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Non-Human Primates Harbor Diverse Mammalian and Avian Astroviruses Including Those Associated with Human Infections


With the advances in next generation sequencing and pathogen discovery, astrovirus (AstV), leading cause of diarrhea in children, the elderly and immunocompromised people, detection in diverse animal hosts has increased. Yet, to date there has been no detection of AstVs associated with human infections in animals suggesting these strains are specific to humans. In these studies we demonstrate that non-human primates (NHP) harbor a wide variety of AstVs including those previously only detected in people. Further, we identified an NHP with an AstV that is a recombination between human and animal genotypes. Our studies provide important new evidence that human astroviruses can be detected in animals directly challenging the paradigm that AstV infection is species-specific.


Vyšlo v časopise: Non-Human Primates Harbor Diverse Mammalian and Avian Astroviruses Including Those Associated with Human Infections. PLoS Pathog 11(11): e32767. doi:10.1371/journal.ppat.1005225
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005225

Souhrn

With the advances in next generation sequencing and pathogen discovery, astrovirus (AstV), leading cause of diarrhea in children, the elderly and immunocompromised people, detection in diverse animal hosts has increased. Yet, to date there has been no detection of AstVs associated with human infections in animals suggesting these strains are specific to humans. In these studies we demonstrate that non-human primates (NHP) harbor a wide variety of AstVs including those previously only detected in people. Further, we identified an NHP with an AstV that is a recombination between human and animal genotypes. Our studies provide important new evidence that human astroviruses can be detected in animals directly challenging the paradigm that AstV infection is species-specific.


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Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

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PLOS Pathogens


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