#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in


Parkinson's disease (PD)-mimicking drugs and pesticides, and more recently PD-associated gene mutations, have been studied in cell cultures and mammalian models to decipher the molecular basis of PD. Thus far, a dozen of genes have been identified that are responsible for inherited PD. However they only account for about 8% of PD cases, most of the cases likely involving environmental contributions. Environmental manganese (Mn) exposure represents an established risk factor for PD occurrence, and both PD and Mn-intoxicated patients display a characteristic extrapyramidal syndrome primarily involving dopaminergic (DAergic) neurodegeneration with shared common molecular mechanisms. To better understand the specificity of DAergic neurodegeneration, we studied Mn toxicity in vivo in Caenorhabditis elegans. Combining genetics and biochemical assays, we established that extracellular, and not intracellular, dopamine (DA) is responsible for Mn-induced DAergic neurodegeneration and that this process (1) requires functional DA-reuptake transporter (DAT-1) and (2) is associated with oxidative stress and lifespan reduction. Overexpression of the anti-oxidant transcription factor, SKN-1, affords protection against Mn toxicity, while the DA-dependency of Mn toxicity requires the NADPH dual-oxidase BLI-3. These results suggest that in vivo BLI-3 activity promotes the conversion of extracellular DA into toxic reactive species, which, in turn, can be taken up by DAT-1 in DAergic neurons, thus leading to oxidative stress and cell degeneration.


Vyšlo v časopise: Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in. PLoS Genet 6(8): e32767. doi:10.1371/journal.pgen.1001084
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1001084

Souhrn

Parkinson's disease (PD)-mimicking drugs and pesticides, and more recently PD-associated gene mutations, have been studied in cell cultures and mammalian models to decipher the molecular basis of PD. Thus far, a dozen of genes have been identified that are responsible for inherited PD. However they only account for about 8% of PD cases, most of the cases likely involving environmental contributions. Environmental manganese (Mn) exposure represents an established risk factor for PD occurrence, and both PD and Mn-intoxicated patients display a characteristic extrapyramidal syndrome primarily involving dopaminergic (DAergic) neurodegeneration with shared common molecular mechanisms. To better understand the specificity of DAergic neurodegeneration, we studied Mn toxicity in vivo in Caenorhabditis elegans. Combining genetics and biochemical assays, we established that extracellular, and not intracellular, dopamine (DA) is responsible for Mn-induced DAergic neurodegeneration and that this process (1) requires functional DA-reuptake transporter (DAT-1) and (2) is associated with oxidative stress and lifespan reduction. Overexpression of the anti-oxidant transcription factor, SKN-1, affords protection against Mn toxicity, while the DA-dependency of Mn toxicity requires the NADPH dual-oxidase BLI-3. These results suggest that in vivo BLI-3 activity promotes the conversion of extracellular DA into toxic reactive species, which, in turn, can be taken up by DAT-1 in DAergic neurons, thus leading to oxidative stress and cell degeneration.


Zdroje

1. PostJE

1999 Manganese oxide minerals: crystal structures and economic and environmental significance. Proc Natl Acad Sci U S A 96 3447 3454

2. ProhaskaJR

1987 Functions of trace elements in brain metabolism. Physiol Rev 67 858 901

3. TakedaA

SotogakuN

OkuN

2003 Influence of manganese on the release of neurotransmitters in rat striatum. Brain Res 965 279 282

4. BalyDL

KeenCL

HurleyLS

1985 Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in developing rats: effect of manganese deficiency. J Nutr 115 872 879

5. BrockCJ

WalkerJE

1980 Superoxide dismutase from Bacillus stearothermophilus. Complete amino acid sequence of a manganese enzyme. Biochemistry 19 2873 2882

6. TakedaY

AvilaH

1986 Structure and gene expression of the E. coli Mn-superoxide dismutase gene. Nucleic Acids Res 14 4577 4589

7. SaricM

1986 Manganese.

Lars FribergGFN

VelmirBVouk

Handbook on The Toxicology of Metals Amsterdam Elsevier Science Publishers B.V 354 386

