterol. Proceedings of the National Academy of Sciences 105: 4376–4380.
5. RohdeKH, VeigaDF, CaldwellS, BalázsiG, RussellDG (2012) Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. PLoS pathogens 8: e1002769.
6. RussellDG, BarryCE, FlynnJL (2010) Tuberculosis: what we don't know can, and does, hurt us. Science 328: 852–856.
7. RussellDG, CardonaP-J, KimM-J, AllainS, AltareF (2009) Foamy macrophages and the progression of the human tuberculosis granuloma. Nature immunology 10: 943–948.
8. RussellDG, VanderVenBC, LeeW, AbramovitchRB, KimM-j, et al. (2010) Mycobacterium tuberculosis Wears What It Eats. Cell host & microbe 8: 68–76.
9. SauerU (2006) Metabolic networks in motion: 13C-based flux analysis. Molecular systems biology 2: 62.
10. YuanJ, BennettBD, RabinowitzJD (2008) Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nature protocols 3: 1328–1340.
11. YuanJ, FowlerWU, KimballE, LuW, RabinowitzJD (2006) Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nature chemical biology 2: 529–530.
12. CuriR, NewsholmeP, Pithon-CuriT, Pires-de-MeloM, GarciaC, et al. (1999) Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils. Brazilian Journal of Medical and Biological Research 32: 15–21.
13. SinghV, JamwalS, JainR, VermaP, GokhaleR, et al. (2012) Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype. Cell host & microbe 12: 669–681.
14. IhrlundLS, HernlundE, KhanO, ShoshanMC (2008) 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Molecular oncology 2: 94–101.
15. PereiraDSA, El-BachaT, KyawN, Dos SantosR, Da-SilvaW, et al. (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1. Biochem J 417: 717–726.
16. Resat H, Petzold L, Pettigrew MF (2009) Kinetic modeling of biological systems. Computational Systems Biology:Springer. pp. 311–335.
17. KumarD, NathL, KamalMA, VarshneyA, JainA, et al. (2010) Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis. Cell 140: 731–743.
18. BarghouthiS, EverettK, SpeertDP (1995) Nonopsonic phagocytosis of Pseudomonas aeruginosa requires facilitated transport of D-glucose by macrophages. The Journal of Immunology 154: 3420–3428.
19. Ida-YonemochiH, NakatomiM, HaradaH, TakataH, BabaO, et al. (2012) Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars. Developmental biology 363: 52–61.
20. Rodríguez-EnríquezS, Marín-HernándezA, Gallardo-PérezJC, Moreno-SánchezR (2009) Kinetics of transport and phosphorylation of glucose in cancer cells. Journal of cellular physiology 221: 552–559.
21. SiessEA, Kientsch-EngelRI, WielandOH (1982) Role of free oxaloacetate in ketogenesis. European Journal of Biochemistry 121: 493–499.
22. SegalW, BlochH (1956) Biochemical differentiation of Mycobacterium tuberculosis grown in vivo and in vitro. Journal of bacteriology 72: 132.
23. LeeW, VanderVenBC, FaheyRJ, RussellDG (2013) Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. Journal of Biological Chemistry 288: 6788–6800.
24. Farese JrRV, WaltherTC (2009) Lipid droplets finally get a little RESPECT. Cell 139: 855–860.
25. D'AvilaH, MeloRC, ParreiraGG, Werneck-BarrosoE, Castro-Faria-NetoHC, et al. (2006) Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. The Journal of Immunology 176: 3087–3097.
26. PeyronP, VaubourgeixJ, PoquetY, LevillainF, BotanchC, et al. (2008) Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS pathogens 4: e1000204.
27. ThiamAR, Farese JrRV, WaltherTC (2013) The biophysics and cell biology of lipid droplets. Nature Reviews Molecular Cell Biology 14: 775–786.
28. LlaveriasG, LacasaD, ViñalsM, Vázquez-CarreraM, SánchezRM, et al. (2004) Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin. Biochemical pharmacology 68: 155–163.
29. GaoY, LinL-P, ZhuC-H, ChenY, HouY-T, et al. (2006) Research Paper Growth Arrest Induced by C75, A Fatty Acid Synthase Inhibitor, was Partially Modulated by p38 MAPK but Not by p53 In Human Hepatocellular Carcinoma. Cancer biology & therapy 5: 978–985.
30. KimMJ, WainwrightHC, LocketzM, BekkerLG, WaltherGB, et al. (2010) Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO molecular medicine 2: 258–274.
