Infections after kidney transplantation

Česká verzia

Authors: Iva Svobodová ¹; Eva Honsová ²
Authors place of work: I. patologicko-anatomický ústav LF MU a FN u sv. Anny v Brně ¹; Pracoviště klinické a transplantační patologie, Transplantcentrum IKEM, Praha ²
Published in the journal: Čes.-slov. Patol., 51, 2015, No. 3, p. 120-122
Category: Přehledový článek

Summary

Immunosuppressed kidney transplant recipients are at risk for a variety of infectious complications and more than half of them suffered from this complication in the early post-transplant period. Despite the fact that the long term risk of serious infectious complications in the early postoperative period decreased, remain the infection the most frequent cause of morbidity in the first 6 months after transplant. It is important to realize that the clinical manifestations of infection in the compromised host are variable and often atypical.

In the later period, infections that affect the kidney graft become clinically important, and some of them occur only in immunosuppressed patients. Here we will discuss polyomavirus nephropathy which represents the most important and most frequent viral disease of renal allografts.

Keywords:
polyomavirus nephropathy –⁠ kidney transplantation –⁠ infectious complications

Zdroje

1. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3 : 611-623.

2. Jiang M, Abend J, Johnson S et al. The role of polyomaviruses in human disease. Virology 2009; 20 : 266-273.

3. Ducharme-Smith A, Katz BZ, Bobrowski AE et al. Prevalence of BK polyomavirus infection and association with renal dysfunction in pediatric heart transplant recipients. J Heart Lung Transplant 2015; 34(2): 222-226.

4. Aksenova M, Tsetlina V, Gutovskaya E et al. BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation. Pediatr Transplant 2015; 19(1): E29-32.

5. Mackenzie EF, Poulding JM, Harrison PR et al. Human polyoma virus (HPV) -⁠ a significant pathogen in renal transplantation. Proc Eur Dial Transplant Assoc 1978; 15 : 352-360.

6. Bechert Ch, Schnadig V, Payne D, Dong J. Monitoring of BK viral load in renal allograft recipients by Real –⁠ time PCR assays. Am J Clin Pathol 2010; 133 : 242-250.

7. Singh HK, Reisner H, Derebail VK et al. Polyomavirus nephropathy: quantitative urinary polyomavirus-haufen testing accurately predicts the degree of intrarenal viral disease. Transplantation 2015; 99(3): 609-615.

8. Drachenberg C, Hirsch HH, Ramos E et al. Polyomavirus disease in renal transplantation: Review of Pathological findings and diagnostic methods. Hum Pathol 2005; 36 : 1245-1255.

9. Petrogiannis-Haliotis T, Sakoulas G, Kirby J, et al. BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med 2001; 345 : 1250-1255.