8. WedlerFC

DenmanRB

1984 Glutamine synthetase: the major Mn(II) enzyme in mammalian brain. Curr Top Cell Regul 24 153 169

9. AuC

BenedettoA

AschnerM

2008 Manganese transport in eukaryotes: the role of DMT1. Neurotoxicology 29 569 576

10. AschnerM

AschnerJL

1991 Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci Biobehav Rev 15 333 340

11. ThompsonK

MolinaRM

DonagheyT

SchwobJE

BrainJD

2007 Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. FASEB J 21 223 230

12. DormanDC

McManusBE

ParkinsonCU

ManuelCA

McElveenAM

2004 Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure. Inhal Toxicol 16 481 488

13. WassermanGA

LiuX

ParvezF

AhsanH

LevyD

2006 Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 114 124 129

14. MyersJE

teWaterNaudeJ

FourieM

ZogoeHB

NaikI

2003 Nervous system effects of occupational manganese exposure on South African manganese mineworkers. Neurotoxicology 24 649 656

15. PalPK

SamiiA

CalneDB

1999 Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology 20 227 238

16. FerrazHB

BertolucciPH

PereiraJS

LimaJG

AndradeLA

1988 Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 38 550 553

17. AbbottPJ

1987 Methylcyclopentadienyl manganese tricarbonyl (MMT) in petrol: the toxicological issues. Sci Total Environ 67 247 255

18. CooperWC

1984 The health implications of increased manganese in the environment resulting from the combustion of fuel additives: a review of the literature. J Toxicol Environ Health 14 23 46

19. FrumkinH

SolomonG

1997 Manganese in the U.S. gasoline supply. Am J Ind Med 31 107 115

20. SierraP

LorangerS

KennedyG

ZayedJ

1995 Occupational and environmental exposure of automobile mechanics and nonautomotive workers to airborne manganese arising from the combustion of methylcyclopentadienyl manganese tricarbonyl (MMT). Am Ind Hyg Assoc J 56 713 716

21. McKinneyAM

FiliceRW

TeksamM

CaseyS

TruwitC

2004 Diffusion abnormalities of the globi pallidi in manganese neurotoxicity. Neuroradiology 46 291 295

22. NewlandMC

CecklerTL

KordowerJH

WeissB

1989 Visualizing manganese in the primate basal ganglia with magnetic resonance imaging. Exp Neurol 106 251 258

23. CalneDB

ChuNS

HuangCC

LuCS

OlanowW

1994 Manganism and idiopathic parkinsonism: similarities and differences. Neurology 44 1583 1586

24. CersosimoMG

KollerWC

2006 The diagnosis of manganese-induced parkinsonism. Neurotoxicology 27 340 346

25. OlanowCW

2004 Manganese-induced parkinsonism and Parkinson's disease. Ann N Y Acad Sci 1012 209 223

26. GorellJM

JohnsonCC

RybickiBA

PetersonEL

KortshaGX

1999 Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease. Neurotoxicology 20 239 247

27. KimY

KimJW

ItoK

LimHS

CheongHK

1999 Idiopathic parkinsonism with superimposed manganese exposure: utility of positron emission tomography. Neurotoxicology 20 249 252

28. RacetteBA

McGee-MinnichL

MoerleinSM

MinkJW

VideenTO

2001 Welding-related parkinsonism: clinical features, treatment, and pathophysiology. Neurology 56 8 13

29. HudnellHK

1999 Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies. Neurotoxicology 20 379 397

30. NormandinL

PanissetM

ZayedJ

2002 Manganese neurotoxicity: behavioral, pathological, and biochemical effects following various routes of exposure. Rev Environ Health 17 189 217

31. RacetteBA

TabbalSD

JenningsD

GoodL

PerlmutterJS

2005 Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders. Neurology 64 230 235

32. BenedettoA

AuC

AschnerM

2009 Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease. Chem Rev 109 4862 4884

