Five Questions about Mycoviruses

1. Ghabrial SA, Castón JR, Jiang D, Nibert ML, Suzuki N (2015) 50-plus years of fungal viruses. Virology 479: 356–368. doi: 10.1016/j.virol.2015.02.034 25771805

2. King AM, Adams MJ, Lefkowitz EJ (2011) Virus taxonomy: classification and nomenclature of viruses: Ninth Report of the International Committee on Taxonomy of Viruses: Elsevier.

3. Jiang D, Fu Y, Ghabrial SA (2013) Mycoviruses: Chapter eight—Viruses of the plant pathogenic fungus Sclerotinia sclerotiorum. Adv Virus Res 86: 215–248. doi: 10.1016/B978-0-12-394315-6.00008-8 23498908

4. Pearson MN, Beever RE, Boine B, Arthur K (2009) Mycoviruses of filamentous fungi and their relevance to plant pathology. Mol Plant Pathol 10: 115–128. doi: 10.1111/j.1364-3703.2008.00503.x 19161358

5. Herrero N, Dueñas E, Quesada-Moraga E, Zabalgogeazcoa I (2012) Prevalence and diversity of viruses in the entomopathogenic fungus Beauveria bassiana. Appl Environ Microbiol 78: 8523–8530. doi: 10.1128/AEM.01954-12 23001673

6. Roossinck MJ (2014) Metagenomics of plant and fungal viruses reveals an abundance of persistent lifestyles. Front Microbiol 5: 767–769. doi: 10.3389/fmicb.2014.00767 25628611

7. Nibert ML, Ghabrial SA, Maiss E, Lesker T, Vainio EJ, et al. (2014) Taxonomic reorganization of family Partitiviridae and other recent progress in partitivirus research. Virus Res 188: 128–141. doi: 10.1016/j.virusres.2014.04.007 24768846

8. Kwon S-J, Lim W-S, Park S-H, Park M-R (2007) Molecular characterization of a dsRNA mycovirus, Fusarium graminearum virus-DK21, which is phylogenetically related to hypoviruses but has a genome organization and gene expression strategy resembling those of plant potex-like viruses. Mol Cell 23: 304–315.

9. Nuss DL (2005) Hypovirulence: mycoviruses at the fungal–plant interface. Nat Rev Microbiol 3: 632–642. 16064055

10. Xie J, Jiang D (2014) New Insights into mycoviruses and exploration for the biological control of crop fungal diseases. Annu Rev Phytopathol 52: 45–68. doi: 10.1146/annurev-phyto-102313-050222 25001452

11. Craven M, Pawlyk D, Choi GH, Nuss DL (1993) Papain-like protease p29 as a symptom determinant encoded by a hypovirulence-associated virus of the chestnut blight fungus. J Virol 67: 6513–6521. 8411354

12. Chu Y-M, Jeon J-J, Yea S-J, Kim Y-H, Yun S-H, et al. (2002) Double-stranded RNA mycovirus from Fusarium graminearum. Appl Environ Microbiol 68: 2529–2534. 11976130

13. Lee K-M, Yu J, Son M, Lee Y-W, Kim K-H (2011) Transmission of Fusarium boothii mycovirus via protoplast fusion causes hypovirulence in other phytopathogenic fungi. PLoS One 6: e21629. doi: 10.1371/journal.pone.0021629 21738738

14. Marzano S-YL, Hobbs HA, Nelson BD, Hartman GL, Eastburn DM, et al. (2015) Transfection of Sclerotinia sclerotiorum with in vitro transcripts of a naturally occurring interspecific recombinant of Sclerotinia sclerotiorum hypovirus 2 significantly reduces virulence of the fungus. J Virol 89: 5060–5071. doi: 10.1128/JVI.03199-14 25694604

15. Chen B, Choi GH, Nuss DL (1994) Attenuation of fungal virulence by synthetic infectious hypovirus transcripts. Science 264: 1762–1764. 8209256

16. Choi GH, Nuss DL (1992) Hypovirulence of chestnut blight fungus conferred by an infectious viral cDNA. Science 257: 800–803. 1496400

17. Choi GH, Dawe AL, Churbanov A, Smith ML, Milgroom MG, et al. (2012) Molecular characterization of vegetative incompatibility genes that restrict hypovirus transmission in the chestnut blight fungus Cryphonectria parasitica. Genetics 190: 113–127. doi: 10.1534/genetics.111.133983 22021387

18. Wickner RB, Fujimura T, Esteban R (2013) Viruses and prion of Saccharomyces cerevisiae. Adv Virus Res 86: 1–36. doi: 10.1016/B978-0-12-394315-6.00001-5 23498901

19. Lee K-M, Cho WK, Yu J, Son M, Choi H, et al. (2014) A Comparison of transcriptional patterns and mycological phenotypes following infection of Fusarium graminearum by four mycoviruses. PloS One 9: e100989. doi: 10.1371/journal.pone.0100989 24964178

20. Allen TD, Dawe AL, Nuss DL (2003) Use of cDNA microarrays to monitor transcriptional responses of the chestnut blight fungus Cryphonectria parasitica to infection by virulence-attenuating hypoviruses. Eukaryot Cell 2: 1253–1265. 14665460

