Host Defense via Symbiosis in

1. CirimotichCM, DongY, ClaytonAM, SandifordSL, Souza-NetoJA, et al. (2011) Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science 332 : 855–858.

2. MateosM, CastrezanaSJ, NankivellBJ, EstesAM, MarkowTA, et al. (2006) Heritable endosymbionts of Drosophila. Genetics 174 : 363–376.

3. WerrenJ, BaldoL, ClarkM (2008) Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiology 6 : 741–751.

4. AnbutsuH, FukatsuT (2011) Spiroplasma as a model insect endosymbiont. Env Microb Reports 3 : 144–153.

5. ZugR, HammersteinP (2012) Still a host of hosts for Wolbachia: analysis of recent data suggests that 40% of terrestrial arthropod species are infected. PLoS ONE 7: e38544 doi:10.1371/journal.pone.0038544

6. HosokawaT, KogaR, KikuchiY, MengX-Y, FukatsuT (2010) Wolbachia as a bacteriocyte-associated nutritional mutualist. Proc Natl Acad Sci U S A 107 : 769–774.

7. TeixeiraL, FerreiraÁ, AshburnerM (2008) The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster. PLoS Biol 6: e1000002 doi:10.1371/journal.pbio.1000002

8. HedgesLM, BrownlieJC, O'NeillSL, JohnsonKN (2008) Wolbachia and virus protection in insects. Science 322 : 702.

9. OsborneSE, LeongYS, O'NeillSL, JohnsonKN (2009) Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans. PLoS Pathog 5: e1000656 doi:10.1371/journal.ppat.1000656

10. UncklessRL, JaenikeJ (2011) Maintenace of a male-killing Wolbachia in Drosophila by male-killing dependent and male-killing independent mechanisms. Evolution 66 : 678–690.

11. GlaserRL, MeolaMA (2010) The native Wolbachia endosymbionts of Drosophila melanogaster and Culex quinquefasciatus increase host resitance to West Nile Virus infection. PLoS ONE 5: e11977 doi:10.1371/journal.pone.0011977

12. WongZS, HedgesLM, BrownlieJC, JohnsonKN (2012) Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila. PLoS ONE 6: e25430 doi:10.1371/journal.pone.0025430

13. YeYH, WoolfitM, RancèsE, O'NeillSL, McGrawEA (2013) Wolbachia-associated bacterial protection in the mosquito Aedes aegypti. PLoS Negl Trop Dis 7: e2362 doi:10.1371/journal.pntd.0002362

14. LongdonB, FabianDK, HurstGD, JigginsFM (2012) Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection. BMC Microbiol 122(s1): S8.

15. MoreiraLA, Iturbe-OrmaetxeI, JefferyJA, LuG, PykeAT, et al. (2009) A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium. Cell 139 : 1268–1278.

16. BianG, XuY, LuP, XieY, XiZ (2010) The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti. PLoS Pathog 6: e1000833 doi:10.1371/journal.ppat.1000833

17. KambrisZ, CookPE, PhucHK, SinkinsSP (2009) Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science 326 : 134–136.

18. HughesGL, KogaR, XueP, FukatsuT, RasgonJL (2011) Wolbachia infections are virulent and inhibit the human malaria parasite Plasmodium falciparum in Anopheles gambiae. PLoS Pathog 7: e1002043 doi:10.1371/journal.ppat.1002043

19. BianG, JoshiD, DongY, LuP, ZhouG, et al. (2013) Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection. Science 340 : 748–751.

20. PanX, ZhouG, WuJ, BianG (2012) Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A 109: E23–31.

21. RancèsE, YeYH, WoolfitM, McGrawEA, O'NeillSL (2012) The relative importance of innate immune priming in Wolbachia-mediated dengue interference. PLoS Pathog 8: e1002548 doi:10.1371/journal.ppat.1002548

22. CaragataEP, RancèsE, HedgesLM, GoftonAW, JohnsonKN, et al. (2013) Dietary cholesterol modulates pathogen blocking by Wolbachia. PLoS Pathog 9: e1003459 doi:10.1371/journal.ppat.1003459

23. ZhangG, HussainM, O'NeillSL, AsgariS (2013) Wolbachia uses a host microRNA to regulate transcripts of a methyltransferase, contributing to dengue virus inhibition in Aedes aegypti. Proc Natl Acad Sci U S A 110 : 10276–10281.

24. HoffmannAA, MontgomeryBL, PopoviciJ, Iturbe-OrmaetxeI, JohnsonPH, et al. (2011) Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476 : 454–457.

25. WattsT, HaselkornTS, MoranNA, MarkowTA (2009) Variable incidence of Spiroplasma infections in natural populations of Drosophila species. PLoS ONE 4: e5703 doi:10.1371/journal.pone.0005703

26. XieJ, VilchezI, MateosM (2010) Spiroplasma bacteria enhance survival of Drosophila hydei attacked by the parasitic wasp Leptopilina heterotoma. PLoS ONE 5: e12149 doi:10.1371/journal.pone.0012149

27. JaenikeJ, UncklessR, CockburnSN, BoelioLM, PerlmanSJ (2010) Adaptation via symbiosis: recent spread of a Drosophila defensive symbiont. Science 329 : 212–215.

28. ŁukasikP, van AschM, GuoH, FerrariJ, GodfrayHCJ (2013) Unrelated facultative endosymbionts protect aphids against a fungal pathogen. Ecol Lett 16 : 214–218.

29. CockburnSN, HaselkornTS, HamiltonPT, LandzbergE, JaenikeJ, et al. (2013) Dynamics of the continent-wide spread of a Drosophila defensive symbiont. Ecol Lett 16 : 609–616.

30. HutchenceKJ, FischerB, PatersonS, HurstGDD (2011) How do insects react to novel inherited symbionts? A microarray analysis of Drosophila melanogaster response to the presence of natural and introduced Spiroplasma. Mol Ecol 20 : 950–958.

31. HerrenJK, LemaitreB (2011) Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster. Cell Microbiol 13 : 1385–1396.

32. MoranNA, DegnanPH, SantosSR, DunbarHE, OchmanH (2005) The players in a mutualistic symbiosis: Insects, bacteria, viruses, and virulence genes. Proc Natl Acad Sci U S A 102 : 16919–16926.

33. TelferS, LambinX, BirtlesR, BeldomenicoP, BurtheS, et al. (2010) Species interactions in a parasite community drive infection risk in a wildlife population. Science 330 : 243–246.

34. KochH, Schmid-HempelP (2011) Socially transmitted gut microbiota protect bumble bees against an intestinal parasite. Proc Natl Acad Sci U S A 108 : 19288–19292.