33. ChiuehCC

WuRM

MohanakumarKP

SternbergerLM

KrishnaG

1994 In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Ann N Y Acad Sci 738 25 36

34. De IuliisA

GrigolettoJ

RecchiaA

GiustiP

ArslanP

2005 A proteomic approach in the study of an animal model of Parkinson's disease. Clin Chim Acta 357 202 209

35. JennerP

1998 Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 13 Suppl 1 24 34

36. VedR

SahaS

WestlundB

PerierC

BurnamL

2005 Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem 280 42655 42668

37. ShererTB

BetarbetR

TestaCM

SeoBB

RichardsonJR

2003 Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci 23 10756 10764

38. KienzlE

PuchingerL

JellingerK

LinertW

StachelbergerH

1995 The role of transition metals in the pathogenesis of Parkinson's disease. J Neurol Sci 134 Suppl 69 78

39. MontgomeryEBJr

1995 Heavy metals and the etiology of Parkinson's disease and other movement disorders. Toxicology 97 3 9

40. OestreicherE

SengstockGJ

RiedererP

OlanowCW

DunnAJ

1994 Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain Res 660 8 18

41. BrouilletEP

ShinobuL

McGarveyU

HochbergF

BealMF

1993 Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol 120 89 94

42. LoschmannPA

LangeKW

WachtelH

TurskiL

1994 MPTP-induced degeneration: interference with glutamatergic toxicity. J Neural Transm Suppl 43 133 143

43. ChunHS

GibsonGE

DeGiorgioLA

ZhangH

KiddVJ

2001 Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 76 1010 1021

44. SuzukiY

MouriT

SuzukiY

NishiyamaK

FujiiN

1975 Study of subacute toxicity of manganese dioxide in monkeys. Tokushima J Exp Med 22 5 10

45. HaMaiD

BondySC

2004 Oxidative basis of manganese neurotoxicity. Ann N Y Acad Sci 1012 129 141

46. MigheliR

GodaniC

SciolaL

DeloguMR

SerraPA

1999 Enhancing effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress. J Neurochem 73 1155 1163

47. ParentiM

RusconiL

CappabiancaV

ParatiEA

GroppettiA

1988 Role of dopamine in manganese neurotoxicity. Brain Res 473 236 240

48. Tomas-CamardielM

HerreraAJ

VeneroJL

Cruz Sanchez-HidalgoM

CanoJ

2002 Differential regulation of glutamic acid decarboxylase mRNA and tyrosine hydroxylase mRNA expression in the aged manganese-treated rats. Brain Res Mol Brain Res 103 116 129

49. HsuLJ

SagaraY

ArroyoA

RockensteinE

SiskA

2000 alpha-synuclein promotes mitochondrial deficit and oxidative stress. Am J Pathol 157 401 410

50. ShererTB

BetarbetR

StoutAK

LundS

BaptistaM

2002 An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22 7006 7015

51. TanakaY

EngelenderS

IgarashiS

RaoRK

WannerT

2001 Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 10 919 926

52. WitholtR

GwiazdaRH

SmithDR

2000 The neurobehavioral effects of subchronic manganese exposure in the presence and absence of pre-parkinsonism. Neurotoxicol Teratol 22 851 861

53. KuwaharaT

KoyamaA

Gengyo-AndoK

MasudaM

KowaH

2006 Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. J Biol Chem 281 334 340

54. BraungartE

GerlachM

RiedererP

BaumeisterR

HoenerMC

2004 Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings. Neurodegener Dis 1 175 183

55. LaksoM

VartiainenS

MoilanenAM

SirvioJ

ThomasJH

2003 Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J Neurochem 86 165 172

56. NassR

HallDH

MillerDM3rd

BlakelyRD

2002 Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc Natl Acad Sci U S A 99 3264 3269

57. LockeCJ

FoxSA

CaldwellGA

CaldwellKA

2008 Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neurosci Lett 439 129 133

58. WangYM

PuP

LeWD

2007 ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in alpha-synuclein transgenic C. elegans. Neurosci Bull 23 329 335

59. GitlerAD

ChesiA

GeddieML

StrathearnKE

HamamichiS

2009 Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41 308 315

60. van HamTJ

ThijssenKL

BreitlingR

HofstraRM

PlasterkRH

2008 C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet 4 e1000027 doi:10.1371/journal.pgen.1000027

61. KuwaharaT

KoyamaA

KoyamaS

YoshinaS

RenCH

2008 A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum Mol Genet 17 2997 3009

62. IchibangaseT

SaimaruH

TakamuraN

KuwaharaT

KoyamaA

2008 Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages. Biomed Chromatogr 22 232 234