21. Li H, Fu Y, Jiang D, Li G, Ghabrial SA, et al. (2008) Down-regulation of Sclerotinia sclerotiorum gene expression in response to infection with Sclerotinia sclerotiorum debilitation-associated RNA virus. Virus Res 135: 95–106. doi: 10.1016/j.virusres.2008.02.011 18384901

22. Cho WK, Yu J, Lee K- M, Son M, Min K, et al. (2012) Genome-wide expression profiling shows transcriptional reprogramming in Fusarium graminearum by Fusarium graminearum virus 1-DK21 infection. BMC Genomics 13: 173–188. doi: 10.1186/1471-2164-13-173 22559730

23. Sun Q, Choi GH, Nuss DL (2009) Hypovirus-responsive transcription factor gene pro1 of the chestnut blight fungus Cryphonectria parasitica is required for female fertility, asexual spore development, and stable maintenance of hypovirus infection. Eukaryot Cell 8: 262–270. doi: 10.1128/EC.00338-08 19114501

24. Son M, Lee K-M, Yu J, Kang M, Park JM, et al. (2013) The hex1 gene of Fusarium graminearum is required for fungal asexual reproduction and pathogenesis and for efficient viral RNA accumulation of Fusarium graminearum virus 1. J Virol 87: 10356–10367. doi: 10.1128/JVI.01026-13 23864619

25. Chang S-S, Zhang Z, Liu Y (2012) RNA interference pathways in fungi: mechanisms and functions. Annu Rev Microbiol 66: 305–323. doi: 10.1146/annurev-micro-092611-150138 22746336

26. Zhnag DX, Spiering Ml, Nuss DL (2014) Charaterizing the roles of Cryphonectria parasitica RNA-dependent RNA polymerase-like genes in antiviral defense, viral recombination and transposon transcript accumulation. PLoS One 9: e108653. doi: 10.1371/journal.pone.0108653 25268858

27. Yaegashi H, Yoshikawa N, Ito T, Kanematsu S (2013) A mycoreovirus suppresses RNA silencing in the white root rot fungus, Rosellinia necatrix. Virology 444: 409–416. doi: 10.1016/j.virol.2013.07.010 23896640

28. Roossinck MJ (2011) The good viruses: viral mutualistic symbioses. Nat Rev Microbiol 9: 99–108. doi: 10.1038/nrmicro2491 21200397

29. Márquez LM, Roossinck MJ (2012) Do persistent RNA viruses fit the trade-off hypothesis of virulence evolution? Curr Opin Virol 2: 556–560. doi: 10.1016/j.coviro.2012.06.010 22819020

30. Drinnenberg IA, Fink GR, Bartel DP (2011) Compatibility with killer explains the rise of RNAi-deficient fungi. Science 333: 1592. doi: 10.1126/science.1209575 21921191

31. Kast A, Voges R, Schroth M, Schaffrath R, Klassen, et al. (2015) Autoselection of cytoplasmic yeast virus like elements encoding toxin/antitoxin system involvoes a nuclear barrier for immunity gene expression. PLoS Genet 11: e1005005. doi: 10.1371/journal.pgen.1005005 25973601

32. Márquez LM, Redman RS, Rodriguez RJ, Roossinck MJ (2007) A virus in a fungus in a plant: three-way symbiosis required for thermal tolerance. Science 315: 513–515. 17255511

33. Gao K, Xiong Q, Xu J, Wang K, Wang K (2013) CpBir1 is required for conidiation, virulence and anti-apoptotic effects and influences hypovirus transmission in Cryphonectria parasitica. Fungal Genet Biol 51: 60–71. doi: 10.1016/j.fgb.2012.09.011 23084963

34. Park S-M, Choi E-S, Kim M-J, Cha B-J, Yang M-s, et al (2004) Charaterization of HOG1 homologue, CpMK1, from Cryphonectria parasitica and evidence for hypovirus mediated perturbation of its phosphorylation in response to hypertonic stress. Mol Microbiol 51: 1267–1277. 14982623

35. Faruk MI, Eusebio-Cope A, Suzuki N (2008) A host factor involved in hypovirus symptom expression in the chestnut blight fungus, Cryphonectria parasitica. J Virol 82: 740–754. 17977965

36. Soldevila AI, Havens WM, Ghabrial SA (2000) A cellular protein with ana RNA-binding activity co-purifies with viral dsRNA from mucovirus-infect Helminthosporium victoriae. Virol 272: 183–190.

37. Zue W, Wei W, Fu Y, Cheng J, Xie J, et al (2013) A secretory protein of necrotrophic fungus Sclerotinia sclerotiorum that suppresses host resistance. PLoS One 8: e53901. doi: 10.1371/journal.pone.0053901 23342034

38. Yu J, Lee K-M, Son M, Kim K-H (2014) Effects of the deletion and over-expression of Fusarium graminearum gene FgHal2 on host response to mycovirus Fusarium graminearum virus 1. Mol Plant Pathol 16: 641–652.