The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

1. FuchsE 2009 The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 137 811 819

2. CotsarelisG 2006 Epithelial stem cells: a folliculocentric view. J Invest Dermatol 126 1459 1468

3. BlanpainCFuchsE 2009 Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 10 207 217

4. ZhangYVCheongJCiapurinNMcDermittDJTumbarT 2009 Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell 5 267 278

5. GrecoVChenTRendlMSchoberMPasolliHA 2009 A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4 155 169

6. MurphyMJWilsonATrumppA 2005 More than just proliferation: Myc function in stem cells. Trends Cell Biol 15 128 137

7. WattFMFryeMBenitahSA 2008 MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer 8 234 242

8. WilsonALaurentiETrumppA 2009 Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev 19 461 468

9. ArnoldIWattFM 2001 c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 11 558 568

10. WaikelRLKawachiYWaikelPAWangXJRoopDR 2001 Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 28 165 168

11. FryeMGardnerCLiERArnoldIWattFM 2003 Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 130 2793 2808

12. FryeMWattFM 2006 The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol 16 971 981

13. BrzezichaBSchmidtMMakalowskaIJarmolowskiAPienkowskaJ 2006 Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). Nucleic Acids Res 34 6034 6043

14. HussainSBenaventeSBNascimentoEDragoniIKurowskiA 2009 The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability. J Cell Biol 186 27 40

15. SuzukiMMBirdA 2008 DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9 465 476

16. MotorinYLykoFHelmM 2010 5-methylcytosine in RNA: detection, enzymatic formation and biological functions. Nucleic Acids Res 38 1415 1430

17. SchaeferMPollexTHannaKTuortoFMeusburgerM 2010 RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev 24 1590 1595

18. GollMGKirpekarFMaggertKAYoderJAHsiehCL 2006 Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311 395 398

19. MotorinYGrosjeanH 1999 Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. Rna 5 1105 1118

20. KingMYRedmanKL 2002 RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. Biochemistry 41 11218 11225

21. SchaeferMPollexTHannaKLykoF 2009 RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res 37 e12

22. FuchsE 2007 Scratching the surface of skin development. Nature 445 834 842

23. HusseinSMDuffEKSirardC 2003 Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem 278 48805 48814

24. BlanpainCLowryWEGeogheganAPolakLFuchsE 2004 Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118 635 648

25. BraunKMNiemannCJensenUBSundbergJPSilva-VargasV 2003 Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 130 5241 5255

26. SchweizerJMarksF 1977 Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 37 4195 4201

27. SchweizerJMarksF 1977 A developmental study of the distribution and frequency of Langerhans cells in relation to formation of patterning in mouse tail epidermis. J Invest Dermatol 69 198 204

28. OshimaHRochatAKedziaCKobayashiKBarrandonY 2001 Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104 233 245

29. JonesPHHarperSWattFM 1995 Stem cell patterning and fate in human epidermis. Cell 80 83 93

30. MerrillBJGatUDasGuptaRFuchsE 2001 Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev 15 1688 1705

31. WattFMJensenKB 2009 Epidermal stem cell diversity and quiescence. EMBO Mol Med 1 260 267

32. LiLCleversH 2010 Coexistence of quiescent and active adult stem cells in mammals. Science 327 542 545

33. HsuYCPasolliHAFuchsE 2011 Dynamics between stem cells, niche, and progeny in the hair follicle. Cell 144 92 105

34. BakerCMVerstuyfAJensenKBWattFM 2010 Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol 343 40 50

35. GatUDasGuptaRDegensteinLFuchsE 1998 De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95 605 614

36. Lo CelsoCProwseDMWattFM 2004 Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development 131 1787 1799

37. LowryWEBlanpainCNowakJAGuaschGLewisL 2005 Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 19 1596 1611

38. Van MaterDKolligsFTDlugoszAAFearonER 2003 Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev 17 1219 1224

39. AndlTReddySTGaddaparaTMillarSE 2002 WNT signals are required for the initiation of hair follicle development. Dev Cell 2 643 653

40. HuelskenJVogelRErdmannBCotsarelisGBirchmeierW 2001 beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105 533 545

41. NiemannCWattFM 2002 Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol 12 185 192

42. MotorinYHelmM 2010 tRNA stabilization by modified nucleotides. Biochemistry 49 4934 4944

43. ChernyakovIWhippleJMKotelawalaLGrayhackEJPhizickyEM 2008 Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5′-3′ exonucleases Rat1 and Xrn1. Genes Dev 22 1369 1380

44. RaiKChidesterSZavalaCVManosEJJamesSR 2007 Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev 21 261 266

45. PedersonT 2010 Regulatory RNAs derived from transfer RNA? RNA 16 1865 1869

46. BurroughsAMAndoYHoonMLTomaruYSuzukiH 2011 Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin. RNA Biol 8

47. ColeCSobalaALuCThatcherSRBowmanA 2009 Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. Rna 15 2147 2160

48. PhizickyEMHopperAK 2010 tRNA biology charges to the front. Genes Dev 24 1832 1860

49. SampathPPritchardDKPabonLReineckeHSchwartzSM 2008 A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Cell Stem Cell 2 448 460

50. RodriguezCIBuchholzFGallowayJSequerraRKasperJ 2000 High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25 139 140

51. Muller-RoverSHandjiskiBvan der VeenCEichmullerSFoitzikK 2001 A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 117 3 15

52. BruhnLMunnerlynAGrosschedlR 1997 ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev 11 640 653