Interplay of the Serine/Threonine-Kinase StkP and the Paralogs DivIVA and GpsB in Pneumococcal Cell Elongation and Division

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Over the last decade, bacterial genomics have revealed the presence of eukaryotic-type serine/threonine protein kinases (STKPs) in many bacteria. However, their role and mode of action is still elusive. Recent studies have suggested that STKPs could play an important role in regulating cell division of some bacterial species but the underlying regulatory mechanisms are largely unknown. Considering that much remains to be discovered about the mechanisms by which the cell division machinery is assembled at the cell center and how the diversity of bacterial cell shapes is achieved and maintained, studying the role of STKPs represents a promising approach to decipher the inner workings of bacterial cell division. In this article, we show that the ser/thr-kinase StkP and the two cell division paralogs GpsB and DivIVA of Streptococcus pneumoniae (the pneumococcus) work together to finely tune peptidoglycan synthesis and achieve proper cell shape and division. We discuss the likelihood that similar mechanisms occur in other bacteria requiring protein-kinases for the cell division process. We propose that the interplay between protein-kinases and cell-division proteins like GpsB or DivIVA is of crucial importance to satisfy the modes of cell division and the cell shape displayed by streptococci and other bacteria.

Vyšlo v časopise: Interplay of the Serine/Threonine-Kinase StkP and the Paralogs DivIVA and GpsB in Pneumococcal Cell Elongation and Division. PLoS Genet 10(4): e32767. doi:10.1371/journal.pgen.1004275
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004275

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