63. CaoS

GelwixCC

CaldwellKA

CaldwellGA

2005 Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J Neurosci 25 3801 3812

64. HamamichiS

RivasRN

KnightAL

CaoS

CaldwellKA

2008 Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci U S A 105 728 733

65. SettivariR

LevoraJ

NassR

2009 The divalent metal transporter homologues SMF-1/2 mediates dopamine neuron sensitivity in caenorhabditis elegans models of manganism and Parkinson's disease. J Biol Chem

66. AuC

BenedettoA

AndersonJ

LabrousseA

EriksonK

2009 SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS ONE 4 e7792 doi:10.1371/journal.pone.0007792

67. CassWA

ZahniserNR

FlachKA

GerhardtGA

1993 Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors. J Neurochem 61 2269 2278

68. KiltyJE

LorangD

AmaraSG

1991 Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 254 578 579

69. ShimadaS

KitayamaS

LinCL

PatelA

NanthakumarE

1991 Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254 576 578

70. HuotariM

SanthaM

LucasLR

KarayiorgouM

GogosJA

2002 Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther 303 1309 1316

71. McDonaldPW

HardieSL

JessenTN

CarvelliL

MatthiesDS

2007 Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. J Neurosci 27 14216 14227

72. NassR

HahnMK

JessenT

McDonaldPW

CarvelliL

2005 A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. J Neurochem 94 774 785

73. ArchibaldFS

TyreeC

1987 Manganese poisoning and the attack of trivalent manganese upon catecholamines. Arch Biochem Biophys 256 638 650

74. GrahamDG

1984 Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease. Neurotoxicology 5 83 95

75. SistrunkSC

RossMK

FilipovNM

2007 Direct effects of manganese compounds on dopamine and its metabolite Dopac: an in vitro study. Environ Toxicol Pharmacol 23 286 296

76. ParisI

Dagnino-SubiabreA

MarcelainK

BennettLB

CaviedesP

2001 Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J Neurochem 77 519 529

77. PongK

DoctrowSR

BaudryM

2000 Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res 881 182 189

78. ChaseDL

PepperJS

KoelleMR

2004 Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci 7 1096 1103

79. LinYT

HoangH

HsiehSI

RangelN

FosterAL

2006 Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant. Free Radic Biol Med 40 1185 1193

80. SingerTP

RamsayRR

AckrellBA

1995 Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies. Biochim Biophys Acta 1271 211 219

81. BockelmannR

WolfG

RansmayrG

RiedererP

1994 NADPH-diaphorase/nitric oxide synthase containing neurons in normal and Parkinson's disease putamen. J Neural Transm Park Dis Dement Sect 7 115 121

82. JennerP

1991 Oxidative stress as a cause of Parkinson's disease. Acta Neurol Scand Suppl 136 6 15

83. JennerP

2003 Oxidative stress in Parkinson's disease. Ann Neurol 53 Suppl 3 S26 36; discussion S36–28

84. CassarinoDS

FallCP

SwerdlowRH

SmithTS

HalvorsenEM

1997 Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease. Biochim Biophys Acta 1362 77 86

85. YooMS

ChunHS

SonJJ

DeGiorgioLA

KimDJ

2003 Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's disease. Brain Res Mol Brain Res 110 76 84

86. WuDC

TeismannP

TieuK

VilaM

Jackson-LewisV

2003 NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A 100 6145 6150

87. LothariusJ

DuganLL

O'MalleyKL

1999 Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 19 1284 1293

88. SchapiraAH

1995 Oxidative stress in Parkinson's disease. Neuropathol Appl Neurobiol 21 3 9

89. LinertW

HerlingerE

JamesonRF

KienzlE

JellingerK

1996 Dopamine, 6-hydroxydopamine, iron, and dioxygen–their mutual interactions and possible implication in the development of Parkinson's disease. Biochim Biophys Acta 1316 160 168

