Cancer Genomics: Large-Scale Projects Translate into Therapeutic Advances

English version České info

Elaine Mardis and Marc Ladanyi discuss how large-scale genomics has driven advances in cancer translational medicine, with a focus on publications in this month's Special Issue.

Vyšlo v časopise: Cancer Genomics: Large-Scale Projects Translate into Therapeutic Advances. PLoS Med 13(12): e32767. doi:10.1371/journal.pmed.1002209
Kategorie: Editorial
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002209

Souhrn

Elaine Mardis and Marc Ladanyi discuss how large-scale genomics has driven advances in cancer translational medicine, with a focus on publications in this month's Special Issue.

Zdroje

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2. Loi S, Savas P, Teo ZL, Lefevre C, Flensburg C, et al. The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE". PLoS Med. 2016;13(12):e1002204. doi: 10.1371/journal.pmed.1002204

3. Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461(7265):809–13. doi: 10.1038/nature08489 19812674

4. Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 2010 Apr 15;464(7291):999–1005. doi: 10.1038/nature08989 20393555

5. Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012 Mar 8;366(10):883–92. doi: 10.1056/NEJMoa1113205 22397650

6. Brenton J, Parkinson CA, Gale D, Piskorz A, Biggs H, et al. Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Analysis. PLoS Med. 2016;13(12):e1002198. doi: 10.1371/journal.pmed.1002198

7. Dutta A, Reon BJ, Anaya J, Zhang Y, Mandell J, et al. Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis. PLoS Med. 2016;13(12):e1002192. doi: 10.1371/journal.pmed.1002192 27923049

8. Li Y, Buijs-Gladdines JG, Canté-Barrett K, Stubbs AP, Vroegindeweij EM, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T Cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13(12):e1002200. doi: 10.1371/journal.pmed.1002200