-
Články
- Časopisy
- Kurzy
- Témy
- Kongresy
- Videa
- Podcasty
A Case for Two-Component Signaling Systems As Antifungal Drug Targets
article has not abstract
Vyšlo v časopise: A Case for Two-Component Signaling Systems As Antifungal Drug Targets. PLoS Pathog 11(2): e32767. doi:10.1371/journal.ppat.1004632
Kategorie: Pearls
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004632Souhrn
article has not abstract
Zdroje
1. Pappas PG (2013) Lessons learned in the multistate fungal infection outbreak in the United States. Curr Opin Infect Dis 26 : 545–550. doi: 10.1097/QCO.0000000000000013 24152763
2. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, et al. (2012) Hidden killers: human fungal infections. Sci Transl Med 4 : 165rv113. doi: 10.1126/scitranslmed.3004404 23253612
3. Hof H (2010) Mycoses in the elderly. Eur J Clin Microbiol Infect Dis 29 : 5–13. doi: 10.1007/s10096-009-0822-5 19911208
4. Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20 : 133–163. 17223626
5. Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, et al. (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34 : 7–14. 11731939
6. Pfaller MA, Castanheira M, Messer SA, Moet GJ, Jones RN (2010) Variation in Candida spp. distribution and antifungal resistance rates among bloodstream infection isolates by patient age: report from the SENTRY Antimicrobial Surveillance Program (2008–2009). Diagn Microbiol Infect Dis 68 : 278–283. doi: 10.1016/j.diagmicrobio.2010.06.015 20846808
7. Wenzel RP (1995) Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis 20 : 1531–1534. 7548504
8. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, et al. (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39 : 309–317. 15306996
9. Perlin DS (2014) Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management. Drugs 74 : 1573–1585. doi: 10.1007/s40265-014-0286-5 25255923
10. Clemons KV, Miller TK, Selitrennikoff CP, Stevens DA (2002) fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. Med Mycol 40 : 259–262. 12146755
11. Calera JA, Calderone R (1999) Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiology 145 (Pt 6): 1431–1442.
12. Yamada-Okabe T, Mio T, Ono N, Kashima Y, Matsui M, et al. (1999) Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. J Bacteriol 181 : 7243–7247. 10572127
13. Desai C, Mavrianos J, Chauhan N (2011) Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence. Eukaryot Cell 10 : 1370–1374. doi: 10.1128/EC.05188-11 21841121
14. Bahn YS, Kojima K, Cox GM, Heitman J (2006) A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell 17 : 3122–3135. 16672377
15. Nemecek JC, Wuthrich M, Klein BS (2006) Global control of dimorphism and virulence in fungi. Science 312 : 583–588. 16645097
16. Mascher T, Helmann JD, Unden G (2006) Stimulus perception in bacterial signal-transducing histidine kinases. Microbiol Mol Biol Rev 70 : 910–938. 17158704
17. Fassler JS, West AH (2013) Histidine phosphotransfer proteins in fungal two-component signal transduction pathways. Eukaryot Cell 12 : 1052–1060. doi: 10.1128/EC.00083-13 23771905
18. Catlett NL, Yoder OC, Turgeon BG (2003) Whole-genome analysis of two-component signal transduction genes in fungal pathogens. Eukaryot Cell 2 : 1151–1161. 14665450
19. Chauhan N, Latge JP, Calderone R (2006) Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat Rev Microbiol 4 : 435–444. 16710324