90. MilneGL

YinH

BrooksJD

SanchezS

Jackson RobertsL2nd

2007 Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Methods Enzymol 433 113 126

91. FamSS

MorrowJD

2003 The isoprostanes: unique products of arachidonic acid oxidation-a review. Curr Med Chem 10 1723 1740

92. TaberDF

MorrowJD

RobertsLJ2nd

1997 A nomenclature system for the isoprostanes. Prostaglandins 53 63 67

93. OliveiraRP

Porter AbateJ

DilksK

LandisJ

AshrafJ

2009 Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8 524 541

94. AnJH

BlackwellTK

2003 SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17 1882 1893

95. BowermanB

EatonBA

PriessJR

1992 skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68 1061 1075

96. KellA

VenturaN

KahnN

JohnsonTE

2007 Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med 43 1560 1566

97. TulletJM

HertweckM

AnJH

BakerJ

HwangJY

2008 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025 1038

98. AnJH

VranasK

LuckeM

InoueH

HisamotoN

2005 Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 102 16275 16280

99. ParkSK

TedescoPM

JohnsonTE

2009 Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8 258 269

100. DennisKE

AschnerJL

MilatovicD

SchmidtJW

AschnerM

2009 NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol 297 L596 607

101. Bonneh-BarkayD

ReaneySH

LangstonWJ

Di MonteDA

2005 Redox cycling of the herbicide paraquat in microglial cultures. Brain Res Mol Brain Res 134 52 56

102. GaoHM

LiuB

HongJS

2003 Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 23 6181 6187

103. AnantharamV

KaulS

SongC

KanthasamyA

KanthasamyAG

2007 Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology 28 988 997

104. TheinMC

WinterAD

StepekG

McCormackG

StapletonG

2009 Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. J Biol Chem 284 17549 17563

105. JainC

YunM

PolitzSM

RaoRP

2009 A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis. Eukaryot Cell 8 1218 1227

106. ChavezV

Mohri-ShiomiA

GarsinDA

2009 Ce-Duox1/BLI-3 generates reactive oxygen species as a protective innate immune mechanism in Caenorhabditis elegans. Infect Immun 77 4983 4989

107. SalazarJ

MenaN

HunotS

PrigentA

Alvarez-FischerD

2008 Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A 105 18578 18583

108. SongN

JiangH

WangJ

XieJX

2007 Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. J Neurosci Res 85 3118 3126

109. ZhangS

WangJ

SongN

XieJ

JiangH

2008 Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells. Neurobiol Aging

110. BarzilaiA

MelamedE

2003 Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease. Trends Mol Med 9 126 132

111. BetarbetR

ShererTB

GreenamyreJT

2002 Animal models of Parkinson's disease. Bioessays 24 308 318

112. Afonso-OramasD

Cruz-MurosI

de la RosaDA

AbreuP

GiraldezT

2009 Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease. Neurobiol Dis 36 494 508

113. McKinleyET

BaranowskiTC

BlavoDO

CatoC

DoanTN

2005 Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons. Brain Res Mol Brain Res 141 128 137

114. StorchA

LudolphAC

SchwarzJ

2004 Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration. J Neural Transm 111 1267 1286

115. PrabhakaranK

GhoshD

ChapmanGD

GunasekarPG

2008 Molecular mechanism of manganese exposure-induced dopaminergic toxicity. Brain Res Bull 76 361 367

116. ReaneySH

SmithDR

2005 Manganese oxidation state mediates toxicity in PC12 cells. Toxicol Appl Pharmacol 205 271 281

117. MilatovicD

Zaja-MilatovicS

GuptaRC

YuY

AschnerM

2009 Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol 240 219 225

118. MilatovicD

YinZ

GuptaRC

SidorykM

AlbrechtJ

2007 Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci 98 198 205

119. OlneyJW

ZorumskiCF

StewartGR

PriceMT

WangGJ

1990 Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases. Exp Neurol 108 269 272

120. Van Den BoschL

Van DammeP

BogaertE

RobberechtW

2006 The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta 1762 1068 1082

121. BerrettaN

FreestonePS

GuatteoE

de CastroD

GeracitanoR

2005 Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro. Neurotoxicology 26 869 881

