Host Immune Response to Intestinal Amebiasis

1. BarteltLA, LimaAAM, KosekM, Peñataro YoriP, LeeG, et al. (2013) “Barriers” to child development and human potential: the case for including the “neglected enteric protozoa” (NEP) and other enteropathy-associated pathogens in the NTDs. PLoS Negl Trop Dis 7: e2125 doi:10.1371/journal.pntd.0002125

2. MondalD, MinakJ, AlamM, LiuY, DaiJ, et al. (2012) Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clin Infect Dis 54: 185–192.

3. ChadeeK, PetriWAJr, InnesDJ, RavdinJI (1987) Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica. J Clin Invest 80: 1245–1254.

4. LidellME, MoncadaDM, ChadeeK, HanssonGC (2006) Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci U S A 103: 9298–9303.

5. BansalD, AveP, KerneisS, FrileuxP, BochéO, et al. (2009) An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis. PLoS Negl Trop Dis 3: e551 doi:10.1371/journal.pntd.0000551

6. YuY, ChadeeK (1997) Entamoeba histolytica stimulates interleukin 8 from human colonic epithelial cells without parasite-enterocyte contact. Gastroenterology 112: 1536–1547.

7. DenisM, ChadeeK (1989) Human neutrophils activated by interferon-gamma and tumour necrosis factor-alpha kill Entamoeba histolytica trophozoites in vitro. J Leukoc Biol 46: 270–274.

8. GuerrantRL, BrushJ, RavdinJI, SullivanJA, MandellGL (1981) Interaction between Entamoeba histolytica and human polymorphonuclear neutrophils. J Infect Dis 143: 83–93.

9. AsgharpourA, GilchristC, BabaD, HamanoS, HouptE (2005) Resistance to intestinal Entamoeba histolytica infection is conferred by innate immunity and Gr-1+ cells. Infect Immun 73: 4522–4529.

10. LinJY, SeguinR, KellerK, ChadeeK (1994) Tumor necrosis factor alpha augments nitric oxide-dependent macrophage cytotoxicity against Entamoeba histolytica by enhanced expression of the nitric oxide synthase gene. Infect Immun 62: 1534–1541.

11. GhadirianE, DenisM (1992) Entamoeba histolytica extract and interferon-gamma activation of macrophage-mediated amoebicidal function. Immunobiology 185: 1–10.

12. KammanadimintiSJ, MannBJ, DutilL, ChadeeK (2004) Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolytica. FASEB J 18: 155–157.

13. Maldonado-BernalC, KirschningCJ, RosensteinY, RochaLM, Rios-SarabiaN, et al. (2005) The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4. Parasite Immunol 27: 127–137.

14. IvoryCP, PrystajeckyM, JobinC, ChadeeK (2008) Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA. Infect Immun 76: 289–297.

15. SeydelKB, SmithSJ, StanleySLJr (2000) Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease. Infect Immun 68: 400–402.

16. HouptE, BarrosoL, LockhartL, WrightR, CramerC, et al. (2004) Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine 22: 611–617.

17. Abd AllaMD, WolfR, WhiteGL, KosankeSD, CaryD, et al. (2012) Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.). Vaccine 30: 3068–3075.

18. HaqueR, AliIM, SackRB, FarrBM, RamakrishnanG, et al. (2001) Amebiasis and mucosal IgA antibody against the Entamoeba histolytica adherence lectin in Bangladeshi children. J Infect Dis 183: 1787–1793.

19. HaqueR, MondalD, ShuJ, RoyS, KabirM, et al. (2007) Correlation of interferon-gamma production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis. Am J Trop Med Hyg 76: 340–344.

20. GuoX, BarrosoL, BeckerSM, LyerlyDM, VedvickTS, et al. (2009) Protection against intestinal amebiasis by a recombinant vaccine is transferable by T cells and mediated by gamma interferon. Infect Immun 77: 3909–3918.

21. GuoX, BarrosoL, LyerlyDM, PetriWAJr, HouptER (2011) CD4+ and CD8+ T cell- and IL-17-mediated protection against Entamoeba histolytica induced by a recombinant vaccine. Vaccine 29: 772–777.

22. DavisPH, ZhangX, GuoJ, TownsendRR, StanleySLJr (2006) Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. Mol Microbiol 61: 1523–1532.

23. ElnekaveK, Siman-TovR, AnkriS (2003) Consumption of L-arginine mediated by Entamoeba histolytica L-arginase (EhArg) inhibits amoebicidal activity and nitric oxide production by activated macrophages. Parasite Immunol 25: 597–608.

24. DeyI, KellerK, BelleyA, ChadeeK (2003) Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica. Proc Natl Acad Sci U S A 100: 13561–13566.

25. WangW, ChadeeK (1995) Entamoeba histolytica suppresses gamma interferon-induced macrophage class II major histocompatibility complex Ia molecule and I-A beta mRNA expression by a prostaglandin E2-dependent mechanism. Infect Immun 63: 1089–1094.

26. RicoG, LeandroE, RojasS, GimenezJA, KretschmerRR (2003) The monocyte locomotion inhibitory factor produced by Entamoeba histolytica inhibits induced nitric oxide production in human leukocytes. Parasitol Res 90: 264–267.

27. BragaLL, NinomiyaH, McCoyJJ, EackerS, WiedmerT, et al. (1992) Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica. J Clin Invest 90: 1131–1137.

28. ReedSL, EmberJA, HerdmanDS, DiScipioRG, HugliTE, et al. (1995) The extracellular neutral cysteine proteinase of Entamoeba histolytica degrades anaphylatoxins C3a and C5a. J Immunol 155: 266–274.

29. PetersonKM, ShuJ, DuggalP, HaqueR, MondalD, et al. (2010) Association between TNF-alpha and Entamoeba histolytica diarrhea. Am J Trop Med Hyg 82: 620–625.

30. ZhangZ, MahajanS, ZhangX, StanleySLJr (2003) Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease. Infect Immun 71: 5355–5359.

31. BraatH, RottiersP, HommesDW, HuyghebaertN, RemautE, et al. (2006) A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 4: 754–759.

32. HamanoS, AsgharpourA, StroupSE, WynnTA, LeiterEH, et al. (2006) Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol 177: 1208–1213.

33. HaqueR, DuggalP, AliIM, HossainMB, MondalD, et al. (2002) Innate and acquired resistance to amebiasis in bangladeshi children. J Infect Dis 186: 547–552.

34. GuoX, RobertsMR, BeckerSM, PoddB, ZhangY, et al. (2011) Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosal Immunol 4: 294–303.

35. DuggalP, GuoX, HaqueR, PetersonKM, RicklefsS, et al. (2011) A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest 121: 1191–1198.

36. MarieCS, VerkerkeHP, PaulSN, MackeyAJ, PetriWAJr (2012) Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism. Infect Immun 80: 1934–1943.

37. DuggalP, HaqueR, RoyS, MondalD, SackRB, et al. (2004) Influence of human leukocyte antigen class II alleles on susceptibility to Entamoeba histolytica infection in Bangladeshi children. J Infect Dis 189: 520–526.