1. CrottyS (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29: 621–663.
2. HaynesNM, AllenCD, LesleyR, AnselKM, KilleenN, et al. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 179: 5099–5108.
3. MaCS, SuryaniS, AveryDT, ChanA, NananR, et al. (2009) Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol 87: 590–600.
4. PetrovasC, YamamotoT, GernerMY, BoswellKL, WlokaK, et al. (2012) CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest 122: 3281–3294.
5. KimCH, LimHW, KimJR, RottL, HillsamerP, et al. (2004) Unique gene expression program of human germinal center T helper cells. Blood 104: 1952–1960.
6. YuD, VinuesaCG (2010) The elusive identity of T follicular helper cells. Trends Immunol 31: 377–383.
7. FaheyLM, WilsonEB, ElsaesserH, FistonichCD, McGavernDB, et al. (2011) Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med 208: 987–999.
8. Glatman ZaretskyA, TaylorJJ, KingIL, MarshallFA, MohrsM, et al. (2009) T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 206: 991–999.
9. NurievaRI, ChungY, HwangD, YangXO, KangHS, et al. (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138–149.
10. NurievaRI, ChungY, MartinezGJ, YangXO, TanakaS, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325: 1001–1005.
11. YuD, RaoS, TsaiLM, LeeSK, HeY, et al. (2009) The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31: 457–468.
12. LuthjeK, KalliesA, ShimohakamadaY, BelzGT, LightA, et al. (2012) The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 13: 491–498.
13. PepperM, JenkinsMK (2011) Origins of CD4(+) effector and central memory T cells. Nat Immunol 12: 467–471.
14. MoritaR, SchmittN, BentebibelSE, RanganathanR, BourderyL, et al. (2011) Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 34: 108–121.
15. LindqvistM, van LunzenJ, SoghoianDZ, KuhlBD, RanasingheS, et al. (2012) Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest 122: 3271–3280.
16. PallikkuthS, ParmigianiA, SilvaSY, GeorgeVK, FischlM, et al. (2012) Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine. Blood 120: 985–993.
17. ChevalierN, JarrossayD, HoE, AveryDT, MaCS, et al. (2011) CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol 186: 5556–5568.
18. BreitfeldD, OhlL, KremmerE, EllwartJ, SallustoF, et al. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545–1552.
19. MikellI, SatherDN, KalamsSA, AltfeldM, AlterG, et al. (2011) Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog 7: e1001251.
20. Doria-RoseNA, KleinRM, DanielsMG, O'DellS, NasonM, et al. (2010) Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables. J Virol 84: 1631–1636.
21. HaleJS, YoungbloodB, LatnerDR, MohammedAU, YeL, et al. (2013) Distinct Memory CD4(+) T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection. Immunity 38: 805–817.
22. LintermanMA, BeatonL, YuD, RamiscalRR, SrivastavaM, et al. (2010) IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 207: 353–363.
23. Le GallouS, CaronG, DelaloyC, RossilleD, TarteK, et al. (2012) IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling. J Immunol 189: 161–173.
24. DoreauA, BelotA, BastidJ, RicheB, Trescol-BiemontMC, et al. (2009) Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol 10: 778–785.
25. BentebibelSE, SchmittN, BanchereauJ, UenoH (2011) Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc Natl Acad Sci U S A 108: E488–497.
26. ShulmanZ, GitlinAD, TargS, JankovicM, PasqualG, et al. (2013) T follicular helper cell dynamics in germinal centers. Science 341: 673–677.
27. LocciM, Havenar-DaughtonC, LandaisE, WuJ, KroenkeMA, et al. (2013) Human Circulating PD-1CXCR3CXCR5 Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses. Immunity 39: 758–769.
28. HaleJS, YoungbloodB, LatnerDR, MohammedAU, YeL, et al. (2013) Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity 38: 805–817.
29. MalaspinaA, MoirS, DiPotoAC, HoJ, WangW, et al. (2008) CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals. J Immunol 181: 1199–1206.
30. HarkerJA, LewisGM, MackL, ZunigaEI (2011) Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334: 825–829.
31. CagigiA, MowafiF, Phuong DangLV, Tenner-RaczK, AtlasA, et al. (2008) Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood 112: 4401–4410.
32. WidneyDP, BreenEC, BoscardinWJ, KitchenSG, AlcantarJM, et al. (2005) Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. J Interferon Cytokine Res 25: 702–706.
33. SandlerNG, WandH, RoqueA, LawM, NasonMC, et al. (2011) Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 203: 780–790.
34. HeB, QiaoX, KlassePJ, ChiuA, ChadburnA, et al. (2006) HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J Immunol 176: 3931–3941.
35. BentebibelSE, LopezS, ObermoserG, SchmittN, MuellerC, et al. (2013) Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination. Sci Transl Med 5: 176ra132.
36. SpensieriF, BorgogniE, ZeddaL, BardelliM, BuricchiF, et al. (2013) Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses. Proc Natl Acad Sci U S A 110: 14330–14335.
37. HeJ, TsaiLM, LeongYA, HuX, MaCS, et al. (2013) Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure. Immunity 39: 770–781.
38. BirxDL, Loomis-PriceLD, AronsonN, BrundageJ, DavisC, et al. (2000) Efficacy testing of recombinant human immunodeficiency virus (HIV) gp160 as a therapeutic vaccine in early-stage HIV-1-infected volunteers. rgp160 Phase II Vaccine Investigators. J Infect Dis 181: 881–889.
39. HaubrichRH, RiddlerSA, DiRienzoAG, KomarowL, PowderlyWG, et al. (2009) Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS 23: 1109–1118.
40. RiddlerSA, HaubrichR, DiRienzoAG, PeeplesL, PowderlyWG, et al. (2008) Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med 358: 2095–2106.
41. CooperA, GarciaM, PetrovasC, YamamotoT, KoupRA, et al. (2013) HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature 498: 376–379.