Weighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?


In this Perspective, Alberto Ascherio and Kassandra Munger discuss the implications of Richards and colleagues' study exploring the role of early-life obesity in risk of multiple sclerosis.


Vyšlo v časopise: Weighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?. PLoS Med 13(6): e32767. doi:10.1371/journal.pmed.1002054
Kategorie: Perspective
prolekare.web.journal.doi_sk: 10.1371/journal.pmed.1002054

Souhrn

In this Perspective, Alberto Ascherio and Kassandra Munger discuss the implications of Richards and colleagues' study exploring the role of early-life obesity in risk of multiple sclerosis.


Zdroje

1. Munger KL, Chitnis T, Ascherio A. (2009) Body size and risk of MS in two cohorts of US women. Neurology 73: 1543–1550. doi: 10.1212/WNL.0b013e3181c0d6e0 19901245

2. Munger KL, Bentzen J, Laursen B, Stenager E, Koch-Henriksen N, et al. (2013) Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler 19: 1323–1329. doi: 10.1177/1352458513483889 23549432

3. Hedstrom AK, Olsson T, Alfredsson L. (2012) High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 18: 1334–1336. doi: 10.1177/1352458512436596 22328681

4. Wesnes K, Riise T, Casetta I, Drulovic J, Granieri E, et al. (2015) Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study. Mult Scler 21: 388–395. doi: 10.1177/1352458514546785 25182290

5. Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, et al. (2014) Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract 8: e435–447. doi: 10.1016/j.orcp.2014.01.002 25263833

6. Mokry LE, Ross S, Timpson NJ, Sawcer S, Davey Smith G, Richards BJ. Obesity and multiple sclerosis: a medelian randomization study. PLoS Med 2016.

7. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518: 197–206. doi: 10.1038/nature14177 25673413

8. Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, et al. (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45: 1353–1360. doi: 10.1038/ng.2770 24076602

9. International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium, Sawcer S, Hellenthal G, Pirinen M, et al. (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214–219. doi: 10.1038/nature10251 21833088

10. Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, et al. (2016) Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr.

11. Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, et al. (2015) The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 11: e1005378. doi: 10.1371/journal.pgen.1005378 26426971

12. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, et al. (2010) Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 19: 545–552. doi: 10.1093/hmg/ddp504 19880856

13. Elks CE, Loos RJ, Hardy R, Wills AK, Wong A, et al. (2012) Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr 95: 1150–1156. doi: 10.3945/ajcn.111.027870 22456663

14. Glymour MM, Tchetgen Tchetgen EJ, Robins JM. (2012) Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol 175: 332–339. doi: 10.1093/aje/kwr323 22247045

15. Hill AB. (1965) The Environment and Disease: Association or Causation? Proc R Soc Med 58: 295–300. 14283879

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2016 Číslo 6
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