31. AronisA, MadarZ, TiroshO (2005) Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774. 2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. Free Radical Biology and Medicine 38: 1221–1230.
32. AronisA, MadarZ, TiroshO (2008) Lipotoxic effects of triacylglycerols in J774. 2 macrophages. Nutrition 24: 167–176.
33. BrasaemleDL, RubinB, HartenIA, Gruia-GrayJ, KimmelAR, et al. (2000) Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. Journal of Biological Chemistry 275: 38486–38493.
34. HalestrapAP (1978) Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier. Biochem J 172: 377–387.
35. HerzigS, RaemyE, MontessuitS, VeutheyJ-L, ZamboniN, et al. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337: 93–96.
36. BeharSM, DivangahiM, RemoldHG (2010) Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? Nature Reviews Microbiology 8: 668–674.
37. FratazziC, ArbeitRD, CariniC, RemoldHG (1997) Programmed cell death of Mycobacterium avium serovar 4-infected human macrophages prevents the mycobacteria from spreading and induces mycobacterial growth inhibition by freshly added, uninfected macrophages. The Journal of Immunology 158: 4320–4327.
38. LeeJ, HartmanM, KornfeldH (2009) Macrophage apoptosis in tuberculosis. Yonsei medical journal 50: 1–11.
39. LópezM, SlyLM, LuuY, YoungD, CooperH, et al. (2003) The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2. The Journal of Immunology 170: 2409–2416.
40. OddoM, RennoT, AttingerA, BakkerT, MacDonaldHR, et al. (1998) Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis. The Journal of Immunology 160: 5448–5454.
41. LeeJ, RepasyT, PapavinasasundaramK, SassettiC, KornfeldH (2011) Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PloS one 6: e18367.
42. RamakrishnanL (2012) Revisiting the role of the granuloma in tuberculosis. Nature Reviews Immunology 12: 352–366.
43. ThiEP, LambertzU, ReinerNE (2012) Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle. PLoS pathogens 8: e1002551.
44. BakerMA, HarriesAD, JeonCY, HartJE, KapurA, et al. (2011) The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC medicine 9: 81.
45. DooleyKE, ChaissonRE (2009) Tuberculosis and diabetes mellitus: convergence of two epidemics. The Lancet infectious diseases 9: 737–746.
46. JeonCY, MurrayMB (2008) Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS medicine 5: e152.
47. MartensGW, ArikanMC, LeeJ, RenF, GreinerD, et al. (2007) Tuberculosis susceptibility of diabetic mice. American journal of respiratory cell and molecular biology 37: 518.
48. VallerskogT, MartensGW, KornfeldH (2010) Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. The Journal of Immunology 184: 6275–6282.
49. XavierMN, WinterMG, SpeesAM, den HartighAB, NguyenK, et al. (2013) PPARγ-Mediated Increase in Glucose Availability Sustains Chronic Brucella abortus Infection in Alternatively Activated Macrophages. Cell host & microbe 14: 159–170.
50. PezzuloAA, GutiérrezJ, DuschnerKS, McConnellKS, TaftPJ, et al. (2011) Glucose depletion in the airway surface liquid is essential for sterility of the airways. PloS one 6: e16166.
51. LinJ, LiH, YangM, RenJ, HuangZ, et al. (2013) A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell reports 3: 200–210.
52. MooreKJ, TabasI (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341–355.
53. RotaS, RotaS (2005) c yb o osis acterium tubercul M. Acta Med Okayama 59: 247–251.
54. SheuJ-J, ChiouH-Y, KangJ-H, ChenY-H, LinH-C (2010) Tuberculosis and the Risk of Ischemic Stroke A 3-Year Follow-Up Study. Stroke 41: 244–249.
55. TabasI (1997) Free cholesterol-induced cytotoxicity: a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions. Trends in cardiovascular medicine 7: 256–263.
56. MungerJ, BennettBD, ParikhA, FengX-J, McArdleJ, et al. (2008) Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nature biotechnology 26: 1179–1186.
57. GuayC, MadirajuSM, AumaisA, JolyÉ, PrentkiM (2007) A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. Journal of Biological Chemistry 282: 35657–35665.
58. LiJJ, WangH, TinoJA, RoblJA, HerpinTF, et al. (2007) 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorganic & medicinal chemistry letters 17: 3208–3211.
59. HuangC, KuoW, HuangY, LeeT, YuL (2013) Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. Cell death & disease 4: e622.