20. Kurosu M, Begari E (2010) Bacterial Protein Kinase Inhibitors. Drug Development Research 71 : 168–187.
21. Kee JM, Muir TW (2012) Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. ACS Chem Biol 7 : 44–51. doi: 10.1021/cb200445w 22148577
22. Kee JM, Oslund RC, Perlman DH, Muir TW (2013) A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat Chem Biol 9 : 416–421. doi: 10.1038/nchembio.1259 23708076
23. Wilke KE, Francis S, Carlson EE (2012) Activity-based probe for histidine kinase signaling. J Am Chem Soc 134 : 9150–9153. doi: 10.1021/ja3041702 22606938
24. Tebbets B, Stewart D, Lawry S, Nett J, Nantel A, et al. (2012) Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One 7: e36021. doi: 10.1371/journal.pone.0036021 22574132
25. Okada A, Gotoh Y, Watanabe T, Furuta E, Yamamoto K, et al. (2007) Targeting two-component signal transduction: a novel drug discovery system. Methods Enzymol 422 : 386–395. 17628150
26. Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, et al. (2007) Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans. PLoS Pathog 3: e92. 17604452
27. Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, et al. (2009) Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot Cell 8 : 1197–1217. doi: 10.1128/EC.00120-09 19542307
28. Kruppa M, Goins T, Cutler JE, Lowman D, Williams D, et al. (2003) The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis. FEMS Yeast Res 3 : 289–299. 12689636
29. Li S, Dean S, Li Z, Horecka J, Deschenes RJ, et al. (2002) The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol Biol Cell 13 : 412–424. 11854400
30. Du C, Sarfati J, Latge JP, Calderone R (2006) The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus. Med Mycol 44 : 211–218. 16702099
31. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, et al. (2013) NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. PLoS One 8: e80881. doi: 10.1371/journal.pone.0080881 24312504
32. Bernhardt J, Herman D, Sheridan M, Calderone R (2001) Adherence and invasion studies of Candida albicans strains, using in vitro models of esophageal candidiasis. J Infect Dis 184 : 1170–1175. 11598840
33. Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, et al. (2004) The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryot Cell 3 : 1062–1065. 15302838
34. Torosantucci A, Chiani P, De Bernardis F, Cassone A, Calera JA, et al. (2002) Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro. Infect Immun 70 : 985–987. 11796636
35. Srikantha T, Tsai L, Daniels K, Enger L, Highley K, et al. (1998) The two-component hybrid kinase regulator CaNIK1 of Candida albicans. Microbiology 144 (Pt 10): 2715–2729. 9802013
36. Mavrianos J, Berkow EL, Desai C, Pandey A, Batish M, et al. (2013) Mitochondrial two-component signaling systems in Candida albicans. Eukaryot Cell 12 : 913–922. doi: 10.1128/EC.00048-13 23584995
37. Calera JA, Zhao XJ, Calderone R (2000) Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans. Infect Immun 68 : 518–525. 10639412
38. Chauhan N, Inglis D, Roman E, Pla J, Li D, et al. (2003) Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell 2 : 1018–1024. 14555484
39. Li D, Bernhardt J, Calderone R (2002) Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect Immun 70 : 1558–1565. 11854244
40. Singh P, Chauhan N, Ghosh A, Dixon F, Calderone R (2004) SKN7 of Candida albicans: mutant construction and phenotype analysis. Infect Immun 72 : 2390–2394. 15039366
41. Lee JW, Ko YJ, Kim SY, Bahn YS (2011) Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans. Eukaryot Cell 10 : 998–1002. doi: 10.1128/EC.05124-11 21642509
42. Wormley FL Jr., Heinrich G, Miller JL, Perfect JR, Cox GM (2005) Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Infect Immun 73 : 5022–5030. 16041017
Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium
Článek 2014 Reviewer Thank YouČlánek Characterization of Metabolically Quiescent Parasites in Murine Lesions Using Heavy Water LabelingČlánek High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers
Článok vyšiel v časopisePLOS Pathogens
Najčítanejšie tento týždeň
2015 Číslo 2- Parazitičtí červi v terapii Crohnovy choroby a dalších zánětlivých autoimunitních onemocnění
- Očkování proti virové hemoragické horečce Ebola experimentální vakcínou rVSVDG-ZEBOV-GP
- Koronavirus hýbe světem: Víte jak se chránit a jak postupovat v případě podezření?