122. WersingerC

ProuD

VernierP

SidhuA

2003 Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J 17 2151 2153

123. KernCH

StanwoodGD

SmithDR

Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels. Synapse 64 363 378

124. McDougallSA

ReichelCM

FarleyCM

FlesherMM

Der-GhazarianT

2008 Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes. Neuroscience 154 848 860

125. BishopNA

GuarenteL

2007 Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447 545 549

126. BerkowitzLA

HamamichiS

KnightAL

HarringtonAJ

CaldwellGA

2008 Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes. J Vis Exp

127. MarvanovaM

NicholsCD

2007 Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA. J Mol Neurosci 31 127 137

128. SpringerW

HoppeT

SchmidtE

BaumeisterR

2005 A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum Mol Genet 14 3407 3423

129. SamannJ

HegermannJ

von GromoffE

EimerS

BaumeisterR

2009 Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem 284 16482 16491

130. ChenPC

VargasMR

PaniAK

SmeyneRJ

JohnsonDA

2009 Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A 106 2933 2938

131. CuadradoA

Moreno-MurcianoP

Pedraza-ChaverriJ

2009 The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opin Ther Targets 13 319 329

132. van MuiswinkelFL

KuiperijHB

2005 The Nrf2-ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders. Curr Drug Targets CNS Neurol Disord 4 267 281

133. ParkRM

BowlerRM

EggerthDE

DiamondE

SpencerKJ

2006 Issues in neurological risk assessment for occupational exposures: the Bay Bridge welders. Neurotoxicology 27 373 384

134. McMillanG

2005 Is electric arc welding linked to manganism or Parkinson's disease? Toxicol Rev 24 237 257

135. SadekAH

RauchR

SchulzPE

2003 Parkinsonism due to manganism in a welder. Int J Toxicol 22 393 401

136. WennbergA

IregrenA

StruweG

CizinskyG

HagmanM

1991 Manganese exposure in steel smelters a health hazard to the nervous system. Scand J Work Environ Health 17 255 262

137. AndersonJG

CooneyPT

EriksonKM

2007 Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environ Toxicol Pharmacol 23 179 184

138. GraumannR

ParisI

Martinez-AlvaradoP

RumanqueP

Perez-PasteneC

2002 Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase. Pol J Pharmacol 54 573 579

139. ShenXM

DryhurstG

1998 Iron- and manganese-catalyzed autoxidation of dopamine in the presence of L-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity. Chem Res Toxicol 11 824 837

140. ParisI

Martinez-AlvaradoP

CardenasS

Perez-PasteneC

GraumannR

2005 Dopamine-dependent iron toxicity in cells derived from rat hypothalamus. Chem Res Toxicol 18 415 419

141. ZoccaratoF

ToscanoP

AlexandreA

2005 Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease. J Biol Chem 280 15587 15594

142. BaezS

LindersonY

Segura-AguilarJ

1995 Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase. Biochem Mol Med 54 12 18

143. ParisI

CardenasS

LozanoJ

Perez-PasteneC

GraumannR

2007 Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease. Neurotox Res 12 125 134

144. ZafarKS

SiegelD

RossD

2006 A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol Pharmacol 70 1079 1086

145. Diaz-VelizG

MoraS

DossiMT

GomezP

ArriagadaC

2002 Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra. Pharmacol Biochem Behav 73 843 850

146. De IuliisA

BurlinaAP

BoschettoR

ZambenedettiP

ArslanP

2002 Increased dopamine peroxidation in postmortem Parkinsonian brain. Biochim Biophys Acta 1573 63 67

147. GalzignaL

SchiappelliMP

RigoA

ScarpaM

1999 A rat brain fraction and different purified peroxidases catalyzing the formation of dopaminochrome from dopamine. Biochim Biophys Acta 1427 329 336

