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Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Retina


Establishing neural circuits during brain development relies on the ability for neurons to find their appropriate targets, a task that depends on recognition molecules whose expression must be tightly controlled. Very little is known of the factors that control the expression of these molecules. Here we have used the genetically amenable fly retina to address this issue. We identify Orthodenticle, a protein involved in mammalian brain development, as a main component of a new genetic cascade controlling the expression of recognition molecules that govern the wiring of the fly retina. Our work raises the issue that Orthodenticle might play a similar role in mammals. It also sheds new light on the genetic basis for wiring a model neural circuit during development.


Vyšlo v časopise: Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Retina. PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005303
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005303

Souhrn

Establishing neural circuits during brain development relies on the ability for neurons to find their appropriate targets, a task that depends on recognition molecules whose expression must be tightly controlled. Very little is known of the factors that control the expression of these molecules. Here we have used the genetically amenable fly retina to address this issue. We identify Orthodenticle, a protein involved in mammalian brain development, as a main component of a new genetic cascade controlling the expression of recognition molecules that govern the wiring of the fly retina. Our work raises the issue that Orthodenticle might play a similar role in mammals. It also sheds new light on the genetic basis for wiring a model neural circuit during development.


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