#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study


In a matched case-control-study among patients in Ontario, Canada treated with opioid painkillers, Tara Gomes and colleagues investigate whether co-prescription of gabapentin is associated with an increased risk of accidental opioid-related death.


Vyšlo v časopise: Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. PLoS Med 14(10): e32767. doi:10.1371/journal.pmed.1002396
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002396

Souhrn

In a matched case-control-study among patients in Ontario, Canada treated with opioid painkillers, Tara Gomes and colleagues investigate whether co-prescription of gabapentin is associated with an increased risk of accidental opioid-related death.


Zdroje

1. US Centers for Disease Control and Prevention. Prescription opioid overdose data. Atlanta: US Centers for Disease Control and Prevention; 2017 [cited 2017 Sep 5]. Available from: http://www.cdc.gov/drugoverdose/data/overdose.html.

2. Park TW, Saitz R, Ganoczy D, Ilgen MA, Bohnert AS. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ. 2015;350:h2698. doi: 10.1136/bmj.h2698 26063215

3. US Food and Drug Administration. New safety measures announced for opioid analgesics, prescription opioid cough products, and benzodiazepines. Silver Spring (Maryland): US Food and Drug Administration; 2016 Aug 31 [cited 2017 Aug 30]. Available from: http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm518110.htm.

4. Kaplovitch E, Gomes T, Camacho X, Dhalla IA, Mamdani MM, Juurlink DN. Sex differences in dose escalation and overdose death during chronic opioid therapy: a population-based cohort study. PLoS ONE. 2015;10(8):e0134550. doi: 10.1371/journal.pone.0134550 26291716

5. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010;49(10):661–9. doi: 10.2165/11536200-000000000-00000 20818832

6. Canadian Agency for Drugs and Technologies in Health. Gabapentin for adults with neuropathic pain: a review of the clinical efficacy and safety. Toronto: Canadian Agency for Drugs and Technologies in Health; 2015 Apr 14 [cited 2017 Aug 30]. Available from: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0078634/pdf/PubMedHealth_PMH0078634.pdf.

7. Zaccara G, Gangemi PF, Cincotta M. Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure. 2008;17(5):405–21. doi: 10.1016/j.seizure.2007.12.003 18262442

8. Ongley D, Hayward AK, Allan C. Severe respiratory depression associated with perioperative opioid-sparing gabapentin use. Anaesth Intensive Care. 2014;42(1):136–7. 24471675

9. Batoon SB, Vela AT, Dave D, Wahid Z, Conetta R, Iakovou C, et al. Recurrent hypoventilation and respiratory failure during gabapentin therapy. J Am Geriatr Soc. 2001;49(4):498. 11347805

10. Weingarten TN, Jacob AK, Njathi CW, Wilson GA, Sprung J. Multimodal analgesic protocol and postanesthesia respiratory depression during phase i recovery after total joint arthroplasty. Reg Anesth Pain Med. 2015;40(4):330–6. doi: 10.1097/AAP.0000000000000257 25967650

11. Health Canada. Summary safety review—gabapentin—assessing the potential risk of serious breathing problems. Ottawa: Health Canada; 2016 Sep 16 [cited 2017 Aug 30]. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/summary-safety-review-gabapentin-assessing-potential-risk-serious-breathing.html.

12. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg. 2000;91(1):185–91. 10866910

13. McLean MJ. Clinical pharmacokinetics of gabapentin. Neurology. 1994;44(6 Suppl 5):S17–22.

14. Mack A. Examination of the evidence for off-label use of gabapentin. J Manag Care Pharm. 2003;9(6):559–68. doi: 10.18553/jmcp.2003.9.6.559 14664664

15. Gomes T, Juurlink DN, Dhalla IA, Mailis-Gagnon A, Paterson JM, Mamdani MM. Trends in opioid use and dosing among socio-economically disadvantaged patients. Open Med. 2011;5(1):e13–22. 22046214

16. Ruscitto A, Smith BH, Guthrie B. Changes in opioid and other analgesic use 1995–2010: repeated cross-sectional analysis of dispensed prescribing for a large geographical population in Scotland. Eur J Pain. 2015;19(1):59–66. doi: 10.1002/ejp.520 24807782

17. Smith RV, Havens JR, Walsh SL. Gabapentin misuse, abuse and diversion: a systematic review. Addiction. 2016;111(7):1160–74. doi: 10.1111/add.13324 27265421

18. Hux JE, Ivis F, Flintoft V, Bica A. Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm. Diabetes Care. 2002;25(3):512–6. 11874939

19. Fleet JL, Dixon SN, Shariff SZ, Quinn RR, Nash DM, Harel Z, et al. Detecting chronic kidney disease in population-based administrative databases using an algorithm of hospital encounter and physician claim codes. BMC Nephrol. 2013;14:81. doi: 10.1186/1471-2369-14-81 23560464

20. Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. CMAJ. 2009;181(12):891–6. doi: 10.1503/cmaj.090784 19969578

21. Gladstone E, Smolina K, Morgan SG, Fernandes KA, Martins D, Gomes T. Sensitivity and specificity of administrative mortality data for identifying prescription opioid-related deaths. CMAJ. 2016;188(4):E67–72. doi: 10.1503/cmaj.150349 26622006

22. Gomes T, Mamdani MM, Dhalla IA, Paterson JM, Juurlink DN. Opioid dose and drug-related mortality in patients with nonmalignant pain. Arch Intern Med. 2011;171(7):686–91. doi: 10.1001/archinternmed.2011.117 21482846

23. Gomes T, Mamdani MM, Dhalla IA, Cornish S, Paterson JM, Juurlink DN. The burden of premature opioid-related mortality. Addiction. 2014;109(9):1482–8. doi: 10.1111/add.12598 25041316

24. Gomes T, Redelmeier DA, Juurlink DN, Dhalla IA, Camacho X, Mamdani MM. Opioid dose and risk of road trauma in Canada: a population-based study. JAMA Intern Med. 2013;173(3):196–201. doi: 10.1001/2013.jamainternmed.733 23318919

25. National Opioid Use Guideline Group. Canadian guideline for safe and effective use of opioids for chronic non-cancer pain. Hamilton (Ontario): Michael G. DeGroote National Pain Centre; 2010 [cited 2017 Aug 30]. Available from: http://nationalpaincentre.mcmaster.ca/opioid/.

26. Mamdani M, Sykora K, Li P, Normand SL, Streiner DL, Austin PC, et al. Reader’s guide to critical appraisal of cohort studies: 2. Assessing potential for confounding. BMJ. 2005;330(7497):960–2. doi: 10.1136/bmj.330.7497.960 15845982

27. Benchimol EI, Smeeth L, Guttmann A, Harron K, Hemkens LG, Moher D, et al. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLOS Med. 2015;12(10):e1001885. doi: 10.1371/journal.pmed.1001885 26440803

28. Eipe N, Penning J. Postoperative respiratory depression with pregabalin: a case series and a preoperative decision algorithm. Pain Res Manag. 2011;16(5):353–6. 22059207

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2017 Číslo 10
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Získaná hemofilie - Povědomí o nemoci a její diagnostika
nový kurz

Eozinofilní granulomatóza s polyangiitidou
Autori: doc. MUDr. Martina Doubková, Ph.D.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#