-
Všetky články tohto čísla
- 2014 Reviewer Thank You
- A Case for Two-Component Signaling Systems As Antifungal Drug Targets
- Prions—Not Your Immunologist’s Pathogen
- Telomeric ORFS in : Does Mediator Tail Wag the Yeast?
- Livestock-Associated : The United States Experience
- The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Infection
- The Intracellular Bacterium Uses Parasitoid Wasps as Phoretic Vectors for Efficient Horizontal Transmission
- CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue
- Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing
- CXCL9 Contributes to Antimicrobial Protection of the Gut during Infection Independent of Chemokine-Receptor Signaling
- Mitigation of Prion Infectivity and Conversion Capacity by a Simulated Natural Process—Repeated Cycles of Drying and Wetting
- Approaches Reveal a Key Role for DCs in CD4+ T Cell Activation and Parasite Clearance during the Acute Phase of Experimental Blood-Stage Malaria
- Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Invasion of Erythrocytes
- Crystal Structures of the Carboxyl cGMP Binding Domain of the cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress
- Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
- Characterization of Metabolically Quiescent Parasites in Murine Lesions Using Heavy Water Labeling
- A Working Model of How Noroviruses Infect the Intestine
- CD44 Plays a Functional Role in -induced Epithelial Cell Proliferation
- Novel Inhibitors of Cholesterol Degradation in Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment
- G-Quadruplexes in Pathogens: A Common Route to Virulence Control?
- A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of
- Manipulating Adenovirus Hexon Hypervariable Loops Dictates Immune Neutralisation and Coagulation Factor X-dependent Cell Interaction and
- The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice
- Lymph-Node Resident CD8α Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8 T Cell Responses
- Coordinated Function of Cellular DEAD-Box Helicases in Suppression of Viral RNA Recombination and Maintenance of Viral Genome Integrity
- IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells
- Evasion of Autophagy and Intracellular Killing by Human Myeloid Dendritic Cells Involves DC-SIGN-TLR2 Crosstalk
- CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection
- Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice
- Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells
- Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites
- Disruption of an Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice
- Recognition of Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps
- Essential Domains of Invasins Utilized to Infect Mammalian Host Cells
- High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers
- Yeast Prions: Proteins Templating Conformation and an Anti-prion System
- A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles
- A Wild Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite
- Control of Murine Cytomegalovirus Infection by γδ T Cells
- Dimorphism in Fungal Pathogens of Mammals, Plants, and Insects
- Recognition and Activation Domains Contribute to Allele-Specific Responses of an Arabidopsis NLR Receptor to an Oomycete Effector Protein
- Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection
- Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism
- Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways
- Evolution of Genome Size and Complexity in the
- Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in
- IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells
- Identification of Effective Subdominant Anti-HIV-1 CD8+ T Cells Within Entire Post-infection and Post-vaccination Immune Responses
- Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation
- ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes
- Cytoplasmic Actin Is an Extracellular Insect Immune Factor which Is Secreted upon Immune Challenge and Mediates Phagocytosis and Direct Killing of Bacteria, and Is a Antagonist
- A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates CagA Epithelial Cell Interactions
- Within-host Competition Does Not Select for Virulence in Malaria Parasites; Studies with
- A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in
- Cytosolic Access of : Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence
- Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation
- Rational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging
- HITS-CLIP Analysis Uncovers a Link between the Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein and Host Pre-mRNA Metabolism
- Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity
- PLOS Pathogens
- Archív čísel
- Aktuálne číslo
- Informácie o časopise
Najčítanejšie v tomto čísle- Control of Murine Cytomegalovirus Infection by γδ T Cells
- ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes
- Rational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging
- Telomeric ORFS in : Does Mediator Tail Wag the Yeast?
Prihlásenie#ADS_BOTTOM_SCRIPTS#Zabudnuté hesloZadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.
- Časopisy