Impact of Endofungal Bacteria on Infection Biology, Food Safety, and Drug Development

1. Partida-MartinezLPHertweckC 2005 Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 437 884 888

2. SatoZNodaTMatsudaIIwasakiSKobayashiH 1983 Studies on rhizoxin, a phytotoxin produced by Rhizopus chinensis causing rice seedling blight. Annu Phytopathol Soc Japan 49 128

3. SchmittIL.P.P-MWinklerRVoigtKEinaxE 2008 Evolution of host resistance in a toxin-producing bacterial-fungal alliance. ISME J 2 632 641

4. MoebiusNHertweckC 2009 Fungal phytotoxins as mediators of virulence. Current Opinion in Plant Biology 12 390 398

5. Partida-MartinezLPGrothISchmittIRichterWRothM 2007 Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus. Int J Syst Evol Microbiol 57 2583 2590

6. LacknerGPartida-MartinezLPHertweckC 2009 Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17 570 576

7. Partida-MartinezLPde LoossCFIshidaKIshidaMRothM 2007 Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Appl Environ Microbiol 73 793 797

8. WilsonTRabieCJFinchamJESteynPSSchipperMA 1984 Toxicity of rhizonin A, isolated from Rhizopus microsporus, in laboratory animals. Food Chem Toxicol 22 275 281

9. RohmBScherlachKMobiusNPartida-MartinezLPHertweckC 2010 Toxin production by bacterial endosymbionts of a Rhizopus microsporus strain used for tempe/sufu processing. Int J Food Microbiol 136 368 371

10. AntoniadouA 2009 Outbreaks of zygomycosis in hospitals. Clin Microbiol Infect 15 Suppl 5 55 59

11. IbrahimASGebremariamTLiuMFChamilosGKontoyiannisDP 2008 Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis. J Infect Dis 198 1083 1090

12. Partida-MartinezLPBandemerSRuchelRDannaouiEHertweckC 2008 Lack of evidence of endosymbiotic toxin-producing bacteria in clinical Rhizopus isolates. Mycoses 51 266 269

13. GeeJEGlassMBLacknerGHelselLODaneshvarM 2011 Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLoS ONE 6 e15731 doi:10.1371/journal.pone.0015731

14. TsuruoTOh-haraTLidaHTsukagoshiSSatoZ 1986 Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines. Cancer Res 46 381 385

15. McLeodHLMurrayLSWandersJSetanoiansAGrahamMA 1996 Multicentre phase II pharmacological evaluation of rhizoxin. Eortc early clinical studies (ECSG)/pharmacology and molecular mechanisms (PAMM) groups. Br J Cancer 74 1944 1948

16. HertweckC 2009 The biosynthetic logic of polyketide diversity. Angew Chem Int Ed Engl 48 4688 4716

17. Partida-MartinezLPHertweckC 2007 A gene cluster encoding rhizoxin biosynthesis in “Burkholderia rhizoxina”, the bacterial endosymbiont of the fungus Rhizopus microsporus. Chembiochem 8 41 45

18. KusebauchBBuschBScherlachKRothMHertweckC 2009 Functionally distinct modules operate two consecutive alpha,beta→beta,gamma double-bond shifts in the rhizoxin polyketide assembly line. Angew Chem Int Ed Engl 49 1460 1464

19. KusebauchBBuschBScherlachKRothMHertweckC 2009 Polyketide-chain branching by an enzymatic Michael addition. Angew Chem Int Ed Engl 48 5001 5004

20. ScherlachKPartida-MartinezLPDahseH-MHertweckC 2006 Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. J Am Chem Soc 128 11529 11536

21. Partida-MartinezLPMonajembashiSGreulichKOHertweckC 2007 Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism. Curr Biol 17 773 777

22. LacknerGMoebiusNHertweckC 2011 Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5 252 261

23. LacknerGMoebiusNScherlachKPartida-MartinezLPWinklerR 2009 Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75 2982 2986

24. LacknerGMoebiusNPartida-MartinezLPHertweckC 2011 Complete genome sequence of Burkholderia rhizoxinica, the endosymbiont of Rhizopus microsporus. J Bacteriol 193 783 784

25. LacknerGMoebiusNPartida-MartinezLPBolandSHertweckC 2011 Evolution of an endofungal lifestyle: deductions from the Burkholderia rhizoxinica genome. BMC Genomics In press

26. LeoneMRLacknerGSilipoALanzettaRMolinaroA 2010 An unusual galactofuranose lipopolysaccharide warrants intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49 7476 7480

27. CornelisGR 2006 The type III secretion injectisome. Nat Rev Microbiol 4 811 825