Human Genetic Susceptibility to Invasive Aspergillosis

1. KontoyiannisDP, MarrKA, ParkBJ, AlexanderBD, AnaissieEJ, et al. (2010) Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 50 : 1091–1100.

2. PaganoL, CairaM, CandoniA, OffidaniM, MartinoB, et al. (2010) Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study. Haematologica 95 : 644–650.

3. LatgeJP (2010) Tasting the fungal cell wall. Cell Microbiol 12 : 863–872.

4. RomaniL (2011) Immunity to fungal infections. Nat Rev Immunol 11 : 275–288.

5. SorciG, GiovanniniG, RiuzziF, BonifaziP, ZelanteT, et al. (2011) The danger signal S100B integrates pathogen -⁠ and danger-sensing pathways to restrain inflammation. PLoS Pathog 7: e1001315 doi:10.1371/journal.ppat.1001315

6. GrahlN, PuttikamonkulS, MacdonaldJM, GamcsikMP, NgoLY, et al. (2011) In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog 7: e1002145 doi:10.1371/journal.ppat.1002145

7. VinhDC (2011) Insights into human antifungal immunity from primary immunodeficiencies. Lancet Infect Dis 11 : 780–792.

8. CunhaC, AversaF, BistoniG, CasagrandeA, RodriguesF, et al. (2011) Immunogenetic profiling to predict risk of invasive fungal diseases: where are we now? Immunol Invest 40 : 723–734.

9. CunhaC, RomaniL, CarvalhoA (2010) Cracking the Toll-like receptor code in fungal infections. Expert Rev Anti Infect Ther 8 : 1121–1137.

10. van der VeldenWJFM, BlijlevensNMA, DonnellyJP (2011) Genetic variants and the risk for invasive mould disease in immunocompromised hematology patients. Curr Opin Infect Dis 24 : 554–563.

11. BochudPY, ChienJW, MarrKA, LeisenringWM, UptonA, et al. (2008) Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 359 : 1766–1777.

12. CarvalhoA, PasqualottoAC, PitzurraL, RomaniL, DenningDW, et al. (2008) Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infect Dis 197 : 618–621.

13. CarvalhoA, CunhaC, CarottiA, AloisiT, GuarreraO, et al. (2009) Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation. Exp Hematol 37 : 1022–1029.

14. CarvalhoA, De LucaA, BozzaS, CunhaC, D'AngeloC, et al. (2012) TLR3 essentially promotes protective class I-restricted memory CD8(+) T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Blood 119 : 967–977.

15. ChaiLY, de BoerMG, van der VeldenWJ, PlantingaTS, van SprielAB, et al. (2011) The Y238X stop codon polymorphism in the human beta-glucan receptor dectin-1 and susceptibility to invasive aspergillosis. J Infect Dis 203 : 736–743.

16. CunhaC, Di IanniM, BozzaS, GiovanniniG, ZagarellaS, et al. (2010) Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient -⁠ and donor-dependent mechanisms of antifungal immunity. Blood 116 : 5394–5402.

17. SainzJ, LupiáñezCB, Segura-CatenaJ, VazquezL, RíosR, et al. (2012) Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection. PLoS ONE 7: e32273 doi:10.1371/journal.pone.0032273

18. CunhaC, GiovanniniG, PieriniA, BellAS, SorciG, et al. (2011) Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. PLoS ONE 6: e27962 doi:10.1371/journal.pone.0027962

19. MezgerM, SteffensM, BeyerM, MangerC, EberleJ, et al. (2008) Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells. Blood 111 : 534–536.

20. DurrantC, TayemH, YalcinB, CleakJ, GoodstadtL, et al. (2011) Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection. Genome Res 21 : 1239–1248.

21. ZaasAK, LiaoG, ChienJW, WeinbergC, ShoreD, et al. (2008) Plasminogen alleles influence susceptibility to invasive aspergillosis. PLoS Genet 4: e1000101 doi:10.1371/journal.pgen.1000101

22. GranellM, Urbano-IspizuaA, SuarezB, RoviraM, Fernandez-AvilesF, et al. (2006) Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation. Exp Hematol 34 : 1435–1441.

23. LambourneJ, AgranoffD, HerbrechtR, TrokePF, BuchbinderA, et al. (2009) Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients. Clin Infect Dis 49 : 1486–1491.

24. CharlsonES, DiamondJM, BittingerK, FitzgeraldAS, YadavA, et al. (2012) Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota after lung transplant. Am J Respir Crit Care Med 186 : 536–545.

25. SainzJ, PerezE, Gomez-LoperaS, JuradoM (2008) IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level. J Clin Immunol 28 : 473–485.

26. SeoKW, KimDH, SohnSK, LeeNY, ChangHH, et al. (2005) Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant 36 : 1089–1095.

27. SainzJ, HassanL, PerezE, RomeroA, MoratallaA, et al. (2007) Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis. Immunol Lett 109 : 76–82.

28. KeshS, MensahNY, PeterlongoP, JaffeD, HsuK, et al. (2005) TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci 1062 : 95–103.

29. SainzJ, Salas-AlvaradoI, Lopez-FernandezE, OlmedoC, CominoA, et al. (2010) TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis. Int J Immunopathol Pharmacol 23 : 423–436.

30. SainzJ, PerezE, HassanL, MoratallaA, RomeroA, et al. (2007) Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis. Hum Immunol 68 : 41–50.