Phylodynamics and Human-Mediated Dispersal of a Zoonotic Virus

English version České info

Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geo-political boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens.

Vyšlo v časopise: Phylodynamics and Human-Mediated Dispersal of a Zoonotic Virus. PLoS Pathog 6(10): e32767. doi:10.1371/journal.ppat.1001166
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1001166

Souhrn

Zdroje

1. KnobelDL

CleavelandS

ColemanPG

FevreEM

MeltzerMI

2005 Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ 83 360 368

2. CleavelandS

MeslinFX

BreimanR

2006 Dogs can play useful role as sentinel hosts for disease. Nature 440 605

3. FevreEM

KaboyoRW

PerssonV

EdelstenM

ColemanPG

2005 The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies. Trop Med Int Health 10 790 798

4. LyS

BuchyP

HengNY

OngS

ChhorN

2009 Rabies situation in cambodia. PLoS Negl Trop Dis 3 e511

5. NelLH

RupprechtCE

2007 Emergence of lyssaviruses in the Old World: the case of Africa. Curr Top Microbiol Immunol 315 161 193

6. BourhyH

ReynesJM

DunhamEJ

DacheuxL

LarrousF

2008 The origin and phylogeography of dog rabies virus. J Gen Virol 89 2673 2681

7. TalbiC

HolmesEC

de BenedictisP

FayeO

NakouneE

2009 Evolutionary history and dynamics of dog rabies virus in western and central Africa. J Gen Virol 90 783 791

8. LemeyP

RambautA

DrummondAJ

SuchardMA

2009 Bayesian phylogeography finds its roots. PLoS Comput Biol 5 e1000520

9. BiekR

HendersonJC

WallerLA

RupprechtCE

RealLA

2007 A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus. Proc Natl Acad Sci U S A 104 7993 7998

10. BourhyH

KissiB

AudryL

SmreczakM

Sadkowska-TodysM

1999 Ecology and evolution of rabies virus in Europe. J Gen Virol 80 ( Pt 10) 2545 2557

11. RealLA

BiekR

2007 Spatial dynamics and genetics of infectious diseases on heterogeneous landscapes. J R Soc Interface 4 935 948

12. RealLA

HendersonJC

BiekR

SnamanJ

JackTL

2005 Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus. Proc Natl Acad Sci U S A 102 12107 12111

13. DrummondAJ

RambautA

2007 BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7 214

14. Ben NéfissaK

MoulinAM

DellagiK

2007 La rage en Tunisie au XIX siècle: recrudescence ou émergence? Gesnerus 64 173 192

15. WangTH

DonaldsonYK

BrettleRP

BellJE

2001 Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system. J Virol 75 11686 11699

16. GrayRR

TatemAJ

LamersS

HouW

LaeyendeckerO

2009 Spatial phylodynamics of HIV-1 epidemic emergence in east Africa. Aids 23 F9 F17

17. McRaeBH

BeierP

2007 Circuit theory predicts gene flow in plant and animal populations. Proc Natl Acad Sci U S A 104 19885 19890

18. BalkDL

DeichmannU

YetmanG

PozziF

HaySI

2006 Determining global population distribution: methods, applications and data. Adv Parasitol 62 119 156

19. MininVN

SuchardM

2008 Counting labeled transitions in continuous-time Markov models of evolution. Journal of Mathematical Biology 56 391 412

20. HampsonK

DushoffJ

BinghamJ

BrucknerG

AliYH

2007 Synchronous cycles of domestic dog rabies in sub-Saharan Africa and the impact of control efforts. Proc Natl Acad Sci U S A 104 7717 7722

21. HampsonK

DushoffJ

CleavelandS

HaydonDT

KaareM

2009 Transmission dynamics and prospects for the elimination of canine rabies. PLoS Biol 7 e53

22. KitalaPM

McDermottJJ

ColemanPG

DyeC

2002 Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya. Epidemiol Infect 129 215 222

23. WandelerAI

MatterHC

KappelerA

BuddeA

1993 The ecology of dogs and canine rabies: a selective review. Rev Sci Tech 12 51 71

24. ZinsstagJ

DurrS

PennyMA

MindekemR

RothF

2009 Transmission dynamics and economics of rabies control in dogs and humans in an African city. Proc Natl Acad Sci U S A 106 14996 15001

25. JenkinsSR

WinklerWG

1987 Descriptive epidemiology from an epizootic of raccoon rabies in the Middle Atlantic States, 1982–1983. Am J Epidemiol 126 429 437

26. WindiyaningsihC

WildeH

MeslinFX

SurosoT

WidarsoHS

2004 The rabies epidemic on Flores Island, Indonesia (1998–2003). J Med Assoc Thai 87 1389 1393

27. BourhyH

DacheuxL

StradyC

MaillesA

2005 Rabies in Europe in 2005. Euro Surveill 10 213 216

28. CleavelandS

KaareM

TiringaP

MlengeyaT

BarratJ

2003 A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries. Vaccine 21 1965 1973

29. ColemanPG

FevreEM

CleavelandS

2004 Estimating the public health impact of rabies. Emerg Infect Dis 10 140 142

30. KayaliU

MindekemR

HuttonG

NdoutamiaAG

ZinsstagJ

2006 Cost-description of a pilot parenteral vaccination campaign against rabies in dogs in N'Djamena, Chad. Trop Med Int Health 11 1058 1065