148. RothJA

HorbinskiC

HigginsD

LeinP

GarrickMD

2002 Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology 23 147 157

149. TjalveH

MejareC

Borg-NeczakK

1995 Uptake and transport of manganese in primary and secondary olfactory neurones in pike. Pharmacol Toxicol 77 23 31

150. SlootWN

GramsbergenJB

1994 Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res 657 124 132

151. TholeyG

Megias-MegiasL

WedlerFC

LedigM

1990 Modulation of Mn2+ accumulation in cultured rat neuronal and astroglial cells. Neurochem Res 15 751 754

152. OchsSD

WestfallTC

MacarthurH

2005 The separation and quantification of aminochromes using high-pressure liquid chromatography with electrochemical detection. J Neurosci Methods 142 201 208

153. Del MaestroR

McDonaldW

1987 Distribution of superoxide dismutase, glutathione peroxidase and catalase in developing rat brain. Mech Ageing Dev 41 29 38

154. DumontM

WilleE

StackC

CalingasanNY

BealMF

2009 Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J 23 2459 2466

155. PengJ

StevensonFF

DoctrowSR

AndersenJK

2005 Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem 280 29194 29198

156. JainM

NehraS

TrivediPC

SinghRV

2002 Nematicidal, Fungicidal and Bactericidal Activities of Manganese (II) Complexes with Heterocyclic Sulphonamide Imines. Met Based Drugs 9 53 60

157. SawinER

RanganathanR

HorvitzHR

2000 C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26 619 631

158. HillsT

BrockiePJ

MaricqAV

2004 Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J Neurosci 24 1217 1225

159. O'RourkeEJ

SoukasAA

CarrCE

RuvkunG

2009 C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab 10 430 435

160. Canonne-HergauxF

GruenheidS

GovoniG

GrosP

1999 The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians 111 283 289

161. SearleS

BrightNA

RoachTI

AtkinsonPG

BartonCH

1998 Localisation of Nramp1 in macrophages: modulation with activation and infection. J Cell Sci 111 ( Pt 19) 2855 2866

162. MackenzieB

HedigerMA

2004 SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch 447 571 579

163. ForbesJR

GrosP

2001 Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol 9 397 403

164. BandyopadhyayJ

SongHO

ParkBJ

SingaraveluG

SunJL

2009 Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans. Biochem Biophys Res Commun 390 136 141

165. JangH

BoltzDA

WebsterRG

SmeyneRJ

2009 Viral parkinsonism. Biochim Biophys Acta 1792 714 721

166. Diaz-CorralesFJ

ColasanteC

ContrerasQ

PuigM

SerranoJA

2004 Nocardia otitidiscaviarum (GAM-5) induces parkinsonian-like alterations in mouse. Braz J Med Biol Res 37 539 548

167. CassarinoDS

QuezadoMM

GhatakNR

DurayPH

2003 Lyme-associated parkinsonism: a neuropathologic case study and review of the literature. Arch Pathol Lab Med 127 1204 1206

168. KoutsilieriE

SopperS

SchellerC

ter MeulenV

RiedererP

2002 Parkinsonism in HIV dementia. J Neural Transm 109 767 775

169. WellerC

OxladeN

DobbsSM

DobbsRJ

CharlettA

2005 Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism. FEMS Immunol Med Microbiol 44 129 135

170. DobbsRJ

DobbsSM

WellerC

CharlettA

BjarnasonIT

2008 Helicobacter hypothesis for idiopathic parkinsonism: before and beyond. Helicobacter 13 309 322

171. TakahashiM

YamadaT

1999 Viral etiology for Parkinson's disease–a possible role of influenza A virus infection. Jpn J Infect Dis 52 89 98

172. StoesslAJ

1999 Etiology of Parkinson's disease. Can J Neurol Sci 26 Suppl 2 S5 12

173. BrennerS

1974 The genetics of Caenorhabditis elegans. Genetics 77 71 94

174. MilatovicD

AschnerM

2009 Measurement of Isoprostanes as Markers of Oxidative Stress in Neuronal Tissue. Current Protocols in Toxicology unit 12.14 1 12

Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


2010 Číslo 8
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Získaná hemofilie - Povědomí o nemoci a její diagnostika
nový kurz

Eozinofilní granulomatóza s polyangiitidou
Autori: doc. MUDr. Martina Doubková, Ph.D.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#