50 Years of Disease in Humans: The Dramatic Emergence of a Cluster of Novel Fungal Pathogens

1. Emmons CW, Jellison WL. Emmonsia crescens sp. n. and adiaspiromycosis (haplomycosis) in mammals. Ann N Y Acad Sci. 1960;89 : 91–101. 13696711

2. Sigler L. Adiaspiromycosis and other infections caused by Emmonsia species. In: Hay RJ, Merz WG, editors. Topley and Wilson’s Microbiology and Microbial Infections. 10th ed. London, U.K.: Arnold Hodder; 2005. pp. 809–824.

3. Anstead GM, Sutton DA, Graybill JR. Adiaspiromycosis causing respiratory failure and a review of human infections due to Emmonsia and Chrysosporium spp. J Clin Microbiol. 2012;50 : 1346–1354. doi: 10.1128/JCM.00226-11 22259200

4. England DM, Hochholzer L. Adiaspiromycosis: an unusual fungal infection of the lung. Report of 11 cases. Am J Surg Pathol. 1993;17 : 876–86. 8352373

5. Borman AM, Simpson VR, Palmer MD, Linton CJ, Johnson EM. Adiaspiromycosis due to Emmonsia crescens is widespread in native British mammals. Mycopathologia. 2009;168 : 153–63. doi: 10.1007/s11046-009-9216-6 19533414

6. Sigler L, Peterson SW. Molecular genetic analysis supports recognition of new species among Emmonsia and Blastomyces isolates. International journal of antimicrobial agents. 2009. p. S593.

7. Doby-Dubois M, Chevrel ML, Doby JM, Louvet M. [1st human case of adiaspiromycosis, caused by Emmonsia crescens, Emmons and Jellison, 1960]. Bull Soc Pathol Exot Filiales. 1964;57 : 240–4. 14184774

8. Echavarria E, Cano EL, Restrepo A. Disseminated adiaspiromycosis in a patient with AIDS. J Med Vet Mycol. 1993;31 : 91–97. 8483061

9. Turner D, Burke M, Bashe E, Blinder S, Yust I. Pulmonary adiaspiromycosis in a patient with acquired immunodeficiency syndrome. Eur J Clin Microbiol Infect Dis. 1999;18 : 893–5. 10691202

10. Mendes MO, Moraes MAP, Renoiner EIM, Dantas MHP, Lanzieri TM, Fonseca CF, et al. Acute conjunctivitis with episcleritis and anterior uveitis linked to adiaspiromycosis and freshwater sponges, Amazon region, Brazil, 2005. Emerg Infect Dis. 2009;15 : 633–9. doi: 10.3201/eid1504.081281 19331759

11. Kenyon C, Bonorchis K, Corcoran C, Meintjes G, Locketz M, Lehloenya R, et al. A dimorphic fungus causing disseminated infection in South Africa. N Engl J Med. 2013;369 : 1416–1424. doi: 10.1056/NEJMoa1215460 24106934

12. Sekhon AS, Jackson FL, Jacobs HJ. Blastomycosis: report of the first case from Alberta Canada. Mycopathologia. 1982;79 : 65–69. 6813742

13. Peterson SW, Sigler L. Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and other systemic fungal pathogens. J Clin Microbiol. 1998;36 : 2918–25. 9738044

14. Sanche S, Wong A, Sigler L, Angel S, Peterson S. Invasive infection caused by a novel Emmonsia species in a renal transplant patient. Focus on Fungal Infections. Miami; 2005. p. Abstr 87.

15. Kemna ME, Weinberger M, Sigler L, Zeltser R, Polachek I, Salkin. IF. A primary oral blastomycosis-like infection in Israel, abstr. F-75. 94th General Meeting of the American Society for Microbiology. Washington, DC; 1994. p. 601.

16. Heys I, Taljaard J, Orth H. An emmonsia species causing disseminated infection in South Africa. N Engl J Med. 2014;370 : 283–284.

17. Schwartz IS, Govender NP, Corcoran C, Dlamini S, Prozesky H, Burton R, et al. Clinical characteristics, diagnosis, management and outcomes of disseminated emmonsiosis: a retrospective case series. Clin Infect Dis. 2015.; 61(6):1004–12. doi: 10.1093/cid/civ439 26060283

18. Stielow JB, Moreno L, Kenyon C, Botha A, Lerm B, Govender N, et al. From ITS to genomes: two novel Emmonsia species with fully annotated genomes. Genomics of Neglected Pathogens—CBS Symposium Week. Utrecht: CBS-KNAW Fungal Biodiversity Centre; 2015. http://www.blackyeast.org/GenomicsNeglectedPathogens/files/Benjamin_Stielow.pdf

19. Gori S, Drouhet E. Cutaneous disseminated mycosis in a patient with AIDS due to a new dimorphic fungus. J Mycol Med. 1998;8 : 57–63.