31. LardonZ

WatierF

BrunetA

BernèdeC

GoudalM

2010 Imported Episodic Rabies Increases Patient Demand for and Physician Delivery of Antirabies Prophylaxis. Plos Neglected Tropical Diseases in press

32. HufnagelL

BrockmannD

GeiselT

2004 Forecast and control of epidemics in a globalized world. Proc Natl Acad Sci U S A 101 15124 15129

33. RussellCA

SmithDL

WallerLA

ChildsJE

RealLA

2004 A priori prediction of disease invasion dynamics in a novel environment. Proc Biol Sci 271 21 25

34. HendersonJC

BiekR

HanlonCA

O'DeeS

RealLA

2008 Rabies virus in raccoons, Ohio, 2004. Emerg Infect Dis 14 650 652

35. TatemAJ

RogersDJ

HaySI

2006 Global transport networks and infectious disease spread. Adv Parasitol 62 293 343

36. KissiB

TordoN

BourhyH

1995 Genetic polymorphism in the rabies virus nucleoprotein gene. Virology 209 526 537

37. DelmasO

HolmesEC

TalbiC

LarrousF

DacheuxL

2008 Genomic diversity and evolution of the lyssaviruses. PLoS ONE 3 e2057

38. EdgarRC

2004 MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32 1792 1797

39. DrummondAJ

HoSY

PhillipsMJ

RambautA

2006 Relaxed phylogenetics and dating with confidence. PLoS Biol 4 e88

40. DrummondAJ

RambautA

ShapiroB

PybusOG

2005 Bayesian coalescent inference of past population dynamics from molecular sequences. Mol Biol Evol 22 1185 1192

41. SuchardMA

RambautA

2009 Many-core algorithms for statistical phylogenetics. Bioinformatics 25 1370 1376

42. O'BrienJD

MininVN

SuchardM

2009 Learning to count: robust estimates for labeled distances between molecular sequences. Molecular Biology and Evolution 26 801 814

43. SuchardM

KitchenC

SinsheimerJ

WeissR

2003 Hierarchical phylogenetic models for analyzing multipartite sequence data. Syst Biol 52 649 664

44. 2000 Road network data. VMAP0 (Vector Map Level 0) Highlands Ranch, Colorado LandInfo Worldwide Mapping

45. RedelingsBD

SuchardMA

2005 Joint Bayesian estimation of alignment and phylogeny. Syst Biol 54 401 418

46. NewtonM

RafteryA

1994 Approximate Bayesian inference with the weighted likelihood bootstrap. Journal of the Royal Statistical Society Series B 56 3 48

Štítky

Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

Článek Social Media and Microbiology Education

Článek Antimicrobial Peptides: Primeval Molecules or Future Drugs?

Článek Retroviral RNA Dimerization and Packaging: The What, How, When, Where, and Why

Článek Distinct Clones of Caused the Black Death

Článek Strain-Specific Differences in the Genetic Control of Two Closely Related Mycobacteria

Článek The Combined Effect of Environmental and Host Factors on the Emergence of Viral RNA Recombinants

Článek MHC Class I Bound to an Immunodominant Epitope Demonstrates Unconventional Presentation to T Cell Receptors

Článek Stimulates Immune Gene Expression and Inhibits Development in

Článek Crystal Structure of DotD: Insights into the Relationship between Type IVB and Type II/III Secretion Systems

Článek Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands

Článek Strategies to Avoid Killing by Human Neutrophils

Článek Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

Článek Autoimmunity in Arabidopsis Is Mediated by Epigenetic Regulation of an Immune Receptor

Článek Functional Interchangeability of Late Domains, Late Domain Cofactors and Ubiquitin in Viral Budding

Článek Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids

Článek Nucleocapsid Promotes Localization of HIV-1 Gag to Uropods That Participate in Virological Synapses between T Cells

Článek Host Genetics and HIV-1: The Final Phase?

Článek Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype?

Článek High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing

Článek Viral Replication Rate Regulates Clinical Outcome and CD8 T Cell Responses during Highly Pathogenic H5N1 Influenza Virus Infection in Mice

Článek Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Článek Parvovirus Minute Virus of Mice Induces a DNA Damage Response That Facilitates Viral Replication

Článek -Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite Metalloprotease GP63

Článek Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation and Antigen Presentation

Článek Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

Článek The Spread of Tomato Yellow Leaf Curl Virus from the Middle East to the World

Článek Concerted Action of Two Formins in Gliding Motility and Host Cell Invasion by

Článek Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

Článek Release of Intracellular Calcium Stores Facilitates Coxsackievirus Entry into Polarized Endothelial Cells

Článek Gene Annotation and Drug Target Discovery in with a Tagged Transposon Mutant Collection

Článek Nuclear Export and Import of Human Hepatitis B Virus Capsid Protein and Particles

Článek Retention and Loss of RNA Interference Pathways in Trypanosomatid Protozoans

Článek Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite

Článek Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

Článek Direct Visualization of Peptide/MHC Complexes at the Surface and in the Intracellular Compartments of Cells Infected by

Článek Phenolglycolipid-1 Expressed by Engineered BCG Modulates Early Interaction with Human Phagocytes

Článek In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions

Článek Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry

Článok vyšiel v časopise

PLOS Pathogens

2010 Číslo 10

Najčítanejšie tento týždeň

Najčítanejšie v tomto čísle

Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Získaná hemofilie - Povědomí o nemoci a její diagnostika

nový kurz

Eozinofilní granulomatóza s polyangiitidou

Autori: doc. MUDr. Martina Doubková, Ph.D.

Všetky kurzy