20. Drouhet E, Gueho E, Gori S, Huerre M, Provost F, Borgers M, et al. Mycological, ultrastructural and experimental aspects of a new dimorphic fungus Emmonsia pasteuriana sp. nov. isolated from a cutaneous disseminated mycosis in AIDS. J Mycol Med. 1998;8 : 64–77.

21. Pelegrín I, Ayats J, Xiol X, Cuenca-Estrella M, Jucglà A, Boluda S, et al. Disseminated adiaspiromycosis: case report of a liver transplant patient with human immunodeficiency infection, and literature review. Transpl Infect Dis. 2011;13 : 507–514. doi: 10.1111/j.1399-3062.2011.00611.x 21323828

22. Pelegrín I, Alastruey-Izquierdo A, Ayats J, Cuenca-Estrella M, Cabellos C. A second look at Emmonsia infection can make the difference. Transpl Infect Dis. 2014;0 : 1–2.

23. Feng P, Yin S, Zhu G, Li M, Wu B, Xie Y, et al. Disseminated infection caused by Emmonsia pasteuriana in a renal transplant recipient. J Dermatol. Epub 2015 Jun 24.

24. Tang XH, Zhou H, Zhang XQ, Han J De, Gao Q. Cutaneous Disseminated Emmonsiosis Due to Emmonsia pasteuriana in a Patient With Cytomegalovirus Enteritis. JAMA dermatology. 2015;151(9):1026–1028

25. Lochan H, Naicker P, Maphanga T, Ryan A, Pillay K, Govender NP, et al. A case of emmonsiosis in an HIV-infected child. S Afr J HIV Med. 2015;16 : 2–5.

26. Wellinghausen N, Kern W V, Haase G, Rozdzinski E, Kern P, Marre R, et al. Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp. Int J Med Microbiol. 2003;293 : 441–5. 14760976

27. Dukik K, Feng P, Freeke J, Nasrabadi, Azadeh Jamalian; Stielow B, Gerrits van den Ende B, de Hoog S. Redefining the genus Emmonsia: emergence of new dimorphic human pathogens. Genomics of Neglected Pathogens—CBS Symposium Week. Utrecht: CBS-KNAW Fungal Biodiversity Centre; 2015. http://www.blackyeast.org/GenomicsNeglectedPathogens/files/Karolina_Dukik.pdf

28. Drouhet E, Huerre M. Yeast tissue phase of Emmonsia pasteuriana inoculated in golden hamster by intratesticular way. Mycoses. 1999;42 Suppl 2 : 11–8. 10865897

29. Moraes MA, de Almeida MC, Raick AN. [A fatal case of human pulmonary adiaspiromycosis]. Rev Inst Med Trop Sao Paulo. 1989;31 : 188–94. 2694306

30. Peres LC, Figueiredo F, Peinado M, Soares FA. Fulminant disseminated pulmonary adiaspiromycosis in humans. Am J Trop Med Hyg. 1992;46 : 146–50. 1539748

31. Barbas Filho J V, Amato MB, Deheinzelin D, Saldiva PH, de Carvalho CR. Respiratory failure caused by adiaspiromycosis. Chest. 1990;97 : 1171–5. 2331914

32. Watts JC. Adiaspiromycosis. An uncommon disease caused by an unusual pathogen. CHEST J. American College of Chest Physicians; 1990;97 : 1030.

33. Carmichael JW. Chrysosporium and some other aleuriosporic hyphomycetes. Can J Bot. 1962;40 : 1137–1174.

34. Sigler L. Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis). J Med Vet Mycol. 1996;34 : 303–14. 8912163

35. Guého E, Leclerc MC, de Hoog GS, Dupont B. Molecular taxonomy and epidemiology of Blastomyces and Histoplasma species. Mycoses. 1997;40 : 69–81. 9375491

36. Leclerc MC, Philippe H, Guého E. Phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal RNA sequence comparisons. J Med Vet Mycol. 1994;32 : 331